Výsledky vyhledávání - "Faiza Kalfalah"

Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation

Autor: Hussam Ibrahim, Faiza Kalfalah, Anna-Lena Grothoff, Hans Reinke, Valerie Rudenko, Anja Stefanski, Christina Buschhaus, Niklas Berleth, Kai Stühler, Philipp Reus, Anna Katharina Mundorf, Björn Stork

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 3787, p 3787 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 7

Repressor protein period (PER) complexes play a central role in the molecular oscillator mechanism of the mammalian circadian clock. While the main role of nuclear PER complexes is transcriptional repression, much less is known about the functions of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4cce7f3a59a3537c66b341a61ac3e3
https://doi.org/10.3390/ijms22073787

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Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

Autor: Gereon Poschmann, Fritz Boege, Niels Grabe, Kai Stühler, Ellen Fritsche, Kai Safferling, Petra Boukamp, Ulrike Huebenthal, Françoise Bernerd, Christine Götz-Rösch, Julia Tigges, Faiza Kalfalah, Laura A. Haag, Jean Krutmann, Elena Volpi, Daniel M. Waldera Lupa

Publikováno v: Journal of Investigative Dermatology. 135(8):1954-1968

Most molecular hallmarks of cellular senescence have been identified in studies of cells aged in vitro by driving them into replicative or stress-induced senescence. Comparatively, less is known about the characteristic features of cells that have ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c63156e88e3c18368646e17046f989

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Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis

Autor: Christian Mielke, Elke Berg, Fritz Boege, Faiza Kalfalah, Morten O. Christensen, Wilhelm G. Dirks, René M. Linka

Publikováno v: Cell Cycle

To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c612d9e4627ba5d89f3a7f55207a5a
https://doi.org/10.1080/15384101.2014.1000182

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Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I

Autor: Christian Mielke, Heiner Schaal, Frank Hillebrand, Rudolf J. Wiesner, Ilaria Dalla Rosa, Fritz Boege, Morten O. Christensen, Stefan Sobek, Hongliang Zhang, Faiza Kalfalah, Beatrice Bornholz, Yves Pommier, Jürgen-Christoph von Kleist-Retzow

Publikováno v: Nucleic Acids Research

Mitochondrial topoisomerase I is a genetically distinct mitochondria-dedicated enzyme with a crucial but so far unknown role in the homeostasis of mitochondrial DNA metabolism. Here, we present data suggesting a negative regulatory function in mitoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ee8cf32a9791936540e52bda1c1a2b
https://doi.org/10.1093/nar/gkt768

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Rapid and prolonged stalling of human DNA topoisomerase I in UVA-irradiated genomic areas

Autor: Christian Mielke, Morten O. Christensen, Fritz Boege, Faiza Kalfalah

Publikováno v: DNA Repair. 6:1757-1763

DNA topoisomerase I appears to be involved in DNA damage and repair in a complex manner. The enzyme is required for DNA maintenance and repair, but it may also damage DNA through its covalently DNA-bound, catalytic intermediate. The latter mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9318d2e88b6dcf5294564125fb6de9
https://doi.org/10.1016/j.dnarep.2007.06.014

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Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors

Autor: Fritz Boege, Melanie Boerries, Alexander Bürkle, Brigitte Royer-Pokora, Maria Moreno-Villanueva, Hauke Busch, Sebastian Ohse, Julia Tigges, Barbara Hildebrandt, Sabine Seggewiß, Faiza Kalfalah, Regina Walter

Publikováno v: Aging (Albany NY)

Dermal fibroblasts provide a paradigmatic model of cellular adaptation to long-term exogenous stress and ageing processes driven thereby. Here we addressed whether fibroblast ageing analysed ex vivo entails genome instability. Dermal fibroblasts from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cf01dd87a7bb96111e01dfb3b13352
https://pubmed.ncbi.nlm.nih.gov/25678531

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Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation

Autor: René Deenen, Karl Köhrer, Beatrice Bornholz, Sebastian Ohse, Stefan Sobek, Faiza Kalfalah, Fritz Boege, Ellen Fritsche, Melanie Boerries, Jean Krutmann, Julia Tigges, Christine Götz-Rösch, Hauke Busch

Publikováno v: Experimental gerontology. 56

Extrinsic skin ageing converges on the dermis, a post-mitotic tissue compartment consisting of extracellular matrix and long-lived fibroblasts prone to damage accumulation and maladaptation. Aged human fibroblasts exhibit mitochondrial and nuclear dy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ecab332227266e6b2b08b0b9f593db
https://pubmed.ncbi.nlm.nih.gov/24699405

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The hallmarks of fibroblast ageing

Autor: Jean Krutmann, Hans Reinke, Sabrina Gundermann, Ellen Fritsche, Kai Stühler, Heiner Schaal, Julia Tigges, Petra Boukamp, Fritz Boege, Jens W. Fischer, Judith Haendeler, Faiza Kalfalah, Guido Reifenberger, Natascia Ventura

Publikováno v: Mechanisms of ageing and development. 138

Ageing is influenced by the intrinsic disposition delineating what is maximally possible and extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic ageing processes act on the dermis, a post-mitotic skin compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50171902afcc3982d06c1e41cea66a31
https://pubmed.ncbi.nlm.nih.gov/24686308

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Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence

Autor: Faiza Kalfalah, Simone Baechler, Doris Marko, Christian Mielke, Fritz Boege, Morten O. Christensen

Publikováno v: Molecular nutritionfood research. 55

Scope: DNA damage by genistein and etoposide is determined by the half-life of topoisomerase II–DNA linkage induced [Bandele O. J. and Osheroff N., Biochemistry 2008, 47, 11900]. Here, we test whether this applies generally to dietary flavonoids an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08875563339dba1893abb2c8f917baa
https://pubmed.ncbi.nlm.nih.gov/21520487

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Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

Autor: Ellen Fritsche, Julia Tigges, Daniel M. Waldera-Lupa, Fabian Kruse, Kai Stühler, Melanie Boerries, Ana-Maria Florea, Vera Rieder, Jean Krutmann, Guido Reifenberger, Hauke Busch, Fritz Boege, Steffen Sass, Helmut E. Meyer, Fabian J. Theis, Faiza Kalfalah

Publikováno v: Scopus-Elsevier
Europe PubMed Central
Aging (Albany NY)

We analyzed an ex vivo model of in situ aged human dermal fibroblasts, obtained from 15 adult healthy donors from three different age groups using an unbiased quantitative proteome-wide approach applying label-free mass spectrometry. Thereby, we iden

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http://www.scopus.com/inward/record.url?eid=2-s2.0-84922735547&partnerID=MN8TOARS

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