Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Fadhl M. Alakwaa"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Breast cancer remains a significant health challenge with complex molecular mechanisms. While many studies have explored genetic markers in breast carcinogenesis, few have studied the potential impact of pharmacological interventions such as
Externí odkaz:
https://doaj.org/article/a2f4e31faf244fb5beef79b32c882faf
Autor:
Jennifer A. Schaub, Fadhl M. AlAkwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A. Otto, Dawit Demeke, John Hartman, Damian Fermin, Christopher L. O’Connor, Lalita Subramanian, Markus Bitzer, Roger Harned, Patricia Ladd, Laura Pyle, Subramaniam Pennathur, Ken Inoki, Jeffrey B. Hodgin, Frank C. Brosius III, Robert G. Nelson, Matthias Kretzler, Petter Bjornstad
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) remain incompletely understood. Single-cell RNA sequencing and morphometric data were collected from research kidney biopsies donated by young persons with type 2
Externí odkaz:
https://doaj.org/article/786e05c40b544ed683f2bef88a499a82
Autor:
Amy E. Rumora, Kai Guo, Fadhl M. Alakwaa, Signe T. Andersen, Evan L. Reynolds, Marit E. Jørgensen, Daniel R. Witte, Hatice Tankisi, Morten Charles, Masha G. Savelieff, Brian C. Callaghan, Troels S. Jensen, Eva L. Feldman
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 6, Pp 1292-1307 (2021)
Abstract Objective The global rise in type 2 diabetes is associated with a concomitant increase in diabetic complications. Diabetic polyneuropathy is the most frequent type 2 diabetes complication and is associated with poor outcomes. The metabolic s
Externí odkaz:
https://doaj.org/article/bcc06769c1254af4b7499a1a52dec913
Autor:
Fadhl M. Alakwaa
Publikováno v:
mSystems, Vol 5, Iss 2 (2020)
ABSTRACT As of today (7 April 2020), more than 81,000 people around the world have died from the coronavirus disease 19 (COVID-19) pandemic. There is no approved drug or vaccine for COVID-19, although more than 10 clinical trials have been launched t
Externí odkaz:
https://doaj.org/article/5fa5320a8d244bbd8f6138656f4e9881
Autor:
Junguk Hur, Ximena Paez-Colasante, Claudia Figueroa-Romero, Ting-wen Lo, Sami J Barmada, Michelle T Paulsen, Mats Ljungman, Fadhl M Alakwaa, Masha G Savelieff, Stephen A Goutman, Eva L Feldman
Publikováno v:
Human molecular genetics.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Its complex pathogenesis and phenotypic heterogeneity hinder therapeutic development and early diagnosis. Altered RNA metabolism is a recurrent pathophysiologic theme, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c9240be3e04353efa5957c46739da1
https://pubmed.ncbi.nlm.nih.gov/36219176
https://pubmed.ncbi.nlm.nih.gov/36219176
Autor:
Jennifer A. Schaub, Fadhl M. AlAkwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A. Otto, John Hartman, Damian Fermin, Christopher O’Connor, Markus Bitzer, Roger Harned, Patricia Ladd, Laura Pyle, Jeffrey B. Hodgin, Frank C. Brosius, Robert G. Nelson, Matthias Kretzler, Petter Bjornstad
The molecular mechanisms of SGLT2 inhibitors (SGLT2i) remain incompletely understood. Single-cell RNA sequencing and morphometrics data were collected from research kidney biopsies donated by participants with youth onset type 2 diabetes (T2D), aged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45438aab82804b47a696574b76264257
https://doi.org/10.1101/2022.07.23.22277943
https://doi.org/10.1101/2022.07.23.22277943
Autor:
Laura H. Mariani, Sean Eddy, Fadhl M. AlAkwaa, Phillip J. McCown, Jennifer L. Harder, Viji Nair, Felix Eichinger, Sebastian Martini, Adebowale D. Ademola, Vincent Boima, Heather N. Reich, Jamal El Saghir, Bradley Godfrey, Wenjun Ju, Emily C. Tanner, Virginia Vega-Warner, Noel L. Wys, Sharon G. Adler, Gerald B. Appel, Ambarish Athavale, Meredith A. Atkinson, Serena M. Bagnasco, Laura Barisoni, Elizabeth Brown, Daniel C. Cattran, Gaia M. Coppock, Katherine M. Dell, Vimal K. Derebail, Fernando C. Fervenza, Alessia Fornoni, Crystal A. Gadegbeku, Keisha L. Gibson, Laurence A. Greenbaum, Sangeeta R. Hingorani, Michelle A. Hladunewich, Jeffrey B. Hodgin, Marie C. Hogan, Lawrence B. Holzman, J. Ashley Jefferson, Frederick J. Kaskel, Jeffrey B. Kopp, Richard A. Lafayette, Kevin V. Lemley, John C. Lieske, Jen-Jar Lin, Rajarasee Menon, Kevin E. Meyers, Patrick H. Nachman, Cynthia C. Nast, Michelle M. O’Shaughnessy, Edgar A. Otto, Kimberly J. Reidy, Kamalanathan K. Sambandam, John R. Sedor, Christine B. Sethna, Pamela Singer, Tarak Srivastava, Cheryl L. Tran, Katherine R. Tuttle, Suzanne M. Vento, Chia-shi Wang, Akinlolu O. Ojo, Dwomoa Adu, Debbie S. Gipson, Howard Trachtman, Matthias Kretzler
Publikováno v:
Kidney international.
The diagnosis of nephrotic syndrome relies on clinical presentation and descriptive patterns of injury on kidney biopsies, but not specific to underlying pathobiology. Consequently, there are variable rates of progression and response to therapy with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de208f74baf467408c91da41f9fb8f45
https://pubmed.ncbi.nlm.nih.gov/36442540
https://pubmed.ncbi.nlm.nih.gov/36442540
Autor:
Kai Guo, Masha G Savelieff, Amy E Rumora, Fadhl M Alakwaa, Brian C Callaghan, Junguk Hur, Eva L Feldman
Publikováno v:
J Clin Endocrinol Metab
Context Peripheral neuropathy (PN) is a frequent prediabetes and type 2 diabetes (T2D) complication. Multiple clinical studies reveal that obesity and dyslipidemia can also drive PN progression, independent of glycemia, suggesting a complex interplay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a7f30d0fd72ab0238c1a3bc73c3f5f
https://europepmc.org/articles/PMC8947234/
https://europepmc.org/articles/PMC8947234/