Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study

Autor: Fabio Arturo Iannotti, Fabrizia De Maio, Elisabetta Panza, Giovanni Appendino, Orazio Taglialatela-Scafati, Luciano De Petrocellis, Pietro Amodeo, Rosa Maria Vitale

Publikováno v: Molecules, Vol 25, Iss 5, p 1119 (2020)

Phytocannabinoids (pCBs) are a large family of meroterpenoids isolated from the plant Cannabis sativa. Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the best investigated phytocannabinoids due to their relative abundance and interesting bi

Externí odkaz: https://doaj.org/article/d4c318dc563c4c15bea91e7fcec1a84a

Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells

Autor: Fabio Arturo Iannotti, Luzia da Silva Sampaio, Rosa T. Borelli-Tôrres, Fabrizia De Maio, Marcelo Einicker-Lamas, Vincenzo Di Marzo, Ricardo Augusto de Melo Reis, Fabiana Piscitelli, Luciana Veneziani

Publikováno v: Biochemical Pharmacology. 154:482-491

LLC-PK1 cells, an immortalized epithelial cell line derived from pig renal proximal tubules, express all the major players of the endocannabinoid system (ECS) such as CB1, CB2 and TRPV1 receptors, as well as the main enzymes involved in the biosynthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::086ba1da430dced05bfd09b3e25d25cf
https://doi.org/10.1016/j.bcp.2018.06.005

In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator

Autor: Andrea Martella, Fabio Arturo Iannotti, Joshua S. Waxman, Rosa Maria Vitale, Maria Letizia Ciavatta, Enrico D'Aniello, Alessandra Gentile, Lauren G Falkenberg, Pietro Amodeo, Vincenzo Di Marzo, Fabrizia De Maio, Margherita Gavagnin

Publikováno v: Marine Drugs, Vol 17, Iss 2, p 110 (2019)
Marine drugs 17 (2019). doi:10.3390/md17020110
info:cnr-pdr/source/autori:D'Aniello E.; Iannotti F.A.; Falkenberg L.G.; Martella A.; Gentile A.; De Maio F.; Ciavatta M.L.; Gavagnin M.; Waxman J.S.; Di Marzo V.; Amodeo P.; Vitale R.M./titolo:In silico identification and experimental validation of (-)-muqubilin A, a marine norterpene peroxide, as PPARalpha%2Fgamma-RXRalpha agonist and RARalpha positive allosteric modulator/doi:10.3390%2Fmd17020110/rivista:Marine drugs/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:17
Marine Drugs
Volume 17
Issue 2

The nuclear receptors (NRs) RAR&alpha
RXR&alpha
PPAR&alpha
and PPAR&gamma
represent promising pharmacological targets for the treatment of neurodegenerative diseases. In the search for molecules able to simultaneously target all t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7655f073c0a88e710e97a423af00e43
https://www.mdpi.com/1660-3397/17/2/110

Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na

Autor: Luzia S, Sampaio, Fabio A, Iannotti, Luciana, Veneziani, Rosa T, Borelli-Tôrres, Fabrizia, De Maio, Fabiana, Piscitelli, Ricardo A M, Reis, Vincenzo, Di Marzo, Marcelo, Einicker-Lamas

Publikováno v: Biochemical pharmacology. 154

LLC-PK1 cells, an immortalized epithelial cell line derived from pig renal proximal tubules, express all the major players of the endocannabinoid system (ECS) such as CB1, CB2 and TRPV1 receptors, as well as the main enzymes involved in the biosynthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ccbe5773aabdb1c288fd38e0d14b22b
https://pubmed.ncbi.nlm.nih.gov/29890144