Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Fadi Towfic"'
Autor:
Matthew E. Stokes, Kerstin Wenzl, C. Chris Huang, María Ortiz, Chih-Chao Hsu, Matthew J. Maurer, Nicholas Stong, Yumi Nakayama, Lei Wu, Hsiling Chiu, Ann Polonskaia, Samuel A. Danziger, Fadi Towfic, Joel Parker, Rebecca L. King, Brian K. Link, Susan L. Slager, Vivekananda Sarangi, Yan W. Asmann, Joseph P. Novak, Akshay Sudhindra, Stephen M. Ansell, Thomas M. Habermann, Patrick R. Hagner, Grzegorz S. Nowakowski, James R. Cerhan, Anne J. Novak, Anita K. Gandhi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immunochemotherapy has been the mainstay of treatment for newly diagnosed diffuse large B-cell lymphoma (ndDLBCL) yet is inadequate for many patients. In this work, we perform unsupervised clustering on transcriptomic features from a large c
Externí odkaz:
https://doaj.org/article/4dae5fe5634e4259b6d610f0ad207e8d
Autor:
María Ortiz-Estévez, Fadi Towfic, Erin Flynt, Nicholas Stong, In Sock Jang, Kai Wang, Matthew W. B. Trotter, Anjan Thakurta
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background Despite significant therapeutic advances in improving lives of multiple myeloma (MM) patients, it remains mostly incurable, with patients ultimately becoming refractory to therapies. MM is a genetically heterogeneous disease and t
Externí odkaz:
https://doaj.org/article/e346ccc8aa5a40cdb54209d390d619d8
Autor:
Kubra Karagoz, Matthew Stokes, María Ortiz-Estévez, Fadi Towfic, Erin Flynt, Sarah Gooding, William Pierceall, Anjan Thakurta
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Immunomodulatory drugs (IMiDs), including lenalidomide and pomalidomide, are used in the routine treatment for multiple myeloma (MM) patients. Cereblon (CRBN) is the direct molecular target of IMiDs. While CRBN is not an essential gene for MM cell pr
Externí odkaz:
https://doaj.org/article/6bb06294542945bea1056ef1be9a9303
Autor:
David Nelson, Christos Hatzis, Jimena Trillo-Tinoco, Evisa Gjini, Ana Lako, Michaela Bowden, Andrew Browne, Ryan Powles, Tai Wang, Christine Tauras, Ruben Ferrer-Luna, Zoe Bleicher, Timothy Consedine, Chensheng Zhou, Evan Kelemen, Anne Lewin, Catherine King, Sumit Bhattacharya, Harris Bell-Temin, Ashok Dongre, Kenzie Macisaac, Fadi Towfic, Benjamin Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/5ffa5e3941684c79b3352cf245882bc4
Autor:
Colin J. Ross, Fadi Towfic, Jyoti Shankar, Daphna Laifenfeld, Mathis Thoma, Matthew Davis, Brian Weiner, Rebecca Kusko, Ben Zeskind, Volker Knappertz, Iris Grossman, Michael R. Hayden
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-15 (2017)
Abstract Background Copaxone is an efficacious and safe therapy that has demonstrated clinical benefit for over two decades in patients with relapsing forms of multiple sclerosis (MS). On an individual level, patients show variability in their respon
Externí odkaz:
https://doaj.org/article/c1be08a547904e9a8226e7d2e3152de0
Publikováno v:
Cells, Vol 9, Iss 2, p 287 (2020)
Multiple myeloma (MM) is the second most common hematological cancer and is characterized by genetic features including translocations, chromosomal copy number aberrations, and mutations in key oncogene and tumor suppressor genes. Dysregulation of th
Externí odkaz:
https://doaj.org/article/cc230b83ff66479ab03b3bc132e255da
Publikováno v:
Bioinformatics and Biology Insights, Vol 2012, Iss 6, Pp 235-246 (2012)
Externí odkaz:
https://doaj.org/article/71604dcd0b504b8691305875ae57f253
Autor:
Fadi Towfic, Jason M Funt, Kevin D Fowler, Shlomo Bakshi, Eran Blaugrund, Maxim N Artyomov, Michael R Hayden, David Ladkani, Rivka Schwartz, Benjamin Zeskind
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83757 (2014)
For decades, policies regarding generic medicines have sought to provide patients with economical access to safe and effective drugs, while encouraging the development of new therapies. This balance is becoming more challenging for physicians and reg
Externí odkaz:
https://doaj.org/article/d9ac4720e37d456aa3e0668f876f8ecc
Correction: Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse.
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/c55fe0ded5444de48267c17e7357a977
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59701 (2013)
Our ability to successfully intervene in disease processes is dependent on definitive diagnosis. In the case of autoimmune disease, this is particularly challenging because progression of disease is lengthy and multifactorial. Here we show the first
Externí odkaz:
https://doaj.org/article/58be6590cb4549daadc8d19eb1753cb6