Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Fabrizio Marcucci"'
Autor:
Marco Cordani, Federica Michetti, Ali Zarrabi, Atefeh Zarepour, Cristiano Rumio, Raffaele Strippoli, Fabrizio Marcucci
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 58, Iss , Pp 101076- (2024)
Glycolytic metabolism generates energy and intermediates for biomass production. Tumor-associated glycolysis is upregulated compared to normal tissues in response to tumor cell-autonomous or non-autonomous stimuli. The consequences of this upregulati
Externí odkaz:
https://doaj.org/article/379f684ce1884be49de8da074f41f891
Autor:
Fabrizio Marcucci, Cristiano Rumio
Publikováno v:
Cells, Vol 12, Iss 8, p 1124 (2023)
Reprogramming energy production from mitochondrial respiration to glycolysis is now considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to changes in their microenvironment (e.g., hypoxia, mechanical stress) that ar
Externí odkaz:
https://doaj.org/article/9c8d1a3a937b4ec0a6622d6029b638c1
Autor:
Fabrizio Marcucci, Cristiano Rumio
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)
Tumor cells often switch from mitochondrial oxidative metabolism to glycolytic metabolism even under aerobic conditions. Tumor cell glycolysis is accompanied by several nonenzymatic activities among which induction of drug resistance has important th
Externí odkaz:
https://doaj.org/article/9b9d95ebbfc64b38bab0b6fe740b2ac7
Autor:
Fabrizio Marcucci, Cristiano Rumio
Publikováno v:
Cells, Vol 11, Iss 6, p 1041 (2022)
Upregulation of glycolysis, induction of epithelial–mesenchymal transition (EMT) and macroautophagy (hereafter autophagy), are phenotypic changes that occur in tumor cells, in response to similar stimuli, either tumor cell-autonomous or from the tu
Externí odkaz:
https://doaj.org/article/a26a710963964bacb43d298c3d3641a9
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Cancer stem-like cells (CSC) represent a subpopulation of tumor cells with peculiar functionalities that distinguish them from the bulk of tumor cells, most notably their tumor-initiating potential and drug resistance. Given these properties, it appe
Externí odkaz:
https://doaj.org/article/ced2533a10094ddc881be68a5b78a07a
Autor:
Fabrizio Marcucci, Cristiano Rumio
Publikováno v:
Cells, Vol 10, Iss 4, p 872 (2021)
Antibodies against inhibitory immune checkpoint molecules (ICPMs), referred to as immune checkpoint inhibitors (ICIs), have gained a prominent place in cancer therapy. Several ICIs in clinical use have been engineered to be devoid of effector functio
Externí odkaz:
https://doaj.org/article/e84f59c7c08d442993b3363b683934c9
Autor:
Fabrizio Marcucci, Cristiano Rumio
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Tumor cells undergo epithelial-mesenchymal transition (EMT) or macroautophagy (hereafter autophagy) in response to stressors from the microenvironment. EMT ensues when stressors act on tumor cells in the presence of nutrient sufficiency, and mechanis
Externí odkaz:
https://doaj.org/article/d01da9652da64d65938905ba8684011f
Publikováno v:
Cells, Vol 8, Iss 5, p 460 (2019)
Carcinoma cells that undergo an epithelial-mesenchymal transition (EMT) and display a predominantly mesenchymal phenotype (hereafter EMT tumor cells) are associated with immune exclusion and immune deviation in the tumor microenvironment (TME). A lar
Externí odkaz:
https://doaj.org/article/ac8fd268788949149dc37c0d2416fa19
Autor:
Angelo Corti, Flavio Curnis, Fabrizio Marcucci, Mirco Ponzoni, Fabio Pastorino, Antonio Esposito, Tiziana Daniele, Mimma Bianco, Angelina Sacchi, Barbara Colombo, Anna Maria Gasparri, Alice Dallatomasina
The unbalanced production of pro- and antiangiogenic factors in tumors can lead to aberrant vasculature morphology, angiogenesis, and disease progression. In this study, we report that disease progression in various murine models of solid tumors is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58a69442573ca812c117db116517cd8
https://doi.org/10.1158/0008-5472.c.6511073.v1
https://doi.org/10.1158/0008-5472.c.6511073.v1
