Differential transcription factor hub properties dictate gene-specific occupancy and transcriptional activity

Autor: Fallacaro, Samantha, Mukherjee, Apratim, Mir, Mustafa

Publikováno v: In Biophysical Journal 8 February 2024 123(3) Supplement 1:358a-358a

A fine kinetic balance of interactions directs transcription factor hubs to genes.

Autor: Fallacaro S; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia; Philadelphia, PA 19104, USA.; Developmental, Stem Cell, and Regenerative Biology Graduate Group, Perelman School of Medicine; Philadelphia, PA 19104, USA., Mukherjee A; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia; Philadelphia, PA 19104, USA., Ratchasanmuang P; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia; Philadelphia, PA 19104, USA.; Howard Hughes Medical Institute, Children's Hospital of Philadelphia; Philadelphia, PA 19104, USA., Zinski J; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia; Philadelphia, PA 19104, USA., Haloush YI; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia; Philadelphia, PA 19104, USA., Shankta K; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia; Philadelphia, PA 19104, USA.; Roy and Diana Vagelos Program in Life Sciences and Management, University of Pennsylvania; Philadelphia, PA 19104, USA., Mir M; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia; Philadelphia, PA 19104, USA.; Howard Hughes Medical Institute, Children's Hospital of Philadelphia; Philadelphia, PA 19104, USA.; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine; Philadelphia, PA 19104, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.