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Trichloroethylene exposure in mid-pregnancy decreased fetal weight and increased placental markers of oxidative stress in rats

Autor: Anjana Kumar, Lawrence H. Lash, Rita Loch-Caruso, Iman Hassan, Sean M. Harris, Faith Bjork

Publikováno v: Reproductive Toxicology. 83:38-45

Although epidemiology studies have associated maternal trichloroethylene (TCE) exposure with decreased birth weight and preterm birth, mechanistic explanations for these associations are currently lacking. We hypothesized that TCE targets the placent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e371f5371096610dae9a7591f38902
https://doi.org/10.1016/j.reprotox.2018.11.002

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N-Acetyl-L-cysteine and aminooxyacetic acid differentially modulate trichloroethylene reproductive toxicity via metabolism in Wistar rats

Autor: Ingrid L. Bergin, Anthony L. Su, Lawrence H. Lash, Faith Bjork, Rita Loch-Caruso

Publikováno v: Arch Toxicol

Exposure to the industrial solvent trichloroethylene (TCE) has been associated with adverse pregnancy outcomes in humans and decreased fetal weight in rats. TCE kidney toxicity can occur through formation of reactive metabolites via its glutathione (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be2df9d41a6575d5ea267c591f398d1
https://pubmed.ncbi.nlm.nih.gov/33599830

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