CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis.

Autor: Faith Hall-Glenn, R Andrea De Young, Bau-Lin Huang, Ben van Handel, Jennifer J Hofmann, Tom T Chen, Aaron Choi, Jessica R Ong, Paul D Benya, Hanna Mikkola, M Luisa Iruela-Arispe, Karen M Lyons

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30562 (2012)

CCN2/Connective Tissue Growth Factor (CTGF) is a matricellular protein that regulates cell adhesion, migration, and survival. CCN2 is best known for its ability to promote fibrosis by mediating the ability of transforming growth factor β (TGFβ) to

Externí odkaz: https://doaj.org/article/c9188197a81f442bb161d3ab4a6bcd26

Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis

Autor: Jeffrey C. Lotz, Tristan W. Fowler, Claire Acevedo, Tamara Alliston, Faith Hall-Glenn, Aaron J. Fields, Hrishikesh Bale, Thomas P. Vail, Courtney M. Mazur, Robert O. Ritchie

Publikováno v: Fowler, TW; Acevedo, C; Mazur, CM; Hall-Glenn, F; Fields, AJ; Bale, HA; et al.(2017). Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis. Scientific Reports, 7. doi: 10.1038/srep44618. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7hv9m6kg
Scientific reports, vol 7, iss 1
Scientific Reports

Through a process called perilacunar remodeling, bone-embedded osteocytes dynamically resorb and replace the surrounding perilacunar bone matrix to maintain mineral homeostasis. The vital canalicular networks required for osteocyte nourishment and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc38c63ce698ccc4a99d524ded1e6e63
http://www.escholarship.org/uc/item/7hv9m6kg

Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia

Autor: Edward C. Hsiao, Wenhan Chang, Omar Akil, Lawrence R. Lustig, Tamara Alliston, Faith Hall-Glenn, Alfred Li, Jolie L. Chang

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e94989 (2014)
PLoS ONE

Normal hearing requires exquisite cooperation between bony and sensorineural structures within the cochlea. For example, the inner ear secretes proteins such as osteoprotegrin (OPG) that can prevent cochlear bone remodeling. Accordingly, diseases tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6df6446a39af5d6a6fc68cd6390a024
http://europepmc.org/articles/PMC4006800?pdf=render

CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress

Autor: Jessica R. Ong, Armen Aivazi, Ruth R. Baxter, Paul D. Benya, Roel Goldschmeding, Ernst B. Hunziker, Lusi Akopyan, Faith Hall-Glenn, Frans A. van Nieuwenhoven, Karen M. Lyons

Publikováno v: Hall-Glenn, Faith; Aivazi, Armen; Akopyan, Lusi; Ong, Jessica R.; Baxter, Ruth R.; Benya, Paul D.; Goldschmeding, Roel; van Nieuwenhoven, Frans A.; Hunziker, Ernst B.; Lyons, Karen M. (2013). CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress. Journal of cell communication and signaling, 7(3), pp. 219-30. Springer 10.1007/s12079-013-0201-y
Journal of Cell Communication and Signaling, 7(3), 219-30. Springer
Journal of cell communication and signaling, vol 7, iss 3
Journal of Cell Communication and Signaling

CCN2 (connective tissue growth factor (CTGF/CCN2)) is a matricellular protein that utilizes integrins to regulate cell proliferation, migration and survival. The loss of CCN2 leads to perinatal lethality resulting from a severe chondrodysplasia. Upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89406de95e89cb23ee3efbac487f8741