Structure–Activity Studies of 1H‑Imidazo[4,5‑c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators.

Autor: Fallot, Lucas B., Suresh, R. Rama, Fisher, Courtney L., Salmaso, Veronica, O'Connor, Robert D., Kaufman, Noy, Gao, Zhan-Guo, Auchampach, John A., Jacobson, Kenneth A.

Publikováno v: Journal of Medicinal Chemistry; 11/24/2022, Vol. 65 Issue 22, p15238-15262, 25p

Structure–Activity Studies of 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as A3Adenosine Receptor Positive Allosteric Modulators

Autor: Fallot, Lucas B., Suresh, R. Rama, Fisher, Courtney L., Salmaso, Veronica, O’Connor, Robert D., Kaufman, Noy, Gao, Zhan-Guo, Auchampach, John A., Jacobson, Kenneth A.

Publikováno v: Journal of Medicinal Chemistry; November 2022, Vol. 65 Issue: 22 p15238-15262, 25p

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Characterization of Dual-Acting A 3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gα i3 and Gα oA Isoprotein Activation.

Autor: Fisher CL; Department of Pharmacology & Toxicology and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States., Fallot LB; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States.; Department of Biochemistry & Molecular Biology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, United States.; Department of Chemistry & Life Science, United States Military Academy, 646 Swift Road, West Point, New York 10996, United States., Wan TC; Department of Pharmacology & Toxicology and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States., Keyes RF; Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States., Suresh RR; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States., Rothwell AC; Department of Pharmacology & Toxicology and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States., Gao ZG; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States., McCorvy JD; Department of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States., Smith BC; Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States., Jacobson KA; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States., Auchampach JA; Department of Pharmacology & Toxicology and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2022 Jul 15; Vol. 5 (8), pp. 625-641. Date of Electronic Publication: 2022 Jul 15 (Print Publication: 2022).