Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Fabrice Vandeput"'
Autor:
Eddie Yang, Jennifer L. Liras, Christine C. Orozco, Christopher W. am Ende, Matthew A. Movsesian, Jayvardhan Pandit, John M. Humphrey, Stephen Jenkinson, Frank S. Menniti, Thomas Allen Chappie, Spiros Liras, Stacey L. Becker, Felix Vajdos, Fabrice Vandeput
Publikováno v:
Journal of medicinal chemistry. 61(10)
We disclose the discovery and X-ray cocrystal data of potent, selective quinazoline inhibitors of PDE1. Inhibitor (S)-3 readily attains free plasma concentrations above PDE1 IC50 values and has restricted brain access. The racemic compound 3 inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad70863e6c50adf198b09386b95c77c
https://pubmed.ncbi.nlm.nih.gov/29718668
https://pubmed.ncbi.nlm.nih.gov/29718668
Autor:
Herbert Schuster, Franz Rüschendorf, Carolin Schächterle, Hermann Haller, Anita Rauch, Thomas F. Wienker, Eireen Bartels-Klein, Fabrice Vandeput, Sylvia Bähring, Martin G. Bialer, Friedrich C. Luft, Thomas Liehr, Andreas Busjahn, Anja Weise, Stefan Mundlos, Jurg Ott, Irene Hollfinger, Matthew A. Movsesian, Astrid Mühl, Ramin Naraghi, Maolian Gong, Fatimunnisa Qadri, Enno Klussmann, Herbert Schulz, Jens Jordan, Jochen Hecht, Knut Mai, Martin Kann, Katharina Rittscher, Carsten Lindschau, Nihat Bilginturan, Ghislaine Plessis, Dmitri Parkhomchuk, Peter Krawitz, David Chitayat, Okan Toka, Jens Tank, Maxwell Hopp, Atakan Aydin, Martin Vaegler, Philipp G. Maass, Norbert Hubner, Hakan R. Toka, Yvette Wefeld-Neuenfeld, Lars O Hattenbach, Russell Hodge, Sigmar Stricker
Publikováno v:
Nature Genetics
Cardiovascular disease is the most common cause of death worldwide, and hypertension is the major risk factor(1). Mendelian hypertension elucidates mechanisms of blood pressure regulation. Here we report six missense mutations in PDE3A (encoding phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b685bff7495f8caaf66c0e4cf9a9a5e6
https://doi.org/10.1038/ng.3302
https://doi.org/10.1038/ng.3302
Autor:
Faiyaz Ahmad, Eva Degerman, Matthew A. Movsesian, Frank Goetz, Enno Klussmann, Fabrice Vandeput, Weixing Shen, Vincent C. Manganiello, Nicolas Szabo-Fresnais, Judith Krall
Publikováno v:
Journal of Biological Chemistry. 290:6763-6776
Cyclic nucleotide phosphodiesterase 3A (PDE3) regulates cAMP-mediated signaling in the heart, and PDE3 inhibitors augment contractility in patients with heart failure. Studies in mice showed that PDE3A, not PDE3B, is the subfamily responsible for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7e449826ce2c0d6ebf3b19a5a192a9c
https://doi.org/10.1074/jbc.m115.638585
https://doi.org/10.1074/jbc.m115.638585
Autor:
Nicolas Szabo-Fresnais, Faiyaz Ahmad, Roger J. Hajjar, Changwon Kho, Mark Hazel, Fabrice Vandeput, Matthew A. Movsesian, Judith Krall, Allan J. Dunlop, Miles D. Houslay, James A. Wohlschlegel, Vincent C. Manganiello, Ahyoung Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 110:19778-19783
Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use increases mortality in patients with heart failure. Two isoforms in cardiac myocytes, PDE3A1 and PDE3A2, have identical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2daeb8abfda84511fc531ab4da5d786b
https://doi.org/10.1073/pnas.1305427110
https://doi.org/10.1073/pnas.1305427110
Autor:
Matthew A. Movsesian, Judith Krall, Vincent A. Florio, Rakesh C. Kukreja, Fabrice Vandeput, Fadi N Salloum, Ramzi A Ockaili, Sharron H. Francis, Jackie D. Corbin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 330:884-891
