Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Fadi Ghantous"'
Autor:
Moustafa T. Mabrouk, Asmaa A. Zidan, Nihal Aly, Mostafa T. Mohammed, Fadi Ghantous, Michael S. Seaman, Jonathan F. Lovell, Mahmoud L. Nasr
Publikováno v:
Vaccines, Vol 11, Iss 11, p 1655 (2023)
The emergence of vaccine-evading SARS-CoV-2 variants urges the need for vaccines that elicit broadly neutralizing antibodies (bnAbs). Here, we assess covalently circularized nanodiscs decorated with recombinant SARS-CoV-2 spike glycoproteins from sev
Externí odkaz:
https://doaj.org/article/979cf9242ae84e49af152034eb636e87
Autor:
Michael S. Seaman, Mark J. Siedner, Julie Boucau, Christy L. Lavine, Fadi Ghantous, May Y. Liew, Josh I. Mathews, Arshdeep Singh, Caitlin Marino, James Regan, Rockib Uddin, Manish C. Choudhary, James P. Flynn, Geoffrey Chen, Ashley M. Stuckwisch, Taryn Lipiner, Autumn Kittilson, Meghan Melberg, Rebecca F. Gilbert, Zahra Reynolds, Surabhi L. Iyer, Grace C. Chamberlin, Tammy D. Vyas, Jatin M. Vyas, Marcia B. Goldberg, Jeremy Luban, Jonathan Z. Li, Amy K. Barczak, Jacob E. Lemieux
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Protective immunity against SARS-CoV-2 infection after COVID-19 vaccination may differ by variant. We enrolled vaccinated (n = 39) and unvaccinated (n = 11) individuals with acute, symptomatic SARS-CoV-2 Delta or Omicron infection and performed SARS-
Externí odkaz:
https://doaj.org/article/f38fc7bc66254b8ba43336ada4cb99c2
Autor:
Alessandro Piai, Qingshan Fu, Yongfei Cai, Fadi Ghantous, Tianshu Xiao, Md Munan Shaik, Hanqin Peng, Sophia Rits-Volloch, Wen Chen, Michael S. Seaman, Bing Chen, James J. Chou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
HIV-1 envelope glycoprotein (Env) mediates the fusion of viral and target cell membranes and is a major target for HIV vaccine development. Here, the authors determine the NMR structure of a bicelle incorporated Env segment comprising the transmembra
Externí odkaz:
https://doaj.org/article/e13057d2254f431aa52b8fc7024ffbdf
Autor:
Basak Eraslan, Eric Brown, Maura Benson, Liat Amir-Zilberstein, Sung-Moo Park, Betsabeh Tusi, Vladislav Pokatayev, Cody Hecht, Novalia Pishesha, Devan Phillips, Andy Kim, Shuting Zhang, Anthony Gaca, Fadi Ghantous, Toni Delorey, Jonathan Livny, Lindsey Baden, Orit Rozenblatt-Rosen, Daniel Graham, Aviv Regev, Michael Seaman, Ann Woolley, Lisa Cosimi, Deborah Hung, Jacques Deguine, Ramnik Xavier
Publikováno v:
Research square.
SARS-CoV-2 infection leads to a broad range of outcomes and immune responses, with the development of neutralizing antibodies generally correlated with protection against reinfection. Here, we have characterized both neutralizing activity and T cell
Autor:
Michael S. Seaman, Mark J. Siedner, Julie Boucau, Christy L. Lavine, Fadi Ghantous, May Y. Liew, Josh Mathews, Arshdeep Singh, Caitlin Marino, James Regan, Rockib Uddin, Manish C. Choudhary, James P. Flynn, Geoffrey Chen, Ashley M. Stuckwisch, Taryn Lipiner, Autumn Kittilson, Meghan Melberg, Rebecca F. Gilbert, Zahra Reynolds, Surabhi L. Iyer, Grace C. Chamberlin, Tammy D. Vyas, Jatin M. Vyas, Marcia B. Goldberg, Jeremy Luban, Jonathan Z. Li, Amy K. Barczak, Jacob E. Lemieux
Publikováno v:
medRxiv : the preprint server for health sciences.
