Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Fadi Alkayal"'
Autor:
Prashantha Hebbar, Rasheeba Nizam, Motasem Melhem, Fadi Alkayal, Naser Elkum, Sumi Elsa John, Jaakko Tuomilehto, Osama Alsmadi, Thangavel Alphonse Thanaraj
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1951-1966 (2018)
Abnormal blood lipid levels are influenced by genetic and lifestyle/dietary factors. Although many genetic variants associated with blood lipid traits have been identified in Europeans, similar data in Middle Eastern populations are limited. We perfo
Externí odkaz:
https://doaj.org/article/729e23d292af49859a4a3deab60811fb
Autor:
Maha M. Hammad, Mohamed Abu-Farha, Prashantha Hebbar, Preethi Cherian, Irina Al Khairi, Motasem Melhem, Fadi Alkayal, Osama Alsmadi, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Jehad Abubaker
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Melanocortin 4 receptor (MC4R), a notable component of the melanocortin system, regulates appetite, body weight, and energy homeostasis. Genome-wide association studies have identified several MC4R variants associated with adiposity; of these, rs1778
Externí odkaz:
https://doaj.org/article/5206f2ff0dde4ce196a880986ead9c2d
Autor:
Prashantha Hebbar, Mohamed Abu-Farha, Anwar Mohammad, Fadi Alkayal, Motasem Melhem, Jehad Abubaker, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Publikováno v:
Frontiers in Genetics, Vol 10 (2020)
Association studies have implicated single nucleotide polymorphisms (SNPs), particularly rs1421085, from the fat mass and obesity-associated (FTO) gene with body composition phenotypes, obesity, dietary intake, and physical activity in European, East
Externí odkaz:
https://doaj.org/article/06bb66d3a0a44941a2a41518290c63a1
Autor:
Massimo Mezzavilla, Sara Tomei, Fadi Alkayal, Motasem Melhem, Maisa M. Ali, Monira Al-Arouj, Abdullah Bennakhi, Osama Alsmadi, Naser Elkum
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-6 (2018)
Abstract Background Differences in the concentrations of circulating 25-hydroxyvitamin D [25(OH)D] are associated with a wide range of health outcomes; however, most studies on genetic variants that impact 25(OH)D levels have been conducted in Europe
Externí odkaz:
https://doaj.org/article/e0a684089e84442cb7ba77e2aa912599
ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals
Autor:
Muath Alanbaei, Mohamed Abu-Farha, Prashantha Hebbar, Motasem Melhem, Betty S. Chandy, Emil Anoop, Preethi Cherian, Irina Al-Khairi, Fadi Alkayal, Fahd Al-Mulla, Jehad Abubaker, Thangavel Alphonse Thanaraj
Publikováno v:
Genes, Vol 12, Iss 5, p 755 (2021)
ANGPTL3 is an important regulator of lipid metabolism. Its inhibition in people with hypercholesteremia reduces plasma lipid levels dramatically. Genome-wide association studies have associated ANGPTL3 variants with lipid traits. Irisin, an exercise-
Externí odkaz:
https://doaj.org/article/aa649eaf95ba4bfab06050125a2600eb
Autor:
Ghazi Alghanim, Mohamed G. Qaddoumi, Nouf Alhasawi, Preethi Cherian, Irina Al-Khairi, Rasheeba Nizam, Fadi Alkayal, Muath Alanbaei, Jaakko Tuomilehto, Jehad Abubaker, Mohamed Abu-Farha, Fahd Al-Mulla
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Objective: The family of angiopoietin-like proteins (ANGPTLs) is composed of eight ANGPTLs members that are involved in regulating various metabolic processes and have been implicated in type 2 diabetes (T2D) and obesity. ANGPTL5 is an understudied m
Externí odkaz:
https://doaj.org/article/7c330540961442acaa97d452428a8581
Autor:
Naser Elkum, Fadi Alkayal, Fiona Noronha, Maisa M Ali, Motasem Melhem, Monira Al-Arouj, Abdullah Bennakhi, Kazem Behbehani, Osama Alsmadi, Jehad Abubaker
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113102 (2014)
A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenin
Externí odkaz:
https://doaj.org/article/c9d84417c2784dd5a5fe32df75f8c657
Autor:
Osama Alsmadi, Gaurav Thareja, Fadi Alkayal, Ramakrishnan Rajagopalan, Sumi Elsa John, Prashantha Hebbar, Kazem Behbehani, Thangavel Alphonse Thanaraj
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74913 (2013)
The State of Kuwait is characterized by settlers from Saudi Arabia, Iran, and other regions of the Arabian Peninsula. The settlements and subsequent admixtures have shaped the genetics of Kuwait. High prevalence of recessive disorders and metabolic s
Externí odkaz:
https://doaj.org/article/441283e1d4fe47039c1b8e98ec27e698
ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals
Autor:
Motasem Melhem, Betty S. Chandy, Fadi Alkayal, Jehad Abubaker, Muath Alanbaei, Prashantha Hebbar, Mohamed Abu-Farha, Irina Al Khairi, Preethi Cherian, Emil Anoop, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Publikováno v:
Genes, Vol 12, Iss 755, p 755 (2021)
Genes
Volume 12
Issue 5
Genes
Volume 12
Issue 5
ANGPTL3 is an important regulator of lipid metabolism. Its inhibition in people with hypercholesteremia reduces plasma lipid levels dramatically. Genome-wide association studies have associated ANGPTL3 variants with lipid traits. Irisin, an exercise-
Autor:
Osama Alsmadi, Thangavel Alphonse Thanaraj, Mohamed Abu-Farha, Robert Sladek, Naser Elkum, Janne Pitkäniemi, Fadi Alkayal, Prashantha Hebbar, Rasheeba Iqbal, Sumi Elsa John, Fahd Al-Mulla, Jaakko Tuomilehto, Jehad Abubaker, Arshad Channanath
Publikováno v:
Human Genetics
While the Arabian population has a high prevalence of metabolic disorders, it has not been included in global studies that identify genetic risk loci for metabolic traits. Determining the transferability of such largely Euro-centric established risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b20447b4c28497fd8d6ae134c620961
http://hdl.handle.net/10138/353204
http://hdl.handle.net/10138/353204