Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Faith M, Strickland"'
Publikováno v:
Clinical Immunology. 196:97-102
Patients with active lupus have altered T cells characterized by low DNA methyltransferase levels. We hypothesized that low DNA methyltransferase levels synergize with low methionine levels to cause greater overexpression of genes normally suppressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2091d22699229dc9983fdd6cb915817f
https://doi.org/10.1016/j.clim.2018.04.003
https://doi.org/10.1016/j.clim.2018.04.003
Autor:
Patrick Coit, Shaylynn Miller, W. Joseph McCune, Mikhail Ognenovski, Paul Renauer, Pei-Suen Tsou, Elizabeth Gensterblum, Nathan C Kilian, Faith M. Strickland, Kathleen Maksimowicz-McKinnon, Amr H. Sawalha, Jonathan D. Wren, Emily E. Lewis, Bruce C. Richardson
Objective The goal of this study was to comprehensively characterize CD4+CD28+ T cells overexpressing CD11a and KIR genes, and examine the relationship between this T cell subset, genetic risk, and disease activity in lupus. Methods The size of the C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5cd416cf6a0f6654138a3c02f7ea79
https://europepmc.org/articles/PMC5821123/
https://europepmc.org/articles/PMC5821123/
Autor:
Miriam R. Anver, Frances P. Noonan, Faith M. Strickland, Agnieszka Wolnicka-Glubisz, Edward C. De Fabo, Albert R. Wielgus, Glenn Merlino
Publikováno v:
International Journal of Cancer. 136:752-760
Melanocortin 1 receptor (MC1R) signaling stimulates black eumelanin production through a cAMP-dependent pathway. MC1R polymorphisms can impair this process, resulting in a predominance of red phaeomelanin. The red hair, fair skin and UV sensitive phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd139e66df1a9bb9ddceb4d5a7f5bb77
https://doi.org/10.1002/ijc.29050
https://doi.org/10.1002/ijc.29050
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Lupus remains a poorly understood disease causing disability and early mortality in those affected. Familial clustering and the identification of genetic susceptibility loci indicate that genes contribute to lupus (1), but incomplete concordance in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71958f0ae2b737c27a86fa925daf67ed
https://doi.org/10.1002/art.38427
https://doi.org/10.1002/art.38427
Autor:
Barbara Mickelson, Raymond Yung, Bruce C. Richardson, Colin Delaney, Amr H. Sawalha, Kent J. Johnson, Ailing Wu, Anura Hewagama, Mark F. Hoeltzel, Faith M. Strickland
Publikováno v:
Arthritis & Rheumatism. 65:1872-1881
Objective Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the environment contributes by inhibiting T cell DNA methylation, causing overexpression of normally sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2312178ab5b20e8874b48af8a69cae4a
https://doi.org/10.1002/art.37967
https://doi.org/10.1002/art.37967
Autor:
W. Joseph McCune, Punsisi Liyanarachchi, Tania Gonzalez-Rivera, Emily C. Somers, Bruce Richardson, Anura Hewagama, Faith M. Strickland, Dipak R. Patel, Gabriela Gorelik
Publikováno v:
Journal of Autoimmunity. 41:60-71
Women develop lupus more frequently than men and the reason remains incompletely understood. Evidence that men with Klinefelter’s Syndrome (XXY) develop lupus at approximately the same rate as women suggests that a second X chromosome contributes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d431ada51ad2063ab835821f636fc23a
https://doi.org/10.1016/j.jaut.2012.12.006
https://doi.org/10.1016/j.jaut.2012.12.006
Autor:
Faith M. Strickland, Anura Hewagama, Qianjian Lu, Bruce C. Richardson, Amr H. Sawalha, Colin Delaney, Ailing Wu, Raymond Yung, Ryan Webb, Kent J. Johnson, Robert Hinderer
Publikováno v:
Journal of Autoimmunity. 38:J135-J143
Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appear to play significant roles in SLE pathogenesis. Env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66bed257b26e7bbbfb05e108a23d9f7
https://doi.org/10.1016/j.jaut.2011.11.001
https://doi.org/10.1016/j.jaut.2011.11.001
Autor:
Travis K. Hughes, W. Joseph McCune, Joan T. Merrill, R. Hal Scofield, Ajay Nadig, Faith M. Strickland, Amr H. Sawalha, Emily C. Somers, Bruce Richardson, Lu Wang
Publikováno v:
Journal of Autoimmunity. 38:J216-J222
Lupus is less common in men than women, and the reason is incompletely understood. Current evidence indicates that lupus flares when genetically predisposed individuals encounter environmental agents that trigger the disease, and that the environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08960b41cb97e3a8c45f661f94866dd1
https://doi.org/10.1016/j.jaut.2011.11.008
https://doi.org/10.1016/j.jaut.2011.11.008
Publikováno v:
Experimental Gerontology. 45:312-322
T cell DNA methylation levels decline with age, activating genes such as KIR and TNFSF7 (CD70), implicated in lupus-like autoimmunity and acute coronary syndromes. The mechanisms causing age-dependent DNA demethylation are unclear. Maintenance of DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8d6d8183127fc07bbbbcb6985a5b48
https://doi.org/10.1016/j.exger.2009.12.008
https://doi.org/10.1016/j.exger.2009.12.008
Autor:
Jared Klarquist, Andreas Overbeck, Derek A. Wainwright, Faith M. Strickland, Cecele J. Denman, I. Caroline Le Poole, Michael I. Nishimura, Shikar Mehrotra, Claudia Hernandez
Publikováno v:
Pigment Cell & Melanoma Research. 23:276-286
In human vitiligo, cutaneous depigmentation involves cytotoxic activity of autoreactive T cells. It was hypothesized that depigmentation can progress in the absence of regulatory T cells (Treg). The percentage of Treg among skin infiltrating T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7933c6bdbec792a856c8c9839cb6f27c
https://doi.org/10.1111/j.1755-148x.2010.00688.x
https://doi.org/10.1111/j.1755-148x.2010.00688.x