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Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.

Autor: Quevedo CE; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Cruz-Migoni A; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK., Bery N; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Miller A; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Tanaka T; Leeds Institute for Molecular Medicine, St James University Hospital, Leeds, LS9 7TF, UK.; Research & Development, Sanofi K.K., Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo, 163-1488, Japan., Petch D; Leeds Institute for Molecular Medicine, St James University Hospital, Leeds, LS9 7TF, UK., Bataille CJR; Chemistry Research Laboratory, 12 Mansfield Rd, Oxford, OX1 3TA, UK., Lee LYW; Domainex, Chesterford Research Park, Little Chesterford, Saffron Walden, CB10 1XL, UK., Fallon PS; Domainex, Chesterford Research Park, Little Chesterford, Saffron Walden, CB10 1XL, UK., Tulmin H; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK., Ehebauer MT; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.; Oxford Drug Discovery Institute, Nuffield Department of Medicine Research Building, University of Oxford, Old Road Campus, Oxford, OX3 7FZ, UK., Fernandez-Fuentes N; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK.; Institute of Biological, Environmental and Rural Sciences, University of Aberystwyth, Aberystwyth, SY23 3EB, UK., Russell AJ; Chemistry Research Laboratory, 12 Mansfield Rd, Oxford, OX1 3TA, UK., Carr SB; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Phillips SEV; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Rabbitts TH; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK. terence.rabbitts@imm.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2018 Aug 09; Vol. 9 (1), pp. 3169. Date of Electronic Publication: 2018 Aug 09.