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The multifaceted role of cell cycle regulators in the coordination of growth and metabolism

Autor: Huber, K., Mestres-Arenas, A., Fajas, L., Leal-Esteban, L.C.

Publikováno v: The FEBS journal, vol. 288, no. 12, pp. 3813-3833

Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi-directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the famil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::7d0b37299c19a72cb95cc727ce46215e
https://serval.unil.ch/resource/serval:BIB_71F450E7C4FC.P001/REF.pdf

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Cdkn2a deficiency promotes adipose tissue browning

Autor: Rabhi, N., Hannou, S.A., Gromada, X., Salas, E., Yao, X., Oger, F., Carney, C., Lopez-Mejia, I.C., Durand, E., Rabearivelo, I., Bonnefond, A., Caron, E., Fajas, L., Dani, C., Froguel, P., Annicotte, J.S.

Publikováno v: Molecular Metabolism, Vol 8, Iss, Pp 65-76 (2018)
Molecular Metabolism
Molecular metabolism, vol. 8, pp. 65-76

Objectives Genome-wide association studies have reported that DNA polymorphisms at the CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) risk. Yet the causal relationship between this gene and defective energy hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::090c3400938126ef2f38db039b2821ba
http://www.sciencedirect.com/science/article/pii/S2212877817309353

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Akademický článek

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Cancer: Linking Powerhouses to Suicidal Bags

Autor: Martinez-Carreres, L., Nasrallah, A., Fajas, L.

Publikováno v: Frontiers in Oncology, vol. 7, pp. 204

Membrane-bound organelles are integrated into cellular networks and work together for a common goal: regulating cell metabolism, cell signaling pathways, cell fate, cellular maintenance, and pathogen defense. Many of these interactions are well estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::08876aa370b1ea5acb19add6b875c1ba
https://serval.unil.ch/resource/serval:BIB_030409EABA61.P001/REF.pdf

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E2F1, a Novel Regulator of Metabolism

Autor: Denechaud, P.D., Fajas, L., Giralt, A.

Publikováno v: Frontiers in endocrinology, vol. 8, pp. 311

In the past years, several lines of evidence have shown that cell cycle regulatory proteins also can modulate metabolic processes. The transcription factor E2F1 is a central player involved in cell cycle progression, DNA-damage response, and apoptosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::de8861aab3b3d87381e26787939c5697
https://serval.unil.ch/notice/serval:BIB_1D63D7156464

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Akademický článek

Metabolism and proliferation share common regulatory pathways in cancer cells.

Autor: Fritz, V.^1,2,3,4, Fajas, L.^1,2,3,4 lluis.fajas@inserm.fr

Publikováno v: Oncogene. 8/5/2010, Vol. 29 Issue 31, p4369-4377. 9p. 3 Diagrams.

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