Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Fahua She"'
Publikováno v:
International Journal of Clinical Pharmacology and Therapeutics
Objective To characterize the absorption, distribution, metabolism, and excretion of naloxegol, a PEGylated derivative of the µ-opioid antagonist naloxone, in healthy male subjects. Materials and methods [14C]-Labeled naloxegol (27 mg, 3.43 MBq) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a277385a9fe5affd1e72bfec54289b8
http://europepmc.org/articles/PMC4564822
http://europepmc.org/articles/PMC4564822
Publikováno v:
The Journal of Clinical Pharmacology. 54:1375-1382
The impact of renal impairment on the pharmacokinetics of a 25-mg oral dose of naloxegol was examined in patients with renal impairment classified as moderate, severe, or end-stage renal disease (ESRD) and compared with healthy subjects (n = 8/group)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35559bd037f79d9d29782b1a3c65ca85
https://doi.org/10.1002/jcph.349
https://doi.org/10.1002/jcph.349
Publikováno v:
International Journal of Geriatric Psychiatry. 28:615-625
Objective The objective of the study was to evaluate once-daily extended release quetiapine fumarate (quetiapine XR) monotherapy in older patients with generalized anxiety disorder (GAD). Methods An 11-week (9-week treatment; 2-week posttreatment), r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1583b5bc18013c1d31bc2b6519958c45
https://doi.org/10.1002/gps.3867
https://doi.org/10.1002/gps.3867
Publikováno v:
International Clinical Psychopharmacology. 27:40-54
The main objective of this study was to evaluate efficacy and tolerability of once-daily extended release quetiapine fumarate (quetiapine XR) monotherapy in generalized anxiety disorder (GAD). This was a 8 week randomized, 2-week follow-up, double-bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cc77595855aa1febf0621c04a51fd5
https://doi.org/10.1097/yic.0b013e32834d9f49
https://doi.org/10.1097/yic.0b013e32834d9f49
Publikováno v:
Journal of clinical pharmacology. 56(8)
Naloxegol, a peripherally acting μ-opioid receptor antagonist, was recently approved in the United States for the treatment of opioid-induced constipation. This study evaluated the effects of CYP3A inhibition and induction on the pharmacokinetics, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ed1250ac4446882237ca08c9fa80d3
https://pubmed.ncbi.nlm.nih.gov/26678015
https://pubmed.ncbi.nlm.nih.gov/26678015
Autor:
Arifulla, Khan, Sarah, Atkinson, Irina, Mezhebovsky, Fahua, She, Todd, Leathers, Sanjeev, Pathak
Publikováno v:
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. 26(1)
For many patients with generalized anxiety disorder (GAD), first-line treatment does not lead to remission. This study investigated the efficacy and tolerability of adjunctive extended-release quetiapine fumarate (quetiapine XR) in patients with GAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3fd4196b88a87c9ba619a7c80df9aa96
https://pubmed.ncbi.nlm.nih.gov/24660224
https://pubmed.ncbi.nlm.nih.gov/24660224
Publikováno v:
Journal of clinical pharmacology. 54(12)
Naloxegol is a peripherally acting µ-opioid receptor antagonist (PAMORA) in development for the treatment of opioid-induced constipation (OIC). The pharmacokinetics of a single oral 25-mg dose of naloxegol in plasma was assessed in patients with mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0507d4c7700745c2d78ec1ac03dada49
https://pubmed.ncbi.nlm.nih.gov/24945932
https://pubmed.ncbi.nlm.nih.gov/24945932
Publikováno v:
International journal of geriatric psychiatry. 28(6)
The objective of the study was to evaluate once-daily extended release quetiapine fumarate (quetiapine XR) monotherapy in older patients with generalized anxiety disorder (GAD).An 11-week (9-week treatment; 2-week posttreatment), randomized, double-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8d835b391c4b90b101ce38580886705
https://pubmed.ncbi.nlm.nih.gov/23070803
https://pubmed.ncbi.nlm.nih.gov/23070803