Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Fabrizio Facchinetti"'
Autor:
Cataldo Martucci, Andrew Dennis Allen, Nadia Moretto, Valentina Bagnacani, Alessandro Fioni, Riccardo Patacchini, Maurizio Civelli, Gino Villetti, Fabrizio Facchinetti
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Inhibition of p38 mitogen-activated protein kinase (MAPKs) is a potential therapeutic approach for the treatment of acute and chronic pulmonary inflammatory conditions. Here, we report the in vitro and in vivo characterization of the anti-inflammator
Externí odkaz:
https://doaj.org/article/e024c104ed8c452b84fdb9c6bcc61046
Autor:
Hoang Oanh Nguyen, Valentina Salvi, Laura Tiberio, Fabrizio Facchinetti, Mirco Govoni, Gino Villetti, Maurizio Civelli, Ilaria Barbazza, Carolina Gaudenzi, Mauro Passari, Tiziana Schioppa, Francesca Sozio, Annalisa Del Prete, Silvano Sozzani, Daniela Bosisio
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Tanimilast is a novel and selective inhaled inhibitor of phosphodiesterase-4 in advanced clinical development for chronic obstructive pulmonary disease (COPD). Tanimilast is known to exert prominent anti-inflammatory activity when
Externí odkaz:
https://doaj.org/article/56874e035287459fa6afb42562fc9816
Autor:
Hoang Oanh Nguyen, Laura Tiberio, Fabrizio Facchinetti, Giulia Ripari, Valentina Violi, Gino Villetti, Valentina Salvi, Daniela Bosisio
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2254 (2023)
Inhibitors of phosphodiesterase-4 (PDE4) are small-molecule drugs that, by increasing the intracellular levels of cAMP in immune cells, elicit a broad spectrum of anti-inflammatory effects. As such, PDE4 inhibitors are actively studied as therapeutic
Externí odkaz:
https://doaj.org/article/e45bf96da3004bb39f640c5900d91441
Autor:
Sarah Campion, Amy Inselman, Belinda Hayes, Costanza Casiraghi, David Joseph, Fabrizio Facchinetti, Fabrizio Salomone, Georg Schmitt, Julia Hui, Karen Davis-Bruno, Karen Van Malderen, LaRonda Morford, Luc De Schaepdrijver, Lutz Wiesner, Stephanie Kourula, Suna Seo, Susan Laffan, Vijay Urmaliya, Connie Chen
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Increased research to improve preclinical models to inform the development of therapeutics for neonatal diseases is an area of great need. This article reviews five common neonatal diseases – bronchopulmonary dysplasia, retinopathy of prematurity,
Externí odkaz:
https://doaj.org/article/2b780bb945cf480c8f579328eb912ef4
Autor:
Hoang Oanh Nguyen, Tiziana Schioppa, Laura Tiberio, Fabrizio Facchinetti, Gino Villetti, Maurizio Civelli, Annalisa Del Prete, Francesca Sozio, Carolina Gaudenzi, Mauro Passari, Ilaria Barbazza, Silvano Sozzani, Valentina Salvi, Daniela Bosisio
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Phosphodiesterase 4 (PDE4) inhibitors are immunomodulatory drugs approved to treat diseases associated with chronic inflammatory conditions, such as COPD, psoriasis and atopic dermatitis. Tanimilast (international non-proprietary name of CHF6001) is
Externí odkaz:
https://doaj.org/article/40e0bf2dc169415384bee3348fb6ac74
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Chronic respiratory diseases are the third leading cause of death, behind cardiovascular diseases and cancer, affecting approximately 550 million of people all over the world. Most of the chronic respiratory diseases are attributable to asthma and ch
Externí odkaz:
https://doaj.org/article/622a70fbc2e348a4a103a94d0a8020b0
Autor:
Nozha Borjini, Sandra Sivilia, Alessandro Giuliani, Mercedes Fernandez, Luciana Giardino, Fabrizio Facchinetti, Laura Calzà
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-18 (2019)
Abstract Background Hypoxic-ischemic (HI) encephalopathy causes life-long morbidity and premature mortality in term neonates. Therapies in addition to whole-body cooling are under development to treat the neonate at risk for HI encephalopathy, but ar
Externí odkaz:
https://doaj.org/article/78d54d3ca7f44afd8bd7ab9cfff9e592
Autor:
Nicola J. Robertson, Kathryn Martinello, Ingran Lingam, Adnan Avdic-Belltheus, Christopher Meehan, Daniel Alonso-Alconada, Sara Ragab, Alan Bainbridge, Magdalena Sokolska, Mohamed Tachrount, Benita Middleton, David Price, Mariya Hristova, Xavier Golay, Annamaria Soliani Raschini, Giancarlo Aquino, Nicola Pelizzi, Fabrizio Facchinetti
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 240-251 (2019)
Therapeutic hypothermia is only partially protective for neonatal encephalopathy; there is an urgent need to develop treatments that augment cooling. Our objective was to assess safety, efficacy and pharmacokinetics of 5 and 15 mg/kg/24 h melatonin (
Externí odkaz:
https://doaj.org/article/7daf6abf1444477d8d26b24a12891d49
Autor:
Xinhui Wu, Vicky Verschut, Manon E. Woest, John-Poul Ng-Blichfeldt, Ana Matias, Gino Villetti, Alessandro Accetta, Fabrizio Facchinetti, Reinoud Gosens, Loes E. M. Kistemaker
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Transforming growth factor (TGF)-β-induced myofibroblast transformation and alterations in mesenchymal-epithelial interactions contribute to chronic lung diseases such as chronic obstructive pulmonary disease (COPD), asthma and pulmonary fibrosis. R
Externí odkaz:
https://doaj.org/article/f521fbe6701e4e26ac42b4ff7c85f16c
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 937 (2022)
Representing an important cause of long–term disability, term neonatal hypoxic-ischemic encephalopathy (HIE) urgently needs further research aimed at repurposing existing drug as well as developing new therapeutics. Since various experimental in vi
Externí odkaz:
https://doaj.org/article/6c67461013f14256891fb1717e7e82d1