Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Fadi G Akar"'
Autor:
Michael W. Rudokas, Margaret McKay, Zeren Toksoy, Julia N. Eisen, Markus Bögner, Lawrence H. Young, Fadi G. Akar
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Mitochondria play a central role in cellular energy metabolism, and their dysfunction is increasingly recognized as a critical factor in the pathogenesis of diabetes-related cardiac pathophysiology, including vulnerability to ischemic events
Externí odkaz:
https://doaj.org/article/b2f397b4ab4b47cc82c3cdc543d7e8d2
Autor:
Evan V. Jenkins, Dhani Dharmaprani, Madeline Schopp, Jing Xian Quah, Kathryn Tiver, Lewis Mitchell, Feng Xiong, Martin Aguilar, Kenneth Pope, Fadi G. Akar, Caroline H. Roney, Steven A. Niederer, Stanley Nattel, Martyn P. Nash, Richard H. Clayton, Anand N. Ganesan
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background and Objective: Renewal theory is a statistical approach to model the formation and destruction of phase singularities (PS), which occur at the pivots of spiral waves. A common issue arising during observation of renewal processes is an ins
Externí odkaz:
https://doaj.org/article/664837bf89df46e199ca5af997fc3930
Autor:
Valeria Novelli, Fadi G. Akar
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/d8c2e676fcf342c385134c07632dbbab
Autor:
Kevin N. Su, Yina Ma, Marine Cacheux, Zeki Ilkan, Nour Raad, Grace K. Muller, Xiaohong Wu, Nicole Guerrera, Stephanie L. Thorn, Albert J. Sinusas, Marc Foretz, Benoit Viollet, Joseph G. Akar, Fadi G. Akar, Lawrence H. Young
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Metabolic stress is an important cause of pathological atrial remodeling and atrial fibrillation. AMPK is a ubiquitous master metabolic regulator, yet its biological function in the atria is poorly understood in both health and disease. We investigat
Externí odkaz:
https://doaj.org/article/89a8b570681a43d5b439e41dbe042fb5
Autor:
Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey
Publikováno v:
Cells, Vol 11, Iss 19, p 3049 (2022)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete
Externí odkaz:
https://doaj.org/article/63890685f8b04fc6b2be5d434329bc0f
Autor:
Margaret McKay, Fadi G Akar
Publikováno v:
Cardiovascular Research. 119:333-335
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76cccc557582d2734f18baa9e4d23679
https://doi.org/10.1093/cvr/cvad033
https://doi.org/10.1093/cvr/cvad033
Publikováno v:
Cardiovascular Diabetology, Vol 16, Iss 1, Pp 1-9 (2017)
Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and A
Externí odkaz:
https://doaj.org/article/822ecdcb706b43958054f00a637746ee
Autor:
Lukas J. Motloch, MD, PhD, Kiyotake Ishikawa, MD, Chaoqin Xie, MD, Jun Hu, PhD, Jaume Aguero, MD, Kenneth M. Fish, PhD, Roger J. Hajjar, MD, Fadi G. Akar, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 3, Pp 258-269 (2017)
Summary: Although the pathophysiological significance of resistant hypertension in postâmyocardial infarction (MI) patients is established, the mechanisms by which increased afterload in that setting worsens outcome are unclear. With regard to sudde
Externí odkaz:
https://doaj.org/article/567e3ad87774479d87bf53f3def6720d
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/fc51f8e2ce5b4e439143f7b7e822b80b
Autor:
Jaydev Dave, Nour Raad, Nishka Mittal, Lu Zhang, Anthony Fargnoli, Jae Gyun Oh, Maria Elisabetta Savoia, Jens Hansen, Marika Fava, Xiaoke Yin, Konstantinos Theofilatos, Delaine Ceholski, Erik Kohlbrenner, Dongtak Jeong, Lauren Wills, Mathieu Nonnenmacher, Kobra Haghighi, Kevin D Costa, Irene C Turnbull, Manuel Mayr, Chen-Leng Cai, Evangelia G Kranias, Fadi G Akar, Roger J Hajjar, Francesca Stillitano
Publikováno v:
Cardiovasc Res
Aims A mutation in the phospholamban (PLN) gene, leading to deletion of Arg14 (R14del), has been associated with malignant arrhythmias and ventricular dilation. Identifying pre-symptomatic carriers with vulnerable myocardium is crucial because arrhyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbedb98cc0fa6633afea4ced1ed20e3
https://doi.org/10.1093/cvr/cvac021
https://doi.org/10.1093/cvr/cvac021