SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation

Autor: Bidault, G, Virtue, S, Petkevicius, K, Jolin, HE, Dugourd, A, Guenantin, AC, Leggat, J, Mahler-Araujo, B, Lam, BYH, Ma, MK, Dale, M, Carobbio, S, Kaser, A, Fallon, PG, Saez Rodriguez, J, McKenzie, ANJ, Vidal-Puig, A

Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation1. Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites2, improving insulin se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf6cb373be94b0f2cb363d3493ef6f8

Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

Autor: McKerrow, James, Leung, Jacqueline, McCune, Joseph, Broadhurst, MJ, Leung, JM, Lim, KC, Girgis, NM, Gundra, UM, Fallon, PG, Premenko-Lanier, M, McKerrow, JH, McCune, JM, Loke, P

Publikováno v: McKerrow, James; Leung, Jacqueline; McCune, Joseph; Broadhurst, MJ; Leung, JM; Lim, KC; et al.(2012). Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0zt3x35b

Although the vitamin A metabolite retinoic acid (RA) plays a critical role in immune function, RA synthesis during infection is poorly understood. Here, we show that retinal dehydrogenases (Raldh), required for the synthesis of RA, are induced during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::edc174bae3356289e37046c4c1a8c9d6
http://www.escholarship.org/uc/item/0zt3x35b

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