Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Fahumiya Samad"'
Autor:
Lindsey A. Miles, Hongdong Bai, Sagarika Chakrabarty, Nagyung Baik, Yuqing Zhang, Robert J. Parmer, Fahumiya Samad
Publikováno v:
Adipocyte, Vol 12, Iss 1 (2023)
ABSTRACTThe plasminogen receptor, Plg-RKT, is a unique cell surface receptor that is broadly expressed in cells and tissues throughout the body. Plg-RKT localizes plasminogen on cell surfaces and promotes its activation to the broad-spectrum serine p
Externí odkaz:
https://doaj.org/article/07f18effa3a140c2a8a4d63cb148d7f0
Autor:
Sagarika Chakrabarty, Quyen Bui, Leylla Badeanlou, Kelly Hester, Jerold Chun, Wolfram Ruf, Theodore P Ciaraldi, Fahumiya Samad
Publikováno v:
Adipocyte, Vol 11, Iss 1, Pp 69-83 (2022)
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that interacts via 5 G-protein coupled receptors, S1PR1-5, to regulate signalling pathways critical to biological processes including cell growth, immune cell trafficking, and inflammation.We
Externí odkaz:
https://doaj.org/article/b5842b2215f440ccb953cfdf3e9745aa
Autor:
Manuel Sanchez-Alavez, Nikki Bortell, Liana Basova, Fahumiya Samad, Maria Cecilia Garibaldi Marcondes
Publikováno v:
International Journal of Hyperthermia, Vol 37, Iss 1, Pp 1368-1382 (2020)
Hyperthermia is a potentially lethal side-effect of Methamphetamine (Meth), a stimulant drug. Activation of non-shivering thermogenesis in brown adipose tissue (BAT) is partly responsible for Meth-induced rise in temperature, with contributing sympat
Externí odkaz:
https://doaj.org/article/a74782fc95aa4250a61ead48ec046106
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 9, Pp 1852-1862 (2009)
Studies in skeletal muscle demonstrate that elevation of plasma FFAs increases the sphingolipid ceramide. We aimed to determine the impact of FFA oversupply on total sphingolipid profiles in a skeletal muscle model. C2C12 myotubes were treated with p
Externí odkaz:
https://doaj.org/article/a559e37eb2c844be9eaf40b717f2c645
Tissue Factor Expression in Obese Type 2 Diabetic Subjects and Its Regulation by Antidiabetic Agents
Publikováno v:
Journal of Obesity, Vol 2015 (2015)
Objective. Increased coagulation activation may contribute to the high incidence of cardiovascular complications observed in obese and type 2 diabetes (T2D) subjects. Although tissue factor (TF), the primary initiator of coagulation is increased in o
Externí odkaz:
https://doaj.org/article/2358d8e375954ee68648d8d10011439e
Autor:
Nikki Bortell, Maria Cecilia Garibaldi Marcondes, Liana Basova, Fahumiya Samad, Manuel Sanchez-Alavez
Publikováno v:
International Journal of Hyperthermia, Vol 37, Iss 1, Pp 1368-1382 (2020)
Hyperthermia is a potentially lethal side-effect of Methamphetamine (Meth), a stimulant drug. Activation of non-shivering thermogenesis in brown adipose tissue (BAT) is partly responsible for Meth-induced rise in temperature, with contributing sympat
Autor:
Fahumiya Samad, Hongdong Bai, Nagyung Baik, Patrick Haider, Yuqing Zhang, Gersina Rega‐Kaun, Christoph Kaun, Manfred Prager, Johann Wojta, Quyen Bui, Sagarika Chakrabarty, Jing Wang, Robert J. Parmer, Lindsey A. Miles
Publikováno v:
J Thromb Haemost
BACKGROUND: Plg-R(KT), a unique transmembrane plasminogen receptor, enhances the activation of plasminogen to plasmin, and localizes the proteolytic activity of plasmin on the cell surface. OBJECTIVES: We investigated the role of Plg-R(KT) in adipose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf91f6053bc60722eadd65bac959b5d
https://europepmc.org/articles/PMC8885904/
https://europepmc.org/articles/PMC8885904/
Publikováno v:
The American Journal of Pathology. 185:524-535
Failure to inhibit hepatic gluconeogenesis is a major mechanism contributing to fasting hyperglycemia in type 2 diabetes and, along with steatosis, is the hallmark of hepatic insulin resistance. Obesity is associated with chronic inflammation in mult
Autor:
Wolfram Ruf, Fahumiya Samad
Publikováno v:
Hämostaseologie. 35:279-283
SummaryObesity is a major cause for a spectrum of metabolic syndrome-related diseases that include insulin resistance, type 2 diabetes, and steatosis of the liver. Inflammation elicited by macrophages and other immune cells contributes to the metabol
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 306:E756-E768
Adipose dysfunction resulting from chronic inflammation and impaired adipogenesis has increasingly been recognized as a major contributor to obesity-mediated insulin resistance, but the molecular mechanisms that maintain healthy adipocytes and limit