N-acetylcysteine: a novel approach to methaemoglobinaemia in normothermic liver machine perfusion.

Autor: Clarke, George, Mao, Jingwen, Fan, Yiyu, Hann, Angus, Gupta, Amita, Nutu, Anisa, Buckel, Erwin, Kayani, Kayani, Murphy, Nicholas, Bangash, Mansoor N., Casey, Anna L., Wootton, Isla, Lawson, Alexander J., Dasari, Bobby V. M., Perera, M. Thamara P. R., Mergental, Hynek, Afford, Simon C.

Publikováno v: Scientific Reports; 11/3/2023, Vol. 13 Issue 1, p1-8, 8p

A reproducible extended ex-vivo normothermic machine liver perfusion protocol utilising improved nutrition and targeted vascular flows.

Autor: Clarke G; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK. George.Clarke@uhb.nhs.uk.; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK. George.Clarke@uhb.nhs.uk.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK. George.Clarke@uhb.nhs.uk., Mao J; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Hann A; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Fan Y; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Gupta A; Ochre-Bio Ltd, Oxford, UK., Nutu A; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Buckel Schaffner E; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Kayani K; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK.; Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Murphy N; Intensive Care Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TH, UK., Bangash MN; Intensive Care Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TH, UK., Casey AL; Microbiology Department, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Wootton I; Clinical Biochemistry, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Lawson AJ; Clinical Biochemistry, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Dasari BVM; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK., Perera MTPR; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Mergental H; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2TH, UK.; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK., Afford SC; Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TH, UK.

Publikováno v: Communications medicine [Commun Med (Lond)] 2024 Oct 24; Vol. 4 (1), pp. 214. Date of Electronic Publication: 2024 Oct 24.