Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Fallon Lin"'
Autor:
Levi A. Garraway, Angela N. Koehler, Lucienne Ronco, Raymond Pagliarini, Douglas S. Daniels, Fallon Lin, Elizabeth K. Culyba, Cheng Zhong, Timothy A. Lewis, Emily C. Hartman, Jean-Philippe Theurillat, Colin W. Garvie, Nicolas Stransky, Marius S. Pop
Members of the ETS transcription factor family have been implicated in several cancers, where they are often dysregulated by genomic derangement. ETS variant 1 (ETV1) is an ETS factor gene that undergoes chromosomal translocation in prostate cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b7be6ddfbcc316a35352a8de524552
https://doi.org/10.1158/1535-7163.c.6536437
https://doi.org/10.1158/1535-7163.c.6536437
Autor:
Levi A. Garraway, Angela N. Koehler, Lucienne Ronco, Raymond Pagliarini, Douglas S. Daniels, Fallon Lin, Elizabeth K. Culyba, Cheng Zhong, Timothy A. Lewis, Emily C. Hartman, Jean-Philippe Theurillat, Colin W. Garvie, Nicolas Stransky, Marius S. Pop
PDF file - 115K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8770a02253b111f21b0645a8ce4160
https://doi.org/10.1158/1535-7163.22500397.v1
https://doi.org/10.1158/1535-7163.22500397.v1
Autor:
Levi A. Garraway, Angela N. Koehler, Lucienne Ronco, Raymond Pagliarini, Douglas S. Daniels, Fallon Lin, Elizabeth K. Culyba, Cheng Zhong, Timothy A. Lewis, Emily C. Hartman, Jean-Philippe Theurillat, Colin W. Garvie, Nicolas Stransky, Marius S. Pop
PDF file - 1496K, Figure S1 - control expression and SMM hits representation; luciferase assay with MITF for BRD32048 and luciferase assay using BRD32048 analogs. Figure S2 - SPR data control graphs for TBX21 reference experiment. Figure S3 alternati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021b9c78d1d5e38f9008cb87d32d7958
https://doi.org/10.1158/1535-7163.22500400
https://doi.org/10.1158/1535-7163.22500400
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
PDF file - 348KB, Figure S1: Isogenic IDH1 mutation compromises metabolic reprogramming under hypoxia. Figure S2: Simulated and measured uncorrected MIDs. Figure S3: Compromised Reductive TCA Metabolism is specific to cells with mutant IDH1. Figure S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376c269450e5947866e21be024083aa0
https://doi.org/10.1158/0008-5472.22404444
https://doi.org/10.1158/0008-5472.22404444
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
PDF file - 93KB, Estimates Fluxes for HCT116 Parental and IDH1 R132H/+ 2H1 cells under Normoxia and Hypoxia (2 percent Oxygen).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b28b49cb8efffcec5890dedaa06d63
https://doi.org/10.1158/0008-5472.22404438
https://doi.org/10.1158/0008-5472.22404438
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
PDF file - 136KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c83526185c0fd14582306beb658d0d3
https://doi.org/10.1158/0008-5472.22404441.v1
https://doi.org/10.1158/0008-5472.22404441.v1
Autor:
Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian
Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed 13C metabolic flux analysis on a panel of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e49274eaaaa28fa6411ec05c17088e
https://doi.org/10.1158/0008-5472.c.6506604.v1
https://doi.org/10.1158/0008-5472.c.6506604.v1
Autor:
Zineb Mounir, Joshua M Korn, Thomas Westerling, Fallon Lin, Christina A Kirby, Markus Schirle, Gregg McAllister, Greg Hoffman, Nadire Ramadan, Anke Hartung, Yan Feng, David Randal Kipp, Christopher Quinn, Michelle Fodor, Jason Baird, Marie Schoumacher, Ronald Meyer, James Deeds, Gilles Buchwalter, Travis Stams, Nicholas Keen, William R Sellers, Myles Brown, Raymond A Pagliarini
Publikováno v:
eLife, Vol 5 (2016)
The TMPRSS2:ERG gene fusion is common in androgen receptor (AR) positive prostate cancers, yet its function remains poorly understood. From a screen for functionally relevant ERG interactors, we identify the arginine methyltransferase PRMT5. ERG recr
Externí odkaz:
https://doaj.org/article/c4fb9b17bde6451983fdc615d4bf193b
Autor:
Kimberly Malesky, Donald C. Lo, Guizhi Yang, Alice Loo, Hui Gao, Joshua M. Korn, Raymond Pagliarini, Brent R. Stockwell, Fallon Lin, Tom Mikkelsen, Eduard Reznik, Ana C. deCarvalho, Ling F. Ye
Publikováno v:
Oncotarget
There is a compelling need for new therapeutic strategies for glioblastoma multiforme (GBM). Preclinical target and therapeutic discovery for GBMs is primarily conducted using cell lines grown in serum-containing media, such as U-87 MG, which do not
Autor:
D. Randal Kipp, Craig Mickanin, Jeffery A. Porter, Albert Lai, Bing Zheng, Mark Stump, Yan Yan-Neale, John A. Tallarico, Young Shin Cho, Gregory R. Hoffman, Tobias Schmelzle, William R. Sellers, Samuel B. Ho, E. Robert McDonald, Kavitha Venkatesan, Yue Liu, Songping Zhao, Rosalie deBeaumont, Eric Billy, Ying Lin, Francesco Hofmann, Konstantinos J. Mavrakis, Vladimir Capka, Jianjun Yu, Antoine deWeck, Joshua T. McNamara, Emma Lees, Michael R. Schlabach, Hui Gao, Elizabeth R. Sprague, Nicholas Keen, Kristen Hurov, Kenneth Crawford, David A. Ruddy, David N. Ciccone, Guizhi Yang, Fallon Lin, Gregg McAllister, Justin Gu, Raymond Pagliarini, Alberto C. Vitari, Frank Stegmeier, Yingzi Yue, Hong Yin
Publikováno v:
Science. 351:1208-1213
Tumors put in a vulnerable position Cancer cells often display alterations in metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by creating new vulnerabilities that can be exploited