Zobrazeno 1 - 10
of 492
pro vyhledávání: '"Falconer, Robert"'
Autor:
Barnieh, Francis M., Morais, Goreti R., Loadman, Paul, Falconer, Robert A., El-Khamisy, Sherif
Yes
Targeted therapy remains the future of anti-cancer drug development, owing to the lack of specificity of current treatments which lead to damage in healthy normal tissues. ATR inhibitors have in recent times demonstrated promising clinical p
Targeted therapy remains the future of anti-cancer drug development, owing to the lack of specificity of current treatments which lead to damage in healthy normal tissues. ATR inhibitors have in recent times demonstrated promising clinical p
Externí odkaz:
http://hdl.handle.net/10454/19982
Yes
Despite significant preclinical promise as anticancer agents, vascular-disrupting agents have yet to fulfil their clinical potential due to systemic toxicities. ICT2588 is a tumour-selective MT1-MMP-targeted prodrug of azademethylcolchicine,
Despite significant preclinical promise as anticancer agents, vascular-disrupting agents have yet to fulfil their clinical potential due to systemic toxicities. ICT2588 is a tumour-selective MT1-MMP-targeted prodrug of azademethylcolchicine,
Externí odkaz:
http://hdl.handle.net/10454/19633
Yes
The dysregulation of Membrane - type 1 matrix metalloproteinase (MT1-MMP) has been extensively studied in numerous cancer types, and plays key roles in angiogenesis, cancer progression, and metastasis. MT1-MMP is a predictor of poor prognosi
The dysregulation of Membrane - type 1 matrix metalloproteinase (MT1-MMP) has been extensively studied in numerous cancer types, and plays key roles in angiogenesis, cancer progression, and metastasis. MT1-MMP is a predictor of poor prognosi
Externí odkaz:
http://hdl.handle.net/10454/19637
Autor:
Guo, Xiaoxiao, Elkashef, Sara M., Patel, Anjana, Ribeiro Morais, Goreti, Shnyder, Steven, Loadman, Paul, Patterson, Laurence H., Falconer, Robert A.
Yes
Polysialic acid (polySia) is a linear polysaccharide comprised of N-acetylneuraminic acid residues and its over-expression in cancer cells has been correlated with poor clinical prognosis. An assay has been developed for quantitative analysi
Polysialic acid (polySia) is a linear polysaccharide comprised of N-acetylneuraminic acid residues and its over-expression in cancer cells has been correlated with poor clinical prognosis. An assay has been developed for quantitative analysi
Externí odkaz:
http://hdl.handle.net/10454/18344
Autor:
Guo, Xiaoxiao, Elkashelf, Sara M., Loadman, Paul, Patterson, Laurence H., Falconer, Robert A.
Yes
Polysialic acid (polySia) is a unique, well-characterised carbohydrate polymer highly-expressed on the cell surface of neurons in the early stages of mammalian brain development. Post-embryogenesis, it is also re-expressed in a number of tum
Polysialic acid (polySia) is a unique, well-characterised carbohydrate polymer highly-expressed on the cell surface of neurons in the early stages of mammalian brain development. Post-embryogenesis, it is also re-expressed in a number of tum
Externí odkaz:
http://hdl.handle.net/10454/17206
Yes
The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstr
The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstr
Externí odkaz:
http://hdl.handle.net/10454/18345
Yes
The disulfide bond plays an important role in the formation and stabilisation of higher order structures of peptides and proteins, while in recent years interest in this functional group has been extended to carbohydrate chemistry. Rarely fo
The disulfide bond plays an important role in the formation and stabilisation of higher order structures of peptides and proteins, while in recent years interest in this functional group has been extended to carbohydrate chemistry. Rarely fo
Externí odkaz:
http://hdl.handle.net/10454/18174
Autor:
Guo, Xiaoxiao, Malcolm, Jodie R., Ali, Marrwa M., Ribeiro Morais, Goreti, Shnyder, Steven, Loadman, Paul, Patterson, Laurence H., Falconer, Robert A.
Yes
The polysialyltransferases (polySTs) catalyse the polymerisation of polysialic acid, which plays an important role in tumour metastasis. While assays are available to assess polyST enzyme activity, there is no methodology available specifica
The polysialyltransferases (polySTs) catalyse the polymerisation of polysialic acid, which plays an important role in tumour metastasis. While assays are available to assess polyST enzyme activity, there is no methodology available specifica
Externí odkaz:
http://hdl.handle.net/10454/17821
Autor:
Wu, W., Klockow, J.L., Mohanty, S., Ku, K.S., Aghighi, M., Melemenidis, S., Chen, Z., Li, K., Ribeiro Morais, Goreti, Zhao, N., Schlegel, J., Graves, E.E., Rao, J., Loadman, Paul, Falconer, Robert A., Mukherjee, S., Chin, F.T., Daldrup-Link, H.E.
Yes
Despite considerable progress with our understanding of glioblastoma multiforme (GBM) and the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with tumor recurrence due to radioresistance being a major co
Despite considerable progress with our understanding of glioblastoma multiforme (GBM) and the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with tumor recurrence due to radioresistance being a major co
Externí odkaz:
http://hdl.handle.net/10454/17326
Autor:
Haggag, Y.A., Matchett, K.B., Falconer, Robert A., Isreb, Mohammad, Jones, Jason, Faheem, A., McCarron, P., El-Tanani, Mohamed
Yes
The delivery of anticancer agents to their subcellular sites of action is a significant challenge for effective cancer therapy. Peptides, which are integral to several oncogenic pathways, have significant potential to be utilised as cancer t
The delivery of anticancer agents to their subcellular sites of action is a significant challenge for effective cancer therapy. Peptides, which are integral to several oncogenic pathways, have significant potential to be utilised as cancer t
Externí odkaz:
http://hdl.handle.net/10454/17484