Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Fadel SA"'
Autor:
Sacha J Pidot, Stephan Klatt, Louis S Ates, Wafa Frigui, Fadel Sayes, Laleh Majlessi, Hiroshi Izumi, Ian R Monk, Jessica L Porter, Vicki Bennett-Wood, Torsten Seemann, Ashley Otter, George Taiaroa, Gregory M Cook, Nicholas West, Nicholas J Tobias, John A Fuerst, Michael D Stutz, Marc Pellegrini, Malcolm McConville, Roland Brosch, Timothy P Stinear
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012440 (2024)
Reconstructing the evolutionary origins of Mycobacterium tuberculosis, the causative agent of human tuberculosis, has helped identify bacterial factors that have led to the tubercle bacillus becoming such a formidable human pathogen. Here we report t
Externí odkaz:
https://doaj.org/article/c05a679dcd724c87b14f99cec3647995
Autor:
Camille Sous, Wafa Frigui, Alexandre Pawlik, Fadel Sayes, Laurence Ma, Thomas Cokelaer, Roland Brosch
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Four species of non-tuberculous mycobacteria (NTM) rated as biosafety level 1 or 2 (BSL-1/BSL-2) organisms and showing higher genomic similarity with Mycobacterium tuberculosis (Mtb) than previous comparator species Mycobacterium kansasii an
Externí odkaz:
https://doaj.org/article/ba98bcfd71dc497e9da14c0fddcb9a9d
Autor:
Irene Pérez, Elena Campos-Pardos, Caridad Díaz, Santiago Uranga, Fadel Sayes, Francisca Vicente, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 1235-1248 (2022)
Cyclic (di)nucleotides act as universal second messengers endogenously produced by several pathogens. Specifically, the roles of c-di-AMP in Mycobacterium tuberculosis immunity and virulence have been largely explored, although its contribution to th
Externí odkaz:
https://doaj.org/article/816e8da91577439ba1f2ef6ffc3163c6
Autor:
Daria Bottai, Wafa Frigui, Fadel Sayes, Mariagrazia Di Luca, Dalila Spadoni, Alexandre Pawlik, Marina Zoppo, Mickael Orgeur, Varun Khanna, David Hardy, Sophie Mangenot, Valerie Barbe, Claudine Medigue, Laurence Ma, Christiane Bouchier, Arianna Tavanti, Gerald Larrouy-Maumus, Roland Brosch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mycobacterium tuberculosis (Mtb) modern strains emerged from a common progenitor after the loss of Mtb-specific deletion 1 region (TbD1). Here, the authors show that deletion of TbD1 correlates with enhanced Mtb virulence in animal models, mirroring
Externí odkaz:
https://doaj.org/article/dfe06d57f9b145fda733b5868dbc18ce
Autor:
Jacques Augenstreich, Evert Haanappel, Fadel Sayes, Roxane Simeone, Valérie Guillet, Serge Mazeres, Christian Chalut, Lionel Mourey, Roland Brosch, Christophe Guilhot, Catherine Astarie-Dequeker
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Mycobacterium tuberculosis (Mtb) synthesizes a variety of atypical lipids that are exposed at the cell surface and help the bacterium infect macrophages and escape elimination by the cell's immune responses. In the present study, we investigate the m
Externí odkaz:
https://doaj.org/article/11295162f6314b618572b0b6cb7b5ea9
Autor:
Irene Pérez, Santiago Uranga, Fadel Sayes, Wafa Frigui, Sofía Samper, Ainhoa Arbués, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio
Publikováno v:
EBioMedicine, Vol 55, Iss , Pp - (2020)
Background: Human tuberculosis (TB) is caused by a plethora of Mycobacterium tuberculosis complex (MTBC) strains belonging to seven phylogenetic branches. Lineages 2, 3 and 4 are considered “modern” branches of the MTBC responsible for the majori
Externí odkaz:
https://doaj.org/article/ad2a78e067c8439d9387b50429cbef1c
Autor:
Manal Alkan, Fadel Sayes, Abdulraouf Ramadan, Francois Machavoine, Michel Dy, Elke Schneider, Nathalie Thieblemont
Publikováno v:
AIMS Allergy and Immunology, Vol 2, Iss 3, Pp 126-140 (2018)
Basophils are effector cells that respond to protease allergens and parasites, thus contributing to allergic inflammation and Th2 differentiation. However, the molecular interactions through which pathogens promote activation as well as recruitment o
Externí odkaz:
https://doaj.org/article/0e13d56f3fa04862b29e5a7e84a83576
Autor:
Fadel Sayes, Catherine Blanc, Louis S. Ates, Nathalie Deboosere, Mickael Orgeur, Fabien Le Chevalier, Matthias I. Gröschel, Wafa Frigui, Ok-Ryul Song, Richard Lo-Man, Florence Brossier, Wladimir Sougakoff, Daria Bottai, Priscille Brodin, Pierre Charneau, Roland Brosch, Laleh Majlessi
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1072-1084 (2018)
Summary: The pathogenic potential of Mycobacterium tuberculosis largely depends on ESX secretion systems exporting members of the multigenic Esx, Esp, and PE/PPE protein families. To study the secretion and regulation patterns of these proteins while
Externí odkaz:
https://doaj.org/article/1d85853904c84b0698247d51802126df
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