Corrigendum: The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: a 1H-MRS study in first-episode psychosis patients

Autor: Uzma Zahid, Robert A. McCutcheon, Faith Borgan, Sameer Jauhar, Fiona Pepper, Matthew M. Nour, Maria Rogdaki, Martin Osugo, Graham K. Murray, Pamela Hathway, Robin M. Murray, Alice Egerton, Oliver D. Howes

Publikováno v: Frontiers in Psychiatry, Vol 15 (2024)

Externí odkaz: https://doaj.org/article/a972f72c0e8346ab950623456976cfbe

N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study

Autor: Katherine Beck, Atheeshaan Arumuham, Mattia Veronese, Barbara Santangelo, Colm J. McGinnity, Joel Dunn, Robert A. McCutcheon, Stephen J. Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, James Stone, Sameer Jauhar, Teresa Sementa, Federico Turkheimer, Alexander Hammers, Oliver D. Howes

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched health

Externí odkaz: https://doaj.org/article/01e5daca97374a1c9b30a252f899148c

The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [18F]-FDOPA imaging in schizophrenia

Autor: Ilinca Angelescu, Stephen J Kaar, Tiago Reis Marques, Faith Borgan, Mattia Veronesse, Alice Sharman, Anil Sajjala, Bill Deakin, John Hutchison, Charles Large, Oliver D Howes

Publikováno v: Journal of Psychopharmacology

Background: Current treatments for schizophrenia act directly on dopamine (DA) receptors but are ineffective for many patients, highlighting the need to develop new treatment approaches. Striatal DA dysfunction, indexed using [18F]-FDOPA imaging, is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda5b831ae657a9288f260cca311bffe
https://doi.org/10.1177/02698811221122031

The association between N-methyl-d-aspartate receptor availability and glutamate levels:A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls

Autor: Katherine Beck, Atheeshaan Arumuham, Stefan Brugger, Robert A McCutcheon, Mattia Veronese, Barbara Santangelo, Colm J McGinnity, Joel Dunn, Stephen Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, Teresa Sementa, Radhouene Neji, Sameer Jauhar, Franklin Aigbirhio, Istvan Boros, Federico Turkheimer, Alexander Hammers, David Lythgoe, James Stone, Oliver D Howes

Publikováno v: Beck, K, Arumuham, A, Brugger, S, McCutcheon, R A, Veronese, M, Santangelo, B, McGinnity, C J, Dunn, J, Kaar, S, Singh, N, Pillinger, T, Borgan, F, Sementa, T, Neji, R, Jauhar, S, Aigbirhio, F, Boros, I, Turkheimer, F, Hammers, A, Lythgoe, D, Stone, J & Howes, O D 2022, ' The association between N-methyl-d-aspartate receptor availability and glutamate levels : A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls ', Journal of psychopharmacology (Oxford, England), vol. 36, no. 9, pp. 1051-1060 . https://doi.org/10.1177/02698811221099643

Background: Evidence from post-mortem studies and in vivo imaging studies suggests there may be reduced N-methyl-d-aspartate receptor (NMDAR) levels in the hippocampus in patients with schizophrenia. Other studies have reported increased glutamate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6447a0ee7a2d68ead15c25c3f70e79e7
https://kclpure.kcl.ac.uk/ws/files/184987017/The_association_between_BECK_Publishedonline19September2022_GREEN_AAM.pdf

GABA-A receptor differences in schizophrenia: a positron emission tomography study using [11C]Ro154513

Autor: Ilinca Angelescu, Oliver D. Howes, Federico Turkheimer, Anne Lingford-Hughes, Jim Myers, Tiago Reis Marques, David J. Nutt, Faith Borgan, Mattia Veronese, Abhishekh Hulegar Ashok

Publikováno v: Reis Marques, T, Borgan, F, Ashok, A H, Ureche-Angelescu, I, Meyers, J, Lingford-Hughes, A, Nutt, D, Veronese, M, Turkheimer, F E & Howes, O 2020, ' GABA-A receptor differences in Schizophrenia : A Positron Emission Tomography study using [11C]Ro154513 ', Molecular Psychiatry, vol. 0, no. 0, pp. 1-10 . https://doi.org/10.1038/s41380-020-0711-y

A loss of GABA signaling is a prevailing hypothesis for the pathogenesis of schizophrenia. Preclinical studies indicate that blockade of the α5 subtype of the GABA receptor (α5-GABAARs) leads to behavioral phenotypes associated with schizophrenia,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd90d49c32c1be41638d2e0bb6498a5
https://doi.org/10.1038/s41380-020-0711-y