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2
Akademický článek
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Autor: Brooks HB; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA. brooks_harold@lilly.com., Meier TI; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Geeganage S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Fales KR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Thrasher KJ; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Konicek SA; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Spencer CD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Thibodeaux S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Foreman RT; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Hui YH; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Roth KD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Qian YW; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Wang T; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Luo S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Torrado A; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Si C; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Toth JL; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Mc Cowan JR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Frimpong K; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Lee MR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Dally RD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Shepherd TA; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Durham TB; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Wang Y; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Wu Z; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Iversen PW; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA., Njoroge FG; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Publikováno v: Scientific reports [Sci Rep] 2018 Oct 18; Vol. 8 (1), pp. 15458. Date of Electronic Publication: 2018 Oct 18.
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3
Akademický článek
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
Autor: Fales KR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Njoroge FG; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Brooks HB; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Thibodeaux S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Torrado A; Centro de Investigación Lilly , S. A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain., Si C; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Toth JL; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Mc Cowan JR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Roth KD; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Thrasher KJ; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Frimpong K; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Lee MR; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Dally RD; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Shepherd TA; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Durham TB; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wu Z; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wang Y; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Atwell S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Wang J; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Hui YH; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Meier TI; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Konicek SA; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States., Geeganage S; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 46285, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Dec 14; Vol. 60 (23), pp. 9599-9616. Date of Electronic Publication: 2017 Nov 09.
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4
Akademický článek
Enantioselective Synthesis of 3,3-Difluoropyrrolidin-4-ol, a Valuable Building Block in Medicinal Chemistry.
Autor: Si C; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Fales KR; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Torrado A; DCR&T, Lilly Spain S.A., Avda de la Industria 30, Alcobendas Madrid, 28108, Spain., Frimpong K; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Kaoudi T; DCR&T, Lilly Spain S.A., Avda de la Industria 30, Alcobendas Madrid, 28108, Spain., Vandeveer HG; AMRI, 26 Corporate Circle, Albany, New York 12203, United States., Njoroge FG; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
Publikováno v: The Journal of organic chemistry [J Org Chem] 2016 May 20; Vol. 81 (10), pp. 4359-63. Date of Electronic Publication: 2016 May 10.
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5
Akademický článek
A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models.
Autor: Yin T; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Lallena MJ; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Kreklau EL; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Fales KR; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Carballares S; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Torrres R; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Wishart GN; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Ajamie RT; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Cronier DM; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Iversen PW; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Meier TI; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Foreman RT; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Zeckner D; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Sissons SE; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Halstead BW; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Lin AB; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Donoho GP; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Qian Y; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Li S; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Wu S; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Aggarwal A; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Ye XS; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Starling JJ; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., Gaynor RB; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom., de Dios A; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom du_jian@lilly.com de_dios_alfonso@lilly.com., Du J; Authors' Affiliations: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana; Eli Lilly and Company, Alcobendas, Madrid, Spain; and Eli Lilly and Company, Windlesham, United Kingdom du_jian@lilly.com de_dios_alfonso@lilly.com.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2014 Jun; Vol. 13 (6), pp. 1442-56. Date of Electronic Publication: 2014 Mar 31.
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