Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

Autor: Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.

Publikováno v: Cell Reports, Vol 22, Iss 13, Pp 3641-3659 (2018)
Cell Reports

Summary Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that differentiation is induced through blockade of LSD1’s histone demethylase activity. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::294be72efe0d1dc7d26015f87ba3d107
http://www.sciencedirect.com/science/article/pii/S2211124718303413

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

Autor: Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

Publikováno v: European Journal of Medicinal Chemistry

Deregulation of the receptor tyrosine kinase RET has been implicated in medullary thyroid cancer, a small percentage of lung adenocarcinomas, endocrine-resistant breast cancer and pancreatic cancer. There are several clinically approved multi-kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2f24501b5885633937c91ec64f862432
https://pubmed.ncbi.nlm.nih.gov/26874741

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases.

Autor: Venkat A; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Watterson G; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Byrne DP; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., O'Boyle B; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Shrestha S; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA., Gravel N; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA., Fairweather EE; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Daly LA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK.; Centre for Proteome Research, Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Bunn C; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Yeung W; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA., Aggarwal I; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Katiyar S; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Eyers CE; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK.; Centre for Proteome Research, Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Eyers PA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Kannan N; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.; Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 18. Date of Electronic Publication: 2023 Jul 18.