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Why Does Doxycycline Pose a Relatively Low Risk for Promotion of Clostridioides difficile Infection?
Autor:
Dongyan Xu, Thriveen Mana, Jennifer Cadnum, Abhishek Deshpande, Faezeh Afsari, Naseer Sangwan, Curtis Donskey
Publikováno v:
Pathogens and Immunity, Vol 7, Iss 1 (2022)
Background: Clinical studies suggest that doxycycline poses a low risk for promotion of Clostridioides difficileinfection, but the microbiologic explanation for this finding is unclear. Methods: Mice treated with oral doxycycline, oral azithromycin,
Externí odkaz:
https://doaj.org/article/8355bf1d63e64020ae44bea788496e2a
Autor:
Faezeh Afsari, Thomas M. McIntyre
Publikováno v:
The Journal of Immunology. 210:504-514
Gliomas expressing mutant isocitrate dehydrogenases excessively synthesize d-2-hydroxyglutarate (D2HG), suppressing immune surveillance. A portion of this D2HG is released from these tumor cells, but the way environmental D2HG inhibits lymphocyte fun