Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities

Autor: Deyhim Atarod, Fatemeh Mamashli, Atiyeh Ghasemi, Faezeh Moosavi-Movahedi, Mitra Pirhaghi, Hadi Nedaei, Vladimir Muronetz, Thomas Haertlé, Jörg Tatzelt, Gholamhossein Riazi, Ali Akbar Saboury

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract α-Synuclein (α-Syn) aggregates are key components of intracellular inclusion bodies characteristic of Parkinson’s disease (PD) and other synucleinopathies. Metal ions have been considered as the important etiological factors in PD since

Externí odkaz: https://doaj.org/article/41350441dded4e119e8788cf12fedb76

Sortase-mediated immobilization of Candida antarctica lipase B (CalB) on graphene oxide; comparison with chemical approach

Autor: Faezeh Moosavi, Faezeh Ahrari, Gholamreza Ahmadian, Mehdi Mohammadi

Publikováno v: Biotechnology Reports, Vol 34, Iss , Pp e00733- (2022)

In this study, Candida antarctica lipase B (CalB) was covalently immobilized on the surface of graphene oxide (GO) nanoparticles by sortase-mediated immobilization as well as a chemical attachment approach. Sortase is a transpeptidase that provides o

Externí odkaz: https://doaj.org/article/ed5a4ebc55844bbd8589a0b40e4f9a21

Structural and functional studies of D109A human αB-crystallin contributing to the development of cataract and cardiomyopathy diseases.

Autor: Mahtab Hafizi, Natalia A Chebotareva, Maryam Ghahramani, Faezeh Moosavi-Movahedi, Seyed Hossein Khaleghinejad, Boris I Kurganov, Ali Akbar Moosavi-Movahedi, Reza Yousefi

Publikováno v: PLoS ONE, Vol 16, Iss 11, p e0260306 (2021)

αB-crystallin (heat shock protein β5/HSPB5) is a member of the family of small heat shock proteins that is expressed in various organs of the human body including eye lenses and muscles. Therefore, mutations in the gene of this protein (CRYAB) migh

Externí odkaz: https://doaj.org/article/2a1fa7cc4dec48de81ecdd8034460955

The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production:Highlighting its antibiotic activity

Autor: Mitra, Pirhaghi, Zahra, Najarzadeh, Faezeh, Moosavi-Movahedi, Mahshid, Shafizadeh, Fatemeh, Mamashli, Deyhim, Atarod, Atiyeh, Ghasemi, Dina, Morshedi, Ali Akbar, Meratan, Daniel E, Otzen, Ali Akbar, Saboury

Publikováno v: Pirhaghi, M, Najarzadeh, Z, Moosavi-Movahedi, F, Shafizadeh, M, Mamashli, F, Atarod, D, Ghasemi, A, Morshedi, D, Meratan, A A, Otzen, D E & Saboury, A A 2023, ' The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production : Highlighting its antibiotic activity ', Biochimica et Biophysica Acta-Proteins and Proteomics, vol. 1871, no. 2, 140883 . https://doi.org/10.1016/j.bbapap.2022.140883

Multidrug resistance of bacteria and persistent infections related to biofilms, as well as the low availability of new antibacterial drugs, make it urgent to develop new antibiotics. Here, we evaluate the antibacterial and anti-biofilm properties of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c783bae4f81abd4bae5ec230b48fbfc
https://pure.au.dk/portal/da/publications/the-antiplatelet-drug-ticlopidine-inhibits-fapc-fibrillation-and-biofilm-production(73eeea64-02c1-4f5a-b527-d61f3565bb38).html

Inhibiting mTTR Aggregation/Fibrillation by a Chaperone-like Hydrophobic Amino Acid-Conjugated SPION

Autor: Payam Arghavani, Alireza Badiei, Seyyed Abolghasem Ghadami, Mehran Habibi-Rezaei, Faezeh Moosavi-Movahedi, Ladan Delphi, Ali Akbar Moosavi-Movahedi

Publikováno v: The journal of physical chemistry. B. 126(8)

Transthyretin (TTR) aggregation via misfolding of a mutant or wild-type protein leads to systemic or partial amyloidosis (ATTR). Here, we utilized variable biophysical assays to characterize two distinct aggregation pathways for mTTR (a synthesized m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49852397a7e45514035d55ed9b9a50f0
https://pubmed.ncbi.nlm.nih.gov/35090112