Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Falko Lange"'
Autor:
Falko Lange, Richard Gade, Anne Einsle, Katrin Porath, Gesine Reichart, Claudia Maletzki, Björn Schneider, Christian Henker, Daniel Dubinski, Michael Linnebacher, Rüdiger Köhling, Thomas M. Freiman, Timo Kirschstein
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe differentiation of high-grade glioma and brain tumors of an extracranial origin is eminent for the decision on subsequent treatment regimens. While in high-grade glioma, a surgical resection of the tumor mass is a fundamental part of cu
Externí odkaz:
https://doaj.org/article/dbe6cf8eeb524090a81b93767e6a50e6
Autor:
Elisabeth Schültke, Michael Lerch, Timo Kirschstein, Falko Lange, Katrin Porath, Stefan Fiedler, Jeremy Davis, Jason Paino, Elette Engels, Micah Barnes, Mitzi Klein, Christopher Hall, Daniel Häusermann, Guido Hildebrandt
Publikováno v:
Journal of Synchrotron Radiation, Vol 29, Iss 4, Pp 1027-1032 (2022)
Microbeam radiotherapy could help to cure malignant tumours which are currently still considered therapy-resistant. With an irradiation target in the thoracic cavity, the heart would be one of the most important organs at risk. To assess the acute ad
Externí odkaz:
https://doaj.org/article/7c4f0d17d2424fabbc38e89c641ee115
Autor:
Falko Lange, Katrin Porath, Tina Sellmann, Anne Einsle, Robert Jaster, Michael Linnebacher, Rüdiger Köhling, Timo Kirschstein
Publikováno v:
Biology, Vol 12, Iss 7, p 1032 (2023)
Several cues for a directional migration of colorectal cancer cells were identified as being crucial in tumor progression. However, galvanotaxis, the directional migration in direct-current electrical fields, has not been investigated so far. Therefo
Externí odkaz:
https://doaj.org/article/b33524b735304477832211c4cfb216e8
Autor:
Bernd Frerker, Stefan Fiedler, Timo Kirschstein, Falko Lange, Katrin Porath, Tina Sellmann, Leonie Kutzner, Fabian Wilde, Julian Moosmann, Rüdiger Köhling, Guido Hildebrandt, Elisabeth Schültke
Publikováno v:
Cells, Vol 12, Iss 1, p 176 (2022)
Background: High-dose-rate radiotherapy has shown promising results with respect to normal tissue preservation. We developed an ex vivo model to study the physiological effects of experimental radiotherapy in the rodent esophageal smooth muscle. Meth
Externí odkaz:
https://doaj.org/article/8710f0122d5c499786b0045983c125aa
Autor:
Julia Hörnschemeyer, Timo Kirschstein, Gesine Reichart, Christin Sasse, Jakob Venus, Anne Einsle, Katrin Porath, Michael Linnebacher, Rüdiger Köhling, Falko Lange
Publikováno v:
Life, Vol 12, Iss 8, p 1258 (2022)
Glioblastoma is the most common and aggressive primary brain tumor. Multiple genetic and epigenetic alterations in several major signaling pathways—including the phosphoinositide 3-kinases (PI3K)/AKT/mTOR and the Raf/MEK/ERK pathway—could be foun
Externí odkaz:
https://doaj.org/article/64c574a36cb848dcad686160cd9bb2c5
Autor:
Falko Lange, Jakob Venus, Daria Shams Esfand Abady, Katrin Porath, Anne Einsle, Tina Sellmann, Valentin Neubert, Gesine Reichart, Michael Linnebacher, Rüdiger Köhling, Timo Kirschstein
Publikováno v:
Life, Vol 12, Iss 4, p 580 (2022)
Galvanotaxis, the migration along direct current electrical fields, may contribute to the invasion of brain cancer cells in the tumor-surrounding tissue. We hypothesized that pharmacological perturbation of the epidermal growth factor (EGF) receptor
Externí odkaz:
https://doaj.org/article/97991a2cd81741d8b0ff5b05fb017a33
Autor:
Christian Junghanss, Daniel Palmer, Larissa Henze, Uwe Walter, Hugo Murua Escobar, Robert Jaster, Rüdiger Köhling, Falko Lange, Ali Salehzadeh-Yazdi, Olaf Wolkenhauer, Mohamed Hamed, Israel Barrantes, Steffen Möller, Axel Kowald, Nicole Heussen, Georg Fuellen
Publikováno v:
BMJ Open, Vol 10, Iss 12 (2020)
Introduction Ageing-related processes such as cellular senescence are believed to underlie the accumulation of diseases in time, causing (co)morbidity, including cancer, thromboembolism and stroke. Interfering with these processes may delay, stop or
Externí odkaz:
https://doaj.org/article/3b9f01331f0a4e70a175b18b3db08d6f
Autor:
Falko Lange, Jens Hartung, Clara Liebelt, Julius Boisserée, Tobias Resch, Katrin Porath, Max Frederik Hörnschemeyer, Gesine Reichart, Tina Sellmann, Valentin Neubert, Stephan Kriesen, Guido Hildebrandt, Elisabeth Schültke, Rüdiger Köhling, Timo Kirschstein
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
An abnormal glutamate signaling of glioblastoma may contribute to both tumor progression and the generation of glioma-associated epileptic seizures. We hypothesized that the AMPA receptor antagonist perampanel (PER) could attenuate tumor growth and e
Externí odkaz:
https://doaj.org/article/766c75cc8c414ac6959b68edd833ce6e
Publikováno v:
Cells, Vol 10, Iss 5, p 1226 (2021)
The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entit
Externí odkaz:
https://doaj.org/article/efebe6effa80440797dc9c440052f73b
AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro.
Autor:
Falko Lange, Konrad Weßlau, Katrin Porath, Julia Hörnschemeyer, Carina Bergner, Bernd Joachim Krause, Christina Susanne Mullins, Michael Linnebacher, Rüdiger Köhling, Timo Kirschstein
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211644 (2019)
Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is often necessary. While clinical guidelines recommend all approved anticonvulsants, so far it is still unclear which of the available drugs is the best ther
Externí odkaz:
https://doaj.org/article/1341d432fb1e4dfaa214f8e1a5e481a3