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Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

Autor: Bruand, M., Barras, D., Mina, M., Ghisoni, E., Morotti, M., Lanitis, E., Fahr, N., Desbuisson, M., Grimm, A., Zhang, H., Chong, C., Dagher, J., Chee, S., Tsianou, T., Dorier, J., Stevenson, B.J., Iseli, C., Ronet, C., Bobisse, S., Genolet, R., Walton, J., Bassani-Sternberg, M., Kandalaft, L.E., Ren, B., McNeish, I., Swisher, E., Harari, A., Delorenzi, M., Ciriello, G., Irving, M., Rusakiewicz, S., Foukas, P.G., Martinon, F.

Publikováno v: Cell reports, vol. 36, no. 3, pp. 109412

In this study, we investigate mechanisms leading to inflammation and immunoreactivity in ovarian tumors with homologous recombination deficiency (HRD). BRCA1 loss is found to lead to transcriptional reprogramming in tumor cells and cell-intrinsic inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::3f767cff1ee27d8dc981fac2a83321be
https://serval.unil.ch/notice/serval:BIB_745449157CA6

27MO Integrated digital pathology and single-cell analysis identify the spatial and temporal evolution of immune cells networks in epithelial ovarian cancer

Autor: Ghisoni, E., Benedetti, F., Cunnea, P., Fahr, N., Gulhan, D.C., Minasyan, A., Desbuisson, M., Grimm, A., Barras, D., Dagher, J., Fortis, E., Rusakiewicz, S., Tissot, S., Mastroyannis, S.A., Swisher, E., Kandalaft, L., Tanyi, J., Fotopoulou, C., Coukos, G., Dangaj, D.

Publikováno v: In Annals of Oncology June 2022 33 Supplement 5:S395-S395

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Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING.

Autor: Bruand M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Barras D; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Mina M; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Department of Computational Biology, UNIL, Lausanne, Switzerland., Ghisoni E; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Morotti M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Lanitis E; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Fahr N; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Desbuisson M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Grimm A; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Zhang H; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China., Chong C; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Dagher J; Institute of Pathology, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Chee S; Ludwig Institute for Cancer Research and University of California, La Jolla, CA, USA., Tsianou T; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Dorier J; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Bioinformatics Competence Center, University of Lausanne, Lausanne, Switzerland., Stevenson BJ; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Iseli C; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ronet C; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Bobisse S; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Genolet R; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Walton J; Department of Surgery & Cancer, Ovarian Cancer Action Research Centre, Hammersmith Hospital, Imperial College London, London, UK., Bassani-Sternberg M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Kandalaft LE; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Ren B; Ludwig Institute for Cancer Research and University of California, La Jolla, CA, USA., McNeish I; Department of Surgery & Cancer, Ovarian Cancer Action Research Centre, Hammersmith Hospital, Imperial College London, London, UK., Swisher E; Department of Oncology, Washington University, Seattle, WA, USA., Harari A; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Delorenzi M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ciriello G; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Department of Computational Biology, UNIL, Lausanne, Switzerland., Irving M; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Rusakiewicz S; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland., Foukas PG; 2nd Department of Pathology, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece., Martinon F; Department of Biochemistry, UNIL, Lausanne, Switzerland., Dangaj Laniti D; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland. Electronic address: denarda.dangaj@chuv.ch., Coukos G; Ludwig Institute for Cancer Research, University Hospital of Lausanne (CHUV), Lausanne, Switzerland. Electronic address: george.coukos@chuv.ch.

Publikováno v: Cell reports [Cell Rep] 2021 Jul 20; Vol. 36 (3), pp. 109412.