[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors

Autor: Lechner, Christian, Flaßhoff, Maren, Falke, Hannes, Preu, Lutz, Loaëc, Nadége, Meijer, Laurent, Knapp, Stefan, Chaikuad, Apirat, Kunick, Conrad

Publikováno v: Molecules
Molecules (Basel, Switzerland) 2019, 24(22), 4090; https://doi.org/10.3390/molecules24224090--Molecules--1420-3049--1420-3049
Volume 24
Issue 22

Since hyperactivity of the protein kinase DYRK1A is linked to several neurodegenerative disorders, DYRK1A inhibitors have been suggested as potential therapeutics for Down syndrome and Alzheimer&rsquo
s disease. Most published inhibitors to date

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::96be062709ec03f8bba576bd0e2bf8cb
http://europepmc.org/articles/PMC6891749

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design

Autor: Meine, Rosanna, Becker, Walter, Falke, Hannes, Preu, Lutz, Loaëc, Nadège, Meijer, Laurent, Kunick, Conrad

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules : a journal of synthetic chemistry and natural product chemistry / Molecular Diversity Preservation International 23(2), 64 (2018). doi:10.3390/molecules23020064
Molecules, Vol 23, Iss 2, p 64 (2018)

Molecules : a journal of synthetic chemistry and natural product chemistry / Molecular Diversity Preservation International 23(2), 64 (2018). doi:10.3390/molecules23020064
Published by MDPI, Basel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddbb99d9073bef9c61b194768cf674e1
http://europepmc.org/articles/PMC6017736

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