There is increasing evidence that the risk of SARS-CoV-2 infection among vaccinated individuals is variant-specific, suggesting that protective immunity against SARS-CoV-2 may differ by variant. We enrolled vaccinated (n = 39) and unvaccinated (n = 1
Autor:
Lisa A. Cosimi, Betsabeh Khoramian Tusi, Yiska Weisblum, Kathryn E. Huey-Tubman, Andrew Hudak, Alexander A. Cohen, Orit Rozenblatt-Rosen, Lindsey R. Baden, Aviv Regev, Kara Rzasa, Frauke Muecksch, Michael S. Seaman, Xiebin Gu, Christopher O. Barnes, Jennifer R. Keeffe, Ann E. Woolley, Paul D. Bieniasz, Michael A Durney, Priyanthi N. P. Gnanapragasam, Toni Delorey, Anthony P. West, Pamela J. Bjorkman, Sung-Moo Park, Devan Phillips, Takuya Tada, Fadi Ghantous, Johannes Scheid, Deborah T. Hung, Shuting Zhang, Nathaniel R. Landau, Ramnik J. Xavier, Jacques Deguine, Daniel B. Graham, Basak Eraslan, Eric M. Brown, Theodora Hatziioanno
Publikováno v:
Cell
Monoclonal antibodies (mAbs) are a focus in vaccine and therapeutic design to counteract SARS-CoV-2 and its variants. Here, we combined B cell sorting with single-cell VDJ and RNA-seq and mAb structures to characterize B cell responses against SARS-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1620e23fa39fd9c246a23789249c7917
https://resolver.caltech.edu/CaltechAUTHORS:20210429-090704273
https://resolver.caltech.edu/CaltechAUTHORS:20210429-090704273
Autor:
Hanqin Peng, Qingshan Fu, James J. Chou, Sophia Rits-Volloch, Munan Shaik, Michael S. Seaman, Stephen C. Harrison, Bing Chen, Fadi Ghantous, Yongfei Cai, Zhijun Liu, Alessandro Piai
The membrane-proximal external region (MPER) of the HIV-1 envelope glycoprotein (Env) bears epitopes of broadly neutralizing antibodies (bnAbs) from infected individuals; it is thus a potential vaccine target. We report an NMR structure of the MPER a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca62f767d7175a75f70a009fc16d1d0
https://europepmc.org/articles/PMC6156635/
https://europepmc.org/articles/PMC6156635/
Autor:
Lindsey Gillis, Fadi Ghantous, Bronwyn M. Gunn, Christine A. Bricault, James M. Kovacs, James R. Perry, Michael S. Seaman, Nicole A. Doria-Rose, Kathryn E. Stephenson, George H. Neubauer, Bing Chen, Dan H. Barouch, Joseph P. Nkolola, John R. Mascola, Krisha McKee, Alexander Badamchi-Zadeh, Galit Alter, Jennifer L. Shields, Julia Jennings
Publikováno v:
Journal of Virology
A vaccination regimen capable of eliciting potent and broadly neutralizing antibodies (bNAbs) remains an unachieved goal of the HIV-1 vaccine field. Here, we report the immunogenicity of longitudinal prime/boost vaccination regimens with a panel of H
Autor:
Christine A. Bricault, Karina Yusim, Michael S. Seaman, Hyejin Yoon, James Theiler, Elena E. Giorgi, Kshitij Wagh, Maxwell Theiler, Peter Hraber, Jennifer P. Macke, Edward F. Kreider, Gerald H. Learn, Beatrice H. Hahn, Johannes F. Scheid, James M. Kovacs, Jennifer L. Shields, Christy L. Lavine, Fadi Ghantous, Michael Rist, Madeleine G. Bayne, George H. Neubauer, Katherine McMahan, Hanqin Peng, Coraline Chéneau, Jennifer J. Jones, Jie Zeng, Christina Ochsenbauer, Joseph P. Nkolola, Kathryn E. Stephenson, Bing Chen, S. Gnanakaran, Mattia Bonsignori, LaTonya D. Williams, Barton F. Haynes, Nicole Doria-Rose, John R. Mascola, David C. Montefiori, Dan H. Barouch, Bette Korber
Publikováno v:
Cell Host & Microbe
Summary Eliciting HIV-1-specific broadly neutralizing antibodies (bNAbs) remains a challenge for vaccine development, and the potential of passively delivered bNAbs for prophylaxis and therapeutics is being explored. We used neutralization data from
Autor:
Jia Chen, Bing Chen, Jyoti Dev, Heather Jiwon Ha, Donghyun Park, Michael S. Seaman, Gary Frey, Fadi Ghantous, James J. Chou, Zhijun Liu, Tobias Herrmann, Weiting Chang, Qingshan Fu
Publikováno v:
Science (New York, N.Y.). 353(6295)
Env's transmembrane domain revealed HIV-1's envelope protein (Env) spans the viral membrane and grants the virus entry into host cells. Env is also the sole protein of HIV-1 that is targeted by antibodies, making it a key target for vaccine design. D