Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Faith P Dizon"'
Autor:
Wen-I Wu, Walter C Voegtli, Hillary L Sturgis, Faith P Dizon, Guy P A Vigers, Barbara J Brandhuber
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12913 (2010)
AKT1 (NP_005154.2) is a member of the serine/threonine AGC protein kinase family involved in cellular metabolism, growth, proliferation and survival. The three human AKT isozymes are highly homologous multi-domain proteins with both overlapping and d
Externí odkaz:
https://doaj.org/article/deb7442d250247b78775ee4e8843f54a
Autor:
Dengming Xiao, Matthew Martinson, Ian S. Mitchell, Keith Lee Spencer, Tyler Risom, Guy Vigers, James F. Blake, Lesley J. Murray, Susan L. Gloor, Nicholas J. Skelton, Rui Xu, Nicholas C. Kallan, Barbara J. Brandhuber, Wen-I Wu, Wei Wei Prior, Josef R. Bencsik, Richard Woessner, Faith P. Dizon
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(23)
Herein we report the discovery and synthesis of a novel series of dihydrothieno- and dihydrofuropyrimidines (2 and 3) as potent pan Akt inhibitors. Utilizing previous SAR and analysis of the amino acid sequences in the binding site we have designed i