Výsledky vyhledávání

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

SONOGRAPHIC EVALUATION OF THE HEART, LUNG AND DIAPHRAGM DURING WEANING FROM MECHANICALLY VENTILATED CRITICALLY ILL PATIENTS

Autor: Fady N. Guirguis, Adel Mohamad Alansary, Adel A. Habib, Nahed E. Youssef

Publikováno v: Ain Shams Medical Journal. 71:1009-1018

Background: Failure of weaning is a commonly encountered problem that faces intensivists, unfortunately this is a multifactorial condition and includes multiple interplays between cardiac and pulmonary functions. Timing is critical when determining i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50ed7509d8a4f985ffd76691e220d361
https://doi.org/10.21608/asmj.2020.148959

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate

Autor: William Bret Church, Vimal Kapoor, Mark D. Gorrell, Joohong Park, Noeris K. Salam, Naveed A. Nadvi, Fady N. Akladios, Charles A. Collyer

Publikováno v: Protein Science. 26:727-736

In this study we report two high-resolution structures of the pyridoxal 5' phosphate (PLP)-dependent enzyme kynurenine aminotransferase-I (KAT-I). One is the native structure with the cofactor in the PLP form bound to Lys247 with the highest resoluti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24ab8eb2e0885e0679d7b7998a21d1cf
https://doi.org/10.1002/pro.3119

Zobrazit plný text záznamu

A study of the allosteric inhibition of HCV RNA-dependent RNA polymerase and implementing virtual screening for the selection of promising dual-site inhibitors with low resistance potential

Autor: Andrew Samy AbdelMalak, Fady N. Baselious, Nasser S.M. Ismail, Heba S.A. El-Zahabi, Peter Sabry, Fady Hanna

Publikováno v: Journal of Receptors and Signal Transduction. 37:341-354

Structure-based pharmacophores were generated and validated using the bioactive conformations of different co-crystallized enzyme-inhibitor complexes for allosteric palm-1 and thumb-2 inhibitors of NS5B. Two pharmacophore models were obtained, one fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8feb39cff3adc3fbb20930fc94ff1e
https://doi.org/10.1080/10799893.2016.1248293

Zobrazit plný text záznamu

Increased generation of intracellular reactive oxygen species initiates selective cytotoxicity against the MCF-7 cell line resultant from redox active combination therapy using copper–thiosemicarbazone complexes

Autor: Fady N. Akladios, Scott D. Andrew, Christopher J. Parkinson

Publikováno v: JBIC Journal of Biological Inorganic Chemistry. 21:407-419

The combination of cytotoxic copper-thiosemicarbazone complexes with phenoxazines results in an up to 50-fold enhancement in the cytotoxic potential of the thiosemicarbazone against the MCF-7 human breast adenocarcinoma cell line over the effect attr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929718ad2e79efd779736bfda50857cc
https://doi.org/10.1007/s00775-016-1350-2

Zobrazit plný text záznamu

Rational design, synthesis and 2D-QSAR studies of antiproliferative tropane-based compounds

Autor: Nasser S.M. Ismail, Riham F. George, May A. El-Manawaty, Rabah A. T. Serya, ElSayed M. Shalaby, Fady N. Baselious, Adel S. Girgis

Publikováno v: RSC Advances. 6:101911-101923

3,4-Diaryl-11-methyl-7-[(aryl)methylidene]-4,5,11-triazatricyclo[6.2.1.0*2,6*]undec-5-enes 14a–s were synthesized through reaction of 2,4-bis[(aryl)methylidene]-8-methyl-8-azabicyclo[3.2.1]octan-3-ones 12a–f with aryl hydrazines in the presence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8948c8015f12a2471e671018ecc3701a
https://doi.org/10.1039/c6ra21486j

Zobrazit plný text záznamu

Improved cytotoxicity of pyridyl-substituted thiosemicarbazones against MCF-7 when used as metal ionophores

Autor: Scott D. Andrew, Fady N. Akladios, Christopher J. Parkinson

Publikováno v: BioMetals. 29:157-170

Zinc is the second most abundant transition metal in the human body, between 3 and 10% of human genes encoding for zinc binding proteins. We have investigated the interplay of reactive oxygen species and zinc homeostasis on the cytotoxicity of the th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8ddd1c25af20503153f0ab40c5f112
https://doi.org/10.1007/s10534-015-9905-1

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání