Informing a national rare disease registry strategy in Australia: a mixed methods study

Autor: Rasa Ruseckaite, Marisa Caruso, Chethana Mudunna, Falak Helwani, Nicole Millis, Susannah Ahern

Publikováno v: BMC Health Services Research, Vol 23, Iss 1, Pp 1-28 (2023)

Abstract Background Rare disease registries (RDRs) facilitate monitoring of rare diseases by pooling small datasets to increase clinical and epidemiological knowledge of rare diseases and promote patient centred best practice. The aim of this study w

Externí odkaz: https://doaj.org/article/5af61d21a6da48779f899fba5994a02e

B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2

Autor: Ingrid G. Winkler, Linda J. Bendall, Catherine E. Forristal, Falak Helwani, Bianca Nowlan, Valerie Barbier, Yi Shen, Adam Cisterne, Lisa M. Sedger, Jean-Pierre Levesque

Publikováno v: Haematologica, Vol 98, Iss 3 (2013)

Osteoblasts are necessary to B lymphopoiesis and mobilizing doses of G-CSF or cyclophosphamide inhibit osteoblasts, whereas AMD3100/Plerixafor does not. However, the effect of these mobilizing agents on B lymphopoiesis has not been reported. Mice (wi

Externí odkaz: https://doaj.org/article/51ee28237fbb40a39602d2411e1fffe8

PROSTACYCLIN IS A NOVEL HEMATOPOIETIC STEM CELL REGULATOR ENRICHED IN THE ENDOSTEAL BONE MARROW NICHE

Autor: Ingrid G. Winkler, Jean-Pierre Levesque, Valerie Barbier, Gareth Price, Joshua Tay, Falak Helwani

Publikováno v: Experimental Hematology. 76:S88

Potent functional HSCs are enriched at the endosteal bone marrow (BM), which comprises ∼10% of total BM. To identify novel niche factors that regulate HSCs, we performed a gene expression microarray seeking genes overexpressed in the endosteal rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c7923cbc1f96988f382c8f47ef1661d
https://doi.org/10.1016/j.exphem.2019.06.444

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Autor: Kylie A. Alexander, Nico van Rooijen, Bianca Nowlan, Jean-Pierre Levesque, Natalie A. Sims, Ingrid G. Winkler, Ingrid J. Poulton, Falak Helwani, Liza J. Raggatt, Valerie Barbier, Allison R. Pettit

Publikováno v: Winkler, I G, Sims, N A, Pettit, A R, Barbier, V, Nowlan, B, Helwani, F, Poulton, I J, van Rooijen, N, Alexander, K A, Raggatt, L J & Levesque, J P 2010, ' Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs ', Blood, vol. 116, no. 23, pp. 4815-4828 . https://doi.org/10.1182/blood-2009-11-253534
Blood, 116(23), 4815-4828. American Society of Hematology

In the bone marrow, hematopoietic stem cells (HSCs) reside in specific niches near osteoblast-lineage cells at the endosteum. To investigate the regulation of these endosteal niches, we studied the mobilization of HSCs into the bloodstream in respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd00b155c9e2fa8a81684ca7077ea1f9
https://doi.org/10.1182/blood-2009-11-253534

Cortactin Is a Functional Target of E-cadherin-activated Src Family Kinases in MCF7 Epithelial Monolayers

Autor: Suzie Verma, Alpha S. Yap, Robert W. McLachlan, Gang Ren, Scott A. Weed, Falak Helwani

Publikováno v: Journal of Biological Chemistry. 284:18913-18922

Src family kinases (SFKs) signal in response to E-cadherin to support cadherin adhesion and the integrity of cell-cell contacts (McLachlan, R. W., Kraemer, A., Helwani, F. M., Kovacs, E. M., and Yap, A. S. (2007) Mol. Biol. Cell 18, 3214–3223). We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93697319d147a28051a44d24d3e5b521
https://doi.org/10.1074/jbc.m109.000307