In mouse models of cardiac disease, the type 5 (PDE5)-selective cyclic nucleotide phosphodiesterase inhibitor sildenafil has antihypertrophic and cardioprotective effects attributable to the inhibition of cGMP hydrolysis. To investigate the relevance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43bf9519d6acda2d35649f2a5a0b36a
https://doi.org/10.1124/jpet.109.154468
https://doi.org/10.1124/jpet.109.154468
Autor:
Enno Klussmann, Judith Krall, Vincent C. Manganiello, Nicolas Szabo-Fresnais, Eva Degerman, Frank Goetz, Faiyaz Ahmad, Weixing Shen, Fabrice Vandeput, Matthew A. Movsesian
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::200aeb9bf4480bd936c26fbc5208ca2a
https://doi.org/10.1096/fasebj.29.1_supplement.728.24
https://doi.org/10.1096/fasebj.29.1_supplement.728.24
Autor:
Leonardo Furlan, Stuart A. Nicklin, Frank Gesellchen, Laura Ashley Fields, Ivar Sjaastad, Graham Hamilton, Judith Krall, Matthew A. Movsesian, Giuliano Dodoni, Luisa Mancuso, Manuela Zaccolo, Jan Magnus Aronsen, Craig Livie, Konstantinos Lefkimmiatis, Alessandra Stangherlin, Fabrice Vandeput, Nicolas Szabo-Fresnais, Anna Zoccarato, Yuan Yan Sin, Anna Terrin, Nicoletta C. Surdo, Veronica Corsetti, Delyth Graham, George S. Baillie, He Jiang
Publikováno v:
Circulation research. 117(8)
Rationale : Chronic elevation of 3′-5′-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodeling and cardiac hypertrophy. However, enhancement of particular aspects of cAMP/protein kinase A signaling seems to be ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97658dd4c46b3d9c9366fedfeaece51
https://pubmed.ncbi.nlm.nih.gov/26243800
https://pubmed.ncbi.nlm.nih.gov/26243800
Publikováno v:
Endocrinology. 144:1341-1349
We have investigated the role of the different classes of MAPKs, i.e. ERKs, c-Jun N-terminal kinases (JNKs), and p38 MAPK in the proliferation of dog and human thyroid epithelial cells (thyrocytes) in primary cultures. In these cells, TSH, acting thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29376ed2f21cc35421c469be102a9d3
https://doi.org/10.1210/en.2001-211316
https://doi.org/10.1210/en.2001-211316
Autor:
S. Perpete, Sarah Dremier, Françoise Lamy, Katia Coulonval, Sandrine Deleu, Serge Clément, Nathalie Fortemaison, Fabrice Vandeput, Catherine Ledent, Stéphane Schurmans, Pierre P. Roger, Jacques Emile Dumont, Carine Maenhaut, A. Van Keymeulen
Publikováno v:
Annals of the New York Academy of Sciences. 968:106-121
Cyclic AMP has been shown to inhibit cell proliferation in many cell types and to activate it in some. The latter has been recognized only lately, thanks in large part to studies on the regulation of thyroid cell proliferation in dog thyroid cells. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825cd0ba86d4028c46bd7db6bc0d3213
https://doi.org/10.1111/j.1749-6632.2002.tb04330.x
https://doi.org/10.1111/j.1749-6632.2002.tb04330.x
Autor:
Jacques Emile Dumont, Sara C. Kozma, Robert Stein, Katia Coulonval, Françoise Lamy, Fabrice Vandeput
Publikováno v:
Biochemical Journal. 348:351-358
The proliferation of most normal cells depends on the co-operation of several growth factors and hormones, each with a specific role, but the key events involved in the action of each necessary stimulant remain largely uncharacterized. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69de39cb14bc6cab1c5eb99f8d3a82c1
https://doi.org/10.1042/bj3480351
https://doi.org/10.1042/bj3480351