Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Fahui Li"'
Autor:
Weiguo Song, Hekai Yang, Ying Wang, Shuzhen Chen, Wenda Zhong, Qian Wang, Wenshuo Ding, Guangzhao Xu, Chen Meng, Ying Liang, Zhe‐Sheng Chen, Shuhua Cao, Liuya Wei, Fahui Li
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract Multi‐drug resistance (MDR) is a major cause of cancer therapy failure. Photodynamic therapy (PDT) is a promising modality that can circumvent MDR and synergize with chemotherapies, based on the generation of reactive oxygen species (ROS)
Externí odkaz:
https://doaj.org/article/dfe4096d398d4ba78db0668db03a63d9
Autor:
Tianxin Wang, Wenqin Tang, Ziyi Zhao, Ran Zhao, Zhenyu Lv, Xuzhen Guo, Quanchang Gu, Boxiang Liu, Haoyu Lv, Jiayan Chen, Kaiquan Zhang, Fahui Li, Jiangyun Wang
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract The G‐protein‐coupled human cannabinoid receptor 1 (CB1) is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders. The structures of CB1‐Gi complexes in synthetic agonist‐bound forms
Externí odkaz:
https://doaj.org/article/30365fbeb6904c4dad4d657e84dc1973
Autor:
Hekai Yang, Fahui Li, Shuzhen Chen, Shanshan Jin, Weiwei Chen, Wen Sun, Liuya Wei, Guangzhao Xu, Weiguo Song, Wenda Zhong
Publikováno v:
Materials & Design, Vol 237, Iss , Pp 112566- (2024)
The excessive production of reactive oxygen species (ROS) can damage the mitochondrial membrane and induce apoptosis, causing endoplasmic reticulum stress and triggering immunogenic cell death. Therefore, the combination of apoptosis and immunogenic
Externí odkaz:
https://doaj.org/article/fd4a3caef874460798227fb24b9d2435
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2017-2035 (2022)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel therapeutic target for the development of cholesterol-lowering drugs. In the discovery of PCSK9/LDLR (low-density lipoprotein receptor) protein-protein interaction (PPI) imp
Externí odkaz:
https://doaj.org/article/129b00b9976348b4aecdcba4abb39973
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1918-1927 (2022)
Histone deacetylases (HDACs) are validated targets for the development of anticancer drugs in epigenetics. In the discovery of novel HDAC inhibitors with anticancer potency, the 5-chloro-4-((substituted phenyl)amino)pyrimidine fragment is assembled a
Externí odkaz:
https://doaj.org/article/10b08077a99545c6bd04fa8660e31c54
Autor:
Fahui Li, Congying Gao, Xueming Li, Jiangyun Wang, Yao Zhao, Yu Ke, Ying Liu, Hong-Min Liu, Zhenbo Hu, Liuya Wei, Zhe-Sheng Chen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Acute myeloid leukemia (AML) is an aggressive form of hematological neoplasia characterized by failure of myeloid differentiation. AML is a leading cause of death from leukemia. Cytarabine chemotherapy resistance is a major source of refractory/relap
Externí odkaz:
https://doaj.org/article/e4fa6642582749a0ae97a5325020f462
Autor:
Xiaoyan Xing, Fahui Li, Yajie Hu, Lin Zhang, Qian Hui, Hongyu Qin, Qixiao Jiang, Wenyan Jiang, Chunyan Fang, Lei Zhang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Aminopeptidase N (APN, CD13) is closely associated with the development and progression of cancer. Previous studies suggested APN as a biomarker for cancer stem cells. APN inhibitors have been intensively evaluated as chemosensitizers for cancer trea
Externí odkaz:
https://doaj.org/article/50ae3188d2f345d1ad23879b24174dfe
Publikováno v:
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-15 (2020)
Abstract Purpose Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis (Mtb), which often parasites in macrophages. This study is performed to investigate the bactericidal effect and underlying mechanisms of low-freque
Externí odkaz:
https://doaj.org/article/8a703ec7e9c841f1875752e9e9b770ec
Autor:
Bin Xia, Ping Lin, Yubin Ji, Jiayu Yin, Jin Wang, Xiaoqian Yang, Ting Li, Zixun Yang, Fahui Li, Shoudong Guo
Publikováno v:
Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-9 (2020)
Abstract Background The LDL-C lowering effect of ezetimibe has been attributed primarily to increased catabolism of LDL-C via up-regulation of LDL receptor (LDLR) and decreased cholesterol absorption. Recently, ezetimibe has been demonstrated to have
Externí odkaz:
https://doaj.org/article/2511b96f1bed49de9aa64a2c0ed8da64
Autor:
Shuhua Cao, Fahui Li, Qian Xu, Meng Yao, Shun Wang, Yunjun Zhou, Xiaotong Cui, Ruolin Man, Kaoxue Li, Xishi Tai
Publikováno v:
Journal of Saudi Chemical Society, Vol 25, Iss 12, Pp 101372- (2021)
A novel tetranuclear copper complex (TCC) has been successfully synthesized and characterized using high resolution mass spectrometry (HRMS), Fourier transform infrared spectroscopy (FTIR) and X-ray single crystal diffraction technique. TCC was capab
Externí odkaz:
https://doaj.org/article/14d1185bc389491ea8c780b7ea2bf2f9