In Vivo Trafficking of the Anticancer Drug Tris(8-Quinolinolato) Gallium (III) (KP46) by Gallium-68/67 PET/SPECT Imaging

Autor: Afnan M. F. Darwesh, Cinzia Imberti, Joanna J. Bartnicka, Fahad Al-Salemee, Julia E. Blower, Alex Rigby, Jayanta Bordoloi, Alex Griffiths, Michelle T. Ma, Philip J. Blower

Publikováno v: Molecules, Vol 28, Iss 20, p 7217 (2023)

KP46 (tris(hydroxyquinolinato)gallium(III)) is an experimental, orally administered anticancer drug. Its absorption, delivery to tumours, and mode of action are poorly understood. We aimed to gain insight into these issues using gallium-67 and galliu

Externí odkaz: https://doaj.org/article/781d2e5334fb4f919bb9b6a45b0024d7

Data from HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models

Autor: Tony Ng, Hing Y. Leung, Simon Chowdhury, Bart Vanhaesebroeck, Greg Mullen, László Orfi, Bálint Szokol, Richard Beatson, Kenrick Ng, Paul R. Barber, Fahad Al-Salemee, James Monypenny, Gregory Weitsman, Myria Galazi, Valentí Gómez

Prostate cancer remains a major cause of male mortality. Genetic alteration of the PI3K/AKT/mTOR pathway is one of the key events in tumor development and progression in prostate cancer, with inactivation of the PTEN tumor suppressor being very commo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62aed7b428da55981a2be8b99701f2cf
https://doi.org/10.1158/1535-7163.c.6543306

PET Imaging of Small Extracellular Vesicles

Autor: Azalea A, Khan, Francis, Man, Farid N, Faruqu, Jana, Kim, Fahad, Al-Salemee, Amaia, Carrascal-Miniño, Alessia, Volpe, Revadee, Liam-Or, Paul, Simpson, Gilbert O, Fruhwirth, Khuloud T, Al-Jamal, Rafael, T M de Rosales

Publikováno v: Bioconjugate chemistry. 33(3)

Exosomes or small extracellular vesicles (sEVs) are increasingly gaining attention for their potential as drug delivery systems and biomarkers of disease. Therefore, it is important to understand their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c2962ddeff435eae43ee8ee2ba286cc
https://pubmed.ncbi.nlm.nih.gov/35224973

One-step, kit-based radiopharmaceuticals for molecular SPECT imaging:a versatile diphosphine chelator for 99mTc radiolabelling of peptides

Autor: Michelle T. Ma, Ingebjørg N Hungnes, Fiona Clarke, Paul G. Pringle, Thomas R. Eykyn, Philip J. Blower, Fahad Al-Salemee, Samantha Y.A. Terry, R. Andrew Atkinson, Peter J. Gawne

Publikováno v: Hungnes, I N, Al-Salemee, F, Gawne, P J, Eykyn, T, Atkinson, R A, Terry, S Y A, Clarke, F, Blower, P J, Pringle, P G & Ma, M T 2021, ' One-step, kit-based radiopharmaceuticals for molecular SPECT imaging : a versatile diphosphine chelator for 99mTc radiolabelling of peptides ', Dalton Transactions, vol. 50, no. 44, pp. 16156-16165 . https://doi.org/10.1039/d1dt03177e
Dalton Transactions
Dalton Transactions, Royal Society of Chemistry, 2021, 50 (44), pp.16156-16165. ⟨10.1039/d1dt03177e⟩
Hungnes, I, Al Salemee, F, Gawne, P, Eykyn, T R, Atkinson, A, Terry, S, Clarke, F, Blower, P J, Pringle, P G & Ma, M 2021, ' One-step, kit-based radiopharmaceuticals for molecular SPECT imaging: a versatile diphosphine chelator for 99m Tc radiolabelling of peptides ', Dalton Transactions, vol. 50, no. 44, pp. 16156-16165 . https://doi.org/10.1039/D1DT03177E

Radiotracers labelled with technetium-99m (99mTc) enable accessible diagnostic imaging of disease, provided that radiotracer preparation is simple. Whilst 99mTc radiopharmaceuticals for imaging perfusion are routinely prepared from kits, and regularl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9215b53701872aac69e2b7a2f051abaa
https://hdl.handle.net/1983/fb96ed35-28e8-45e8-8768-7b359c87aac6

The Hantzsch reaction for nitrogen-13 PET: preparation of [13N]nifedipine and derivatives

Autor: Michelle T. Ma, Antony D. Gee, Fahad Al-Salemee, Julia E. Blower

Publikováno v: Blower, J, Ma, M, Al-Salemee, F & Gee, T 2021, ' The Hantzsch reaction for nitrogen-13 PET: preparation of [ 13 N]nifedipine and derivatives ', Chemical communications (Cambridge, England), vol. 57, no. 40, pp. 4962-4965 . https://doi.org/10.1039/d1cc00495f

Nitrogen-13 is an attractive but under-used PET radionuclide for labelling molecules of biological and pharmaceutical interest, complementing other PET radionuclides. Its short half-life (t1/2 = 9.97 min) imposes synthetic challenges, but we have exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42177d96ee0d1b5422f5c392a58ce519
https://kclpure.kcl.ac.uk/ws/files/151199985/ChemComm_Nifedipine_March_2021_corrections_FINAL_4pg.pdf