Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

Autor: Felipe Opazo, Laura Eiden, Line Hansen, Falk Rohrbach, Jesper Wengel, Jørgen Kjems, Günter Mayer

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)

Aptamers are valuable tools that provide great potential to develop cost-effective diagnostics and therapies in the biomedical field. Here, we report a novel DNA aptamer that folds into an unconventional G-quadruplex structure able to recognize and e

Externí odkaz: https://doaj.org/article/57184635e6e44f0cab1bd65a29a26d76

Aptamer-Guided Caging for Selective Masking of Protein Domains

Autor: Bernd Pötzsch, Florian Schäfer, Jens Müller, Alexander Heckel, Günter Mayer, Falk Rohrbach, Franziska Pfeiffer, Manuela A. H. Fichte

Publikováno v: Angewandte Chemie International Edition. 52:11912-11915

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a230e5b252102865f4808c070fb447ca
https://doi.org/10.1002/anie.201306686

Chemical Maturation of a Bivalent Aptamer by Single Domain Variation

Autor: Bernd Pötzsch, Michael B. Petersen, Maha I. Fatthalla, Günter Mayer, Falk Rohrbach, Erik B. Pedersen, Jens Müller, Tina Kupper

Publikováno v: Rohrbach, F, Fatthalla, M I, Kupper, T, Pötzsch, B, Müller, J, Petersen, M, Pedersen, E B & Mayer, G 2012, ' Chemical maturation of a bivalent aptamer by single domain variation ', ChemBioChem, vol. 13, no. 5, pp. 631-4 . https://doi.org/10.1002/cbic.201200015

Two-pronged attack: We describe the maturation of a bivalent aptamer by a chemically driven two-step process. From an improved monovalent aptamer subdomain that had been modified by polycyclic aromatic hydrocarbons at individual positions, a mature b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5666b3aa875b18ed1ea0c16b45ab8886
https://doi.org/10.1002/cbic.201200015

Aptamer-based modulation of blood coagulation

Autor: Bernd Pötzsch, Günter Mayer, Jens Müller, Falk Rohrbach

Publikováno v: Hämostaseologie. 31:258-263

SummaryNucleic acid based aptamers are singlestranded oligonucleotide ligands isolated from random libraries by an in-vitro selection procedure. Through the formation of unique three-dimensional structures, aptamers are able to selectively interact w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416e88c6ebecc2bcc333c53ec017ffdf
https://doi.org/10.5482/ha-1156

Light-controlled tools

Autor: Alexander Gottschalk, Falk Rohrbach, Günter Mayer, Clara Brieke, Alexander Heckel

Publikováno v: Angewandte Chemie (International ed. in English). 51(34)

Spatial and temporal control over chemical and biological processes plays a key role in life, where the whole is often much more than the sum of its parts. Quite trivially, the molecules of a cell do not form a living system if they are only arranged

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe49f98d55f91cf559ff614dae289aed
https://pubmed.ncbi.nlm.nih.gov/22829531