Very low HDL levels: clinical assessment and management

Autor: Isabella Bonilha de Oliveira, Beatriz Martinelli Luchiari, Wilson Nadruz, Andrei Sposito

Publikováno v: Archives of Endocrinology and Metabolism, Volume: 67, Issue: 1, Pages: 18-3, Published: 27 JAN 2023

In individuals with very low high-density lipoprotein (HDL-C) cholesterol, such as Tangier disease, LCAT deficiency, and familial hypoalphalipoproteinemia, there is an increased risk of premature atherosclerosis. However, analyzes based on comparison

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c62048bbb832079659a772dcdcad187
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972023000100003&lng=en&tlng=en

No benefit of HDL mimetic CER-001 on carotid atherosclerosis in patients with genetically determined very low HDL levels

Autor: Jean-Louis Dasseux, Yannick Kaiser, Erik S.G. Stroes, Daniel Gaudet, Aart J. Nederveen, Constance Keyserling, Robert A. Hegele, Jacques Genest, Kang H. Zheng, Raul D. Santos, Olivier S. Descamps, Jan Westerink, Casper C. van Olden, Paul N. Hopkins, Eran Leitersdorf, Hein J. Verberne

Publikováno v: Atherosclerosis, 311, 13-19. Elsevier Ireland Ltd

Background and aims Infusion of high-density lipoprotein (HDL) mimetics failed to induce regression of atherosclerosis in recent randomized clinical trials. However, patients in these previous trials had normal levels of HDL-cholesterol, which potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad0bb4c333e54dc4e6e32fb2d652dfc
https://doi.org/10.1016/j.atherosclerosis.2020.08.004

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

Autor: Raul D. Santos, Theo H. van Dijk, Erik S.G. Stroes, Loek P. Smits, Fleur M. van der Valk, John F. Paolini, Geesje M. Dallinga-van Thie, Aart J. Nederveen, Ruud S. Kootte, Albert K. Groen, Willem J. M. Mulder, G. Kees Hovingh, John J.P. Kastelein, Constance Keyserling, Ronald Barbaras, Jean-Louis Dasseux

Publikováno v: Journal of Lipid Research, 56(3), 703-712. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of lipid research, 56(3), 703-712. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 56, Iss 3, Pp 703-712 (2015)

Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with the orphan disease, familial hypoalphalipoproteinemia (FHA), are characterized by decreased tissue cholesterol removal and an increased atherogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69939042d1b1972246343ab07733bd59
https://doi.org/10.1194/jlr.m055665

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Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia

Autor: John J.P. Kastelein, Albert K. Groen, Remco Franssen, Karim El Harchaoui, Jan Albert Kuivenhoven, Frans Stellaard, Erik S.G. Stroes, Folkert Kuipers, Radjesh J. Bisoendial, G. Kees Hovingh

Publikováno v: ATHEROSCLEROSIS, 207(2), 614-616. ELSEVIER IRELAND LTD
Atherosclerosis, 207(2), 614-616. Elsevier Ireland Ltd

Background: Fecal bile acid and neutral sterol excretion are the obligate endpoints of the reverse cholesterol transport pathway (RCT). In studies in mice, no evidence was found for a relation between HDL-cholesterol (HDL-c) levels and fecal sterol e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938f6675863129a72af4260e185ca0e0
https://doi.org/10.1016/j.atherosclerosis.2009.06.022