Výsledky vyhledávání - "Familial Parkinsons-Disease"

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Akademický článek

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The unconventional G-protein cycle of LRRK2 and Roco proteins

Autor: Arjan Kortholt, Laura M Nederveen-Schippers, Susanne Terheyden

Publikováno v: Biochemical Society Transactions, 44(6), 1611-1616. PORTLAND PRESS LTD

Mutations in the human leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of hereditary Parkinson's disease (PD). LRRK2 belongs to the Roco family of proteins, which are characterized by the presence of a Ras of complex proteins domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb18ee5d2dde1e0dcf80db477eae777
https://research.rug.nl/en/publications/44b224c7-196d-402d-a0df-f42faaf3a727

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Complexation of NAC-Derived Peptide Ligands with the C-Terminus of alpha-Synuclein Accelerates Its Aggregation

Autor: JHA, NN, RANGANATHAN, S, KUMAR, R, MEHRA, S, PANIGRAHI, R, NAVALKAR, A, GHOSH, D, KUMAR, A, PADINHATEERI, R, MAJI, SK

Publikováno v: IndraStra Global.

Aggregation of alpha-synuclein (alpha-Syn) into neurotoxic oligomers and amyloid fibrils is suggested to be the pathogenic mechanism for Parkinson's disease (PD). Recent studies'have indicated that oligomeric species of alpha-Syn are more cytotoxic t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=issn23813652::0bf3f0b881388e49d9e0f7fe819ba5b9
http://dspace.library.iitb.ac.in/xmlui/handle/100/24967

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Raman optical activity of human α -synuclein in intrinsically disordered, micelle-bound α -helical, molten globule and oligomeric β -sheet state

Autor: Mensch, Carl, Konijnenberg, Albert, Van Elzen, Roos, Lambeir, Anne-Marie, Sobott, Frank, Johannessen, Christian

Publikováno v: Journal of Raman spectroscopy
JOURNAL OF RAMAN SPECTROSCOPY

Alpha-synuclein (α-syn) is a 140 residue protein that plays a central role in Parkinsons disease and other neurological disorders. The precise function and pathological properties of α-syn remain however poorly understood. While α-syn is considere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2f56ff53702a943ca65ac50015576a62

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alpha-synuclein aggregation and its modulation

Autor: Shruti Sahay, Samir K. Maji, Surabhi Mehra, Pradeep K. Singh, Dhiman Ghosh

Publikováno v: IndraStra Global.

Parkinson's disease (PD) is a neurological disorder marked by the presence of cytoplasmic inclusions, Lewy bodies (LBs) and Lewy neurites (LNs) as well as the degeneration of dopamine producing neurons in the substantia nigra region of the brain. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffbc76778ca7755c83dc0b2ae6f6e75
https://igi.indrastra.com/items/show/47468

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Akademický článek

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Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

Autor: Wojciech Bobela, Safa Mohanna, Patrick Aebischer, Marco Cantoni, Bernard L. Schneider, Graham Knott, Meret Nora Gaugler, Ralf Schneggenburger, Mustafa T. Ardah, Özgür Genç, Omar El-Agnaf, Jean-Charles Bensadoun

Publikováno v: Acta Neuropathologica; Vol 123
Acta neuropathologica

alpha-Synuclein (alpha-syn) is a presynaptic protein present at most nerve terminals, but its function remains largely unknown. The familial forms of Parkinson's disease associated with multiplications of the alpha-syn gene locus indicate that overab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3b233d8e158f184ea80b6c908879dd
https://doi.org/10.1007/s00401-012-0963-y

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Localization of MAP1-LC3 in Vulnerable Neurons and Lewy Bodies in Brains of Patients With Dementia With Lewy Bodies

Autor: Michiko Minegishi, Omi Katsuse, Heii Arai, Kiyoshi Sato, Keiji Wada, Darren J. Moore, Takashi Togo, Hiroshige Fujishiro, Kenji Kosaka, Yoshiko Furukawa, Eizo Iseki, Shinji Higashi, Koji Kasanuki, Hirotake Uchikado, Tomohiro Kabuta, Hiroaki Hino

Publikováno v: Journal of Neuropathology & Experimental Neurology. 70:264-280

There is emerging evidence implicating a role for the autophagy-lysosome pathway in the pathogenesis of Lewy body disease. We investigated potential neuropathologic and biochemical alterations of autophagy-lysosome pathway-related proteins in the bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a2dd0ecf0c9eea709ebebabc4fd71a
https://doi.org/10.1097/nen.0b013e318211c86a

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First Appraisal of Brain Pathology Owing to A30P Mutant Alpha-Synuclein

Autor: Silke Nuber, Rejko Krüger, K. Gierga, Abdelhaq Rami, Dennis W. Dickson, Elisabeth Petrasch-Parwez, Wilfried F. A. Den Dunnen, Wei P. Gai, Zbigniew K. Wszolek, Thomas Deller, Kay Seidel, Udo Rüb, Ludger Schöls, Antje Bornemann, Olaf Riess

Publikováno v: Annals of Neurology, 67(5), 684-689. Wiley

Familial Parkinson disease (PD) due to the A30P mutation in the SNCA gene encoding alpha-synuclein is clinically associated with PD symptoms. In this first pathoanatomical study of the brain of an A30P mutation carrier, we observed neuronal loss in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed25dfcf371931670455c149283ca374
https://hdl.handle.net/11370/67ef4a81-69ad-41e9-b0c3-b6f42a95e1f2

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