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Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress

Autor: Nirun V. Hewawasam, Fadel Lhaf, Henry A. Taylor, Katrina Viloria, Amazon Austin, Aileen King, Peter Jones, Lucy Jones, Mark D. Turner, Natasha J. Hill

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

Abstract Regenerative medicine approaches to enhancing beta cell growth and survival represent potential treatments for diabetes. It is known that growth factors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with

Externí odkaz: https://doaj.org/article/0fb9c9d7a0d743c88c63bf86b8bef83e

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Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage

Autor: Amirhossein Sahebkar, Fadel Lhaf, Thozhukat Sathyapalan, Habib Yaribeygi

Publikováno v: Life sciences. 231

Apoptosis is a complicated process that involves activation of a series of intracellular signaling. Tissue injuries from diabetes mellitus mostly occur as a consequence of higher rate of apoptosis process due to activation of a series of molecular me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42065cf085df471d925ee77dffdb539a
https://pubmed.ncbi.nlm.nih.gov/31176776

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Novel Role for Matricellular Proteins in the Regulation of Islet β Cell Survival

Autor: Charlotte E. Edling, Aileen King, Fadel Lhaf, Hemant M. Kocher, Natasha J. Hill, Anthony J. Walker, Malin Flodström-Tullberg, David Mackintosh, Peter B. Jones, Rosemary McNeice, Claire L. Ryall, Katrina Viloria

Publikováno v: Journal of Biological Chemistry. 289:30614-30624

Understanding the mechanisms regulating islet growth and survival is critical for developing novel approaches to increasing or sustaining β cell mass in both type 1 and type 2 diabetes patients. Secreted protein acidic and rich in cysteine (SPARC) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9dd5fc6d1a5a5c4a3ea46648b799da7e
https://doi.org/10.1074/jbc.m114.573980

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Creating a 3D matricellular environment to promote islet expansion for diabetes therapy – the role of SPARC family proteins

Autor: Peter B. Jones, Katrina Viloria, Lucy Jones, Claire L. Ryall, Natasha J. Hill, Fadel Lhaf, Sharan Asher, Aileen King, Hemant M. Kocher, Amanda Dandagama

Publikováno v: The FASEB Journal. 29

Loss of the extracellular matrix following enzyme harvest of islets for transplantation renders them susceptible to a new environment, and is hypothesized to contribute to decreased graft function ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68d51b11f5343e0625400fe8cb88ac72
https://doi.org/10.1096/fasebj.29.1_supplement.719.16

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