Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk

Autor: Pelin Ünal, Ye Lu, Bas Bueno-de-Mesquita, Casper H. J. van Eijck, Renata Talar-Wojnarowska, Andrea Szentesi, Maria Gazouli, Edita Kreivenaite, Francesca Tavano, Ewa Małecka-Wojciesko, Bálint Erőss, Martin Oliverius, Stefania Bunduc, Mateus Nóbrega Aoki, Ludmila Vodickova, Ugo Boggi, Matteo Giaccherini, Jurate Kondrackiene, Roger Chammas, Orazio Palmieri, George E. Theodoropoulos, Maarten F. Bijlsma, Daniela Basso, Beatrice Mohelnikova-Duchonova, Pavel Soucek, Jakob R. Izbicki, Vytautas Kiudelis, Giuseppe Vanella, Paolo Giorgio Arcidiacono, Barbara Włodarczyk, Thilo Hackert, Ben Schöttker, Faik G. Uzunoglu, Franco Bambi, Mara Goetz, Viktor Hlavac, Hermann Brenner, Francesco Perri, Silvia Carrara, Stefano Landi, Péter Hegyi, Frederike Dijk, Evaristo Maiello, Giovanni Capretti, Sabrina Gloria Giulia Testoni, Maria Chiara Petrone, Hannah Stocker, Stefano Ermini, Livia Archibugi, Manuel Gentiluomo, Giulia Martina Cavestro, Raffaele Pezzilli, Gregorio Di Franco, Anna Caterina Milanetto, Cosimo Sperti, John P. Neoptolemos, Luca Morelli, Klara Vokacova, Claudio Pasquali, Rita T. Lawlor, Francesca Bazzocchi, Juozas Kupcinskas, Gabriele Capurso, Daniele Campa, Federico Canzian

Publikováno v: Human Genomics, Vol 18, Iss 1, Pp 1-12 (2024)

Abstract Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict

Externí odkaz: https://doaj.org/article/367f18caef8a4d1694535431727c275d

Tumor-Stroma Interaction in PDAC as a New Approach for Liquid Biopsy and its Potential Clinical Implications

Autor: Julian Götze, Christine Nitschke, Faik G. Uzunoglu, Klaus Pantel, Marianne Sinn, Harriet Wikman

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

The extremely poor prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) has remained unchanged for decades. As a hallmark of PDAC histology, the distinct desmoplastic response in the tumor microenvironment is considered a key factor ex

Externí odkaz: https://doaj.org/article/467dabdb5eba492bbdb914f65655bd4b

Circulating Cancer Associated Macrophage-like Cells as a Potential New Prognostic Marker in Pancreatic Ductal Adenocarcinoma

Autor: Christine Nitschke, Benedikt Markmann, Leonie Konczalla, Jolanthe Kropidlowski, Thais Pereira-Veiga, Pasquale Scognamiglio, Martin Schönrock, Marianne Sinn, Marie Tölle, Jakob Izbicki, Klaus Pantel, Faik G. Uzunoglu, Harriet Wikman

Publikováno v: Biomedicines, Vol 10, Iss 11, p 2955 (2022)

Background: Circulating Cancer Associated Macrophage-like cells (CAMLs) have been described as novel liquid biopsy analytes and unfavorable prognostic markers in some tumor entities, with scarce data for Pancreatic Ductal Adenocarcinomas (PDAC). Meth

Externí odkaz: https://doaj.org/article/cd0cee1a519f47e4ae0d74c5b114a9fb

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Autor: Joseph Tintelnot, Yang Xu, Till R. Lesker, Martin Schönlein, Leonie Konczalla, Anastasios D. Giannou, Penelope Pelczar, Dominik Kylies, Victor G. Puelles, Agata A. Bielecka, Manuela Peschka, Filippo Cortesi, Kristoffer Riecken, Maximilian Jung, Lena Amend, Tobias S. Bröring, Marija Trajkovic-Arsic, Jens T. Siveke, Thomas Renné, Danmei Zhang, Stefan Boeck, Till Strowig, Faik G. Uzunoglu, Cenap Güngör, Alexander Stein, Jakob R. Izbicki, Carsten Bokemeyer, Marianne Sinn, Alec C. Kimmelman, Samuel Huber, Nicola Gagliani

Publikováno v: Tintelnot, J, Xu, Y, Lesker, T R, Schönlein, M, Konczalla, L, Giannou, A D, Pelczar, P, Kylies, D, Puelles, V G, Bielecka, A A, Peschka, M, Cortesi, F, Riecken, K, Jung, M, Amend, L, Bröring, T S, Trajkovic-Arsic, M, Siveke, J T, Renné, T, Zhang, D, Boeck, S, Strowig, T, Uzunoglu, F G, Güngör, C, Stein, A, Izbicki, J R, Bokemeyer, C, Sinn, M, Kimmelman, A C, Huber, S & Gagliani, N 2023, ' Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer ', Nature, vol. 615, no. 7950, pp. 168-174 . https://doi.org/10.1038/s41586-023-05728-y

Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment1,2. Less than half of all patients respond to the primary treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6958462eedf5593c667bb2b17214d3f0
https://doi.org/10.1038/s41586-023-05728-y

Peripheral and Portal Venous KRAS ctDNA Detection as Independent Prognostic Markers of Early Tumor Recurrence in Pancreatic Ductal Adenocarcinoma

Autor: Christine Nitschke, Benedikt Markmann, Philipp Walter, Anita Badbaran, Marie Tölle, Jolanthe Kropidlowski, Yassine Belloum, Mara R Goetz, Jan Bardenhagen, Louisa Stern, Joseph Tintelnot, Martin Schönlein, Marianne Sinn, Paul van der Leest, Ronald Simon, Asmus Heumann, Jakob R Izbicki, Klaus Pantel, Harriet Wikman, Faik G Uzunoglu

Publikováno v: Clinical chemistry, 69(3), 295-307. AMER ASSOC CLINICAL CHEMISTRY

BackgroundKRAS circulating tumor DNA (ctDNA) has shown biomarker potential for pancreatic ductal adenocarcinoma (PDAC) but has not been applied in clinical routine yet. We aim to improve clinical applicability of ctDNA detection in PDAC and to study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c4a70b01fe25fe139b71c483ff4d53
https://research.rug.nl/en/publications/94671e44-38e8-4279-aaf7-defc1660777b