Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Fadi G Akar"'
Autor:
Michael W. Rudokas, Margaret McKay, Zeren Toksoy, Julia N. Eisen, Markus Bögner, Lawrence H. Young, Fadi G. Akar
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Mitochondria play a central role in cellular energy metabolism, and their dysfunction is increasingly recognized as a critical factor in the pathogenesis of diabetes-related cardiac pathophysiology, including vulnerability to ischemic events
Externí odkaz:
https://doaj.org/article/b2f397b4ab4b47cc82c3cdc543d7e8d2
Autor:
Basil S Karam, Fadi G Akar
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Externí odkaz:
https://doaj.org/article/433e5675481e4dd5967868a62089e26f
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Permeability transition pore (mPTP) opening leads to mitochondrial dysfunction & cell death during oxidative stress (OS). However mPTP desensitization with cyclosporine A (CsA) has shown variable efficacy in limiting post-ischemic arrhythmias. We hyp
Externí odkaz:
https://doaj.org/article/e545dc93608646b8941ec7e424e9a489
Autor:
Chaoqin eXie, Fadi G Akar
Publikováno v:
Frontiers in Physiology, Vol 1 (2010)
Externí odkaz:
https://doaj.org/article/8459c0c7a9114b2986ac57293836904b
Autor:
Evan V. Jenkins, Dhani Dharmaprani, Madeline Schopp, Jing Xian Quah, Kathryn Tiver, Lewis Mitchell, Feng Xiong, Martin Aguilar, Kenneth Pope, Fadi G. Akar, Caroline H. Roney, Steven A. Niederer, Stanley Nattel, Martyn P. Nash, Richard H. Clayton, Anand N. Ganesan
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background and Objective: Renewal theory is a statistical approach to model the formation and destruction of phase singularities (PS), which occur at the pivots of spiral waves. A common issue arising during observation of renewal processes is an ins
Externí odkaz:
https://doaj.org/article/664837bf89df46e199ca5af997fc3930
Autor:
Valeria Novelli, Fadi G. Akar
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/d8c2e676fcf342c385134c07632dbbab
Autor:
Kevin N. Su, Yina Ma, Marine Cacheux, Zeki Ilkan, Nour Raad, Grace K. Muller, Xiaohong Wu, Nicole Guerrera, Stephanie L. Thorn, Albert J. Sinusas, Marc Foretz, Benoit Viollet, Joseph G. Akar, Fadi G. Akar, Lawrence H. Young
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Metabolic stress is an important cause of pathological atrial remodeling and atrial fibrillation. AMPK is a ubiquitous master metabolic regulator, yet its biological function in the atria is poorly understood in both health and disease. We investigat
Externí odkaz:
https://doaj.org/article/89a8b570681a43d5b439e41dbe042fb5
Autor:
Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey
Publikováno v:
Cells, Vol 11, Iss 19, p 3049 (2022)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete
Externí odkaz:
https://doaj.org/article/63890685f8b04fc6b2be5d434329bc0f
Autor:
Margaret McKay, Fadi G Akar
Publikováno v:
Cardiovascular Research. 119:333-335
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76cccc557582d2734f18baa9e4d23679
https://doi.org/10.1093/cvr/cvad033
https://doi.org/10.1093/cvr/cvad033
Autor:
Jaydev Dave, Nour Raad, Nishka Mittal, Lu Zhang, Anthony Fargnoli, Jae Gyun Oh, Maria Elisabetta Savoia, Jens Hansen, Marika Fava, Xiaoke Yin, Konstantinos Theofilatos, Delaine Ceholski, Erik Kohlbrenner, Dongtak Jeong, Lauren Wills, Mathieu Nonnenmacher, Kobra Haghighi, Kevin D Costa, Irene C Turnbull, Manuel Mayr, Chen-Leng Cai, Evangelia G Kranias, Fadi G Akar, Roger J Hajjar, Francesca Stillitano
Publikováno v:
Cardiovasc Res
Aims A mutation in the phospholamban (PLN) gene, leading to deletion of Arg14 (R14del), has been associated with malignant arrhythmias and ventricular dilation. Identifying pre-symptomatic carriers with vulnerable myocardium is crucial because arrhyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbedb98cc0fa6633afea4ced1ed20e3
https://doi.org/10.1093/cvr/cvac021
https://doi.org/10.1093/cvr/cvac021