Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Fadi J. Najm"'
Autor:
Fadi J. Najm, Peter DeWeirdt, Molly M. Moore, Samantha M. Bevill, Chadi A. El Farran, Kevin A. Macias, Mudra Hegde, Amanda L. Waterbury, Brian B. Liau, Peter van Galen, John G. Doench, Bradley E. Bernstein
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia cells to discover compensatory non-lethal or synergistic lethal combinations wit
Externí odkaz:
https://doaj.org/article/12d36487c2074c269464c36c6c8a08b8
Autor:
Zeyu Chen, Nauman Javed, Molly Moore, Jingyi Wu, Michael Vinyard, Luca Pinello, Fadi J. Najm, Bradley E. Bernstein
SummaryAlthough vast numbers of putative gene regulatory elements have been cataloged, the sequence motifs and individual bases that underlie their functions remain largely unknown. Here we combine epigenetic perturbations, base editing, and deep lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3df483759a836c661bfa4b4bf4465ceb
https://doi.org/10.1101/2022.10.05.511030
https://doi.org/10.1101/2022.10.05.511030
Autor:
Samantha M. Bevill, Salvador Casaní-Galdón, Chadi A. El Farran, Eli G. Cytrynbaum, Kevin A. Macias, Sylvie E. Oldeman, Kayla J. Oliveira, Molly M. Moore, Esmat Hegazi, Carmen Adriaens, Fadi J. Najm, George D. Demetri, Sonia Cohen, John T. Mullen, Nicolò Riggi, Sarah E. Johnstone, Bradley E. Bernstein
Publikováno v:
Cell Genomics. :100321
Autor:
Sofia Battaglia, Kevin Dong, Jingyi Wu, Zeyu Chen, Fadi J. Najm, Yuanyuan Zhang, Molly M. Moore, Vivian Hecht, Noam Shoresh, Bradley E. Bernstein
Publikováno v:
Nature genetics. 54(10)
Epigenomic maps identify gene regulatory elements by their chromatin state. However, prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate the interdependence of elements in a locus or capture single-molecule dynam
Autor:
Zeyu Chen, Nauman Javed, Molly Moore, Jingyi Wu, Gary Sun, Michael Vinyard, Alejandro Collins, Luca Pinello, Fadi J. Najm, Bradley E. Bernstein
Publikováno v:
Cell Genomics. :100318
Autor:
Fadi J. Najm, Peter van Galen
Publikováno v:
Blood. 139(6)
Autor:
Paul J. Tesar, Robert T. Karl, Drew J. Adams, Tyler E. Miller, Ranjan Dutta, Gursimran Dhillon, Olivia Corradin, An T. Hoang, Parker A. Hall, Bruna R. Lima, Sagar Nisraiyya, Alexey Kozlenkov, Mayur Madhavan, Anna M. Barbeau, Christina Volsko, Cynthia F. Bartels, Peter C. Scacheri, Stella Dracheva, Fadi J. Najm, Kathryn E.A. Hazel, Daniel C. Factor, Zachary S. Nevin
Publikováno v:
SSRN Electronic Journal.
Multiple sclerosis (MS) is an autoimmune disease characterized by attack on oligodendrocytes within the central nervous system (CNS). Despite widespread use of immunomodulatory therapies, patients face progressive disability due to failure of myelin
Autor:
Eric C. Freundt, Anthony J Martorell, Padmanabhan Mahadevan, Paul J. Tesar, Bayleigh Benner, Fadi J. Najm
Publikováno v:
Journal of NeuroVirology. 22:336-348
Theiler's murine encephalomyelitis virus (TMEV) infects the central nervous system of mice and causes a demyelinating disease that is a model for multiple sclerosis. During the chronic phase of the disease, TMEV persists in oligodendrocytes and macro
Autor:
Gursimran Dhillon, Cynthia F. Bartels, Ranjan Dutta, Peter C. Scacheri, Stella Dracheva, Lucille R. Hu, Kevin C. Allan, Fadi J. Najm, Michael D. Gallagher, Anna M. Barbeau, Christina Volsko, Mayur Madhavan, Parker A. Hall, Bruna R. Lima, Kathryn E.A. Hazel, Daniel C. Factor, William Phu, Alexandra G. Sibert, Yanwei Song, Robert T. Karl, Olivia Corradin, An T. Hoang, Drew J. Adams, Sagar Nisraiyya, Alexey Kozlenkov, Zachary S. Nevin, Tyler E. Miller, Paul J. Tesar
Publikováno v:
Cell
Summary Multiple sclerosis (MS) is an autoimmune disease characterized by attack on oligodendrocytes within the central nervous system (CNS). Despite widespread use of immunomodulatory therapies, patients may still face progressive disability because
Publikováno v:
Neuromethods ISBN: 9781493970223
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26d334aacbfe2606dbd3fba84b6faa88
https://doi.org/10.1007/978-1-4939-7024-7_5
https://doi.org/10.1007/978-1-4939-7024-7_5