Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Fabrizio E, Mancini"'
Autor:
Fabrizio E. Mancini, Paul E. A. Humphreys, Steven Woods, Nicola Bates, Sara Cuvertino, Julieta O’Flaherty, Leela Biant, Marco A. N. Domingos, Susan J. Kimber
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Osteoarthritis is the most common degenerative joint condition, leading to articular cartilage (AC) degradation, chronic pain and immobility. The lack of appropriate therapies that provide tissue restoration combined with the limited lifespa
Externí odkaz:
https://doaj.org/article/7f0785f7ef8b40a899ff7fca232187f7
Autor:
Philip A Lewis, Edina Silajdžić, Helen Smith, Nicola Bates, Christopher A Smith, Fabrizio E Mancini, David Knight, Chris Denning, Daniel R Brison, Susan J Kimber
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0299365 (2024)
With a view to developing a much-needed non-invasive method for monitoring the healthy pluripotent state of human stem cells in culture, we undertook proteomic analysis of the waste medium from cultured embryonic (Man-13) and induced (Rebl.PAT) human
Externí odkaz:
https://doaj.org/article/ab5be9b6d876451482c5833fcfe03b9d
Autor:
Paul E.A. Humphreys, Steven Woods, Nicola Bates, Kirsty M. Rooney, Fabrizio E. Mancini, Cerys Barclay, Julieta O’Flaherty, Franck P. Martial, Marco A.N. Domingos, Susan J. Kimber
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113502- (2023)
Summary: Optogenetics is a rapidly advancing technology combining photochemical, optical, and synthetic biology to control cellular behavior. Together, sensitive light-responsive optogenetic tools and human pluripotent stem cell differentiation model
Externí odkaz:
https://doaj.org/article/48364f8484364e76b3439618b536e1c7
Autor:
Christopher A Smith, Paul A Humphreys, Mark A Naven, Steven Woods, Fabrizio E Mancini, Julieta O'Flaherty, Qing-Jun Meng, Susan J Kimber
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280024 (2023)
Developmentally, the articular joints are derived from lateral plate (LP) mesoderm. However, no study has produced both LP derived prechondrocytes and preosteoblasts from human pluripotent stem cells (hPSC) through a common progenitor in a chemically
Externí odkaz:
https://doaj.org/article/d854047a6a744d6695132c3159eb8e28
Developmental principles informing human pluripotent stem cell differentiation to cartilage and bone
Autor:
Paul A, Humphreys, Fabrizio E, Mancini, Miguel J S, Ferreira, Steven, Woods, Leona, Ogene, Susan J, Kimber
Publikováno v:
Seminars in Cell & Developmental Biology. 127:17-36
Human pluripotent stem cells can differentiate into any cell type given appropriate signals and hence have been used to research early human development of many tissues and diseases. Here, we review the major biological factors that regulate cartilag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f15fedc719c5193bb5dbd90602f0dd
https://doi.org/10.1016/j.semcdb.2021.11.024
https://doi.org/10.1016/j.semcdb.2021.11.024
Autor:
Marco Domingos, Paul A. Humphreys, Leona Ogene, Miguel J. S. Ferreira, Susan J. Kimber, Michael Buckley, Fabrizio E Mancini
Publikováno v:
Ferreira, M J S, Mancini, F E, Humphreys, P A, Ogene, L, Buckley, M, Domingos, M A N & Kimber, S J 2022, ' Pluripotent stem cells for skeletal tissue engineering ', Critical Reviews in Biotechnology, vol. 42, no. 5, pp. 774-793 . https://doi.org/10.1080/07388551.2021.1968785
Here, we review the use of human pluripotent stem cells for skeletal tissue engineering. A number of approaches have been used for generating cartilage and bone from both human embryonic stem cells and induced pluripotent stem cells. These range from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d805f94d04cb81f0b1ffc46a2dfa11
https://doi.org/10.1080/07388551.2021.1968785
https://doi.org/10.1080/07388551.2021.1968785