Výsledky vyhledávání - "Fadel S. Alyaqoub"

Erythroblast transformation-specific transcription factor fusions in prostate cancer

Autor: Michelle Barbi de Moura, Fadel S. Alyaqoub, Gargi D. Basu, David W. Hall, Jess R Hoag, Janine R. LoBello, Frederick L. Baehner, Snehal Govind Thakkar, Steven Canfield

Publikováno v: Journal of Clinical Oncology. 41:224-224

224 Background: Common drivers in advanced prostate cancer (PC) involve fusions of the 3’ DNA binding domain-containing region of an Erythroblast Transformation Specific (ETS) transcription factor gene with a 5’ region of another gene, often one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f59598ff238347cbc3001d8acfd677b
https://doi.org/10.1200/jco.2023.41.6_suppl.224

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Prevalence and genomic landscape of BRAF alterations across gastrointestinal cancers

Autor: David Driscoll, Min Wang, Fadel S. Alyaqoub, Sameer S. Udhane, Szabolcs Szelinger, Aimee Jalkanen, David W. Hall, Jess R Hoag, Janine R. LoBello, Frederick L. Baehner, Snehal Govind Thakkar, Gargi D. Basu

Publikováno v: Journal of Clinical Oncology. 41:806-806

806 Background: BRAF V600E mutations can lead to activation of the MEK/ERK pathway. The combination of dabrafenib plus trametinib was recently FDA-approved for use in these BRAF V600E altered unresectable or metastatic cancers. BRAF non-V600 alterati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14ff5a3a6ef1a776ed3acbe2cac0c5a8
https://doi.org/10.1200/jco.2023.41.4_suppl.806

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Abstract 1263: Comprehensive genomic profiling to identify biomarkers predictive of response to immunotherapy

Autor: Pawan Noel, David W. Hall, Sameer S. Udhane, Min Wang, Fadel S. Alyaqoub, Szabolcs Szelinger, Audrey A. Ozols, Janine R. LoBello, Frederick L. Baehner, Gargi D. Basu

Publikováno v: Cancer Research. 82:1263-1263

Background: Immune-oncology (I-O) drugs show promise across multiple tumor types, and several biomarkers (BM) predict responsiveness to I-O therapy. In this descriptive study of clinical lab experience (2018-2021), we investigated the prevalence of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef4d2888a2cdc5a69b8e269a1924dc95
https://doi.org/10.1158/1538-7445.am2022-1263

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Comprehensive genomic profiling to identify gene alterations in DNA repair pathway across solid tumors

Autor: Kevin McDonnell, Gargi D. Basu, Jess W. Hoag, David W. Hall, Fadel S. Alyaqoub, Susan M. Dombrowski, Pawan Noel, Szabolcs Szelinger, Sameer S. Udhane, Min Wang, Janine R. LoBello, Snehal Govind Thakkar, Frederick L. Baehner, Christine Hong, Wai Park, Gregory Idos, Stacy W. Gray, Stephen B. Gruber

Publikováno v: Journal of Clinical Oncology. 40:3124-3124

3124 Background: Deleterious events in DNA damage response (DDR) are hallmarks of cancer associated with sensitivity to PARP inhibitors (PARPi) and immune checkpoint inhibitors (CPI). This study investigated DDR pathway alterations across solid tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57d09da0f0e1f365ecde60377964efe6
https://doi.org/10.1200/jco.2022.40.16_suppl.3124

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Comprehensive whole-exome and transcriptome profiling to identify actionable alterations associated with response to PARP inhibitors in breast cancer

Autor: Susan M. Dombrowski, Sameer S. Udhane, Gargi D. Basu, David W. Hall, Jess W. Hoag, Fadel S. Alyaqoub, Pawan Noel, Szabolcs Szelinger, Min Wang, Audrey A. Ozols, Janine R. LoBello, Snehal Govind Thakkar, Frederick L. Baehner, Joyce O'Shaughnessy

Publikováno v: Journal of Clinical Oncology. 40:1096-1096

1096 Background: The use of targeted therapies identified using genetic and genomic approaches is now routine in breast cancer (BC). In this clinical lab experience study the frequency of actionable somatic alterations in DNA repair pathway genes ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46c21ce22c8fbaa421b50d5560d70351
https://doi.org/10.1200/jco.2022.40.16_suppl.1096

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Genomic profiling of gastrointestinal cancers by comprehensive tumor-normal sequencing

Autor: Audrey A. Ozols, Szabolcs Szelinger, Thanemozhi G. Natarajan, Janine LoBello, Pawan Noel, Laurie J. Goodman, Susan M. Dombrowski, Fadel S. Alyaqoub, Gargi D. Basu, Thomas Royce

Publikováno v: Journal of Clinical Oncology. 39:109-109

109 Background: Gastrointestinal cancers (GIC) account for 26% of global cancer incidence and 35% of cancer-related deaths. We investigated the molecular landscape and therapeutic targets across 18 types of GIC using whole exome (WES) and whole trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76b6da12876ff816e38a09bbcaee003e
https://doi.org/10.1200/jco.2021.39.3_suppl.109

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ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis

Autor: Patrick O'Connell, Maja K. Blake, Yasser A. Aldhamen, Ariana M Angarita, Fadel S. Alyaqoub, David P W Rastall, Yuliya Pepelyayeva, Sarah G Roosa, Cristiane Pereira-Hicks, Sandra Raehtz, Laura R. McCabe, Abdulraouf M Abbas, Ashley M Raedy, Andrea Amalfitano

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Ankylosing spondylitis (AS) is a prototypical sero-negative autoimmune disease that affects millions worldwide. Single nucleotide polymorphisms in the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) gene have been linked to AS via GWAS studies, howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0e8724e7434906218866cf65bbc7e0
https://doi.org/10.1038/s41598-018-30159-5

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In vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses Against Extracellular Antigens¶

Autor: Christopher M. Waters, Benjamin J. Koestler, Eric L. Bruger, Andrea Amalfitano, Cristiane Pereira-Hicks, Fadel S. Alyaqoub, Sarah Godbehere, Yasser A. Aldhamen, Sergey S. Seregin

There is a compelling need for more effective vaccine adjuvants to augment induction of Ag-specific adaptive immune responses. Recent reports suggested the bacterial second messenger bis-(3′–5′)-cyclic-dimeric-guanosine monophosphate (c-di-GMP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa719c874618bbe8b98bc191c37ca434
https://europepmc.org/articles/PMC5523134/

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Modulation by bexarotene of mRNA expression of genes in mouse lung tumors

Autor: Fadel S. Alyaqoub, Vernon E. Steele, Yue Liu, Lianhui Tao, Ronald A. Lubet, Michael A. Pereira

Publikováno v: Molecular Carcinogenesis. 47:165-171

Bexarotene has demonstrated chemopreventive and therapeutic efficacy towards mouse lung tumors. Using specimens from our published study that demonstrated the efficacy of bexarotene, we report herein its ability to modulate mRNA expression of genes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b7e0431d86e3470d65178021fd9ab89
https://doi.org/10.1002/mc.20383

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Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT)

Autor: Vernon E. Steele, Ronald A. Lubet, Paula M. Kramer, William T. Gunning, Lianhui Tao, Michael A. Pereira, Fadel S. Alyaqoub

Publikováno v: Carcinogenesis. 27:2442-2447

Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib) or combinations of them were evaluated for prevention of lung tumors and for modulation of DNA methylation in tumors. Lung tumors were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6197fbe7eaac55e67b191fb3010c1dab
https://doi.org/10.1093/carcin/bgl088

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