Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Fabrice Turlais"'
Autor:
Gary J. Spencer, Ulf Bremberg, Matthis Geitmann, Allan M. Jordan, Sharon Cartic, Alison E. McGonagle, Daniel P. Mould, Fabrice Turlais, Donald J. Ogilvie, Tim C. P. Somervaille, Cristina Alli, Alba Maiques-Diaz
Publikováno v:
Mould, D, Alli, C, Bremberg, U, Cartic, S, Jordan, A, Geitmann, M, Maiques-Diaz, A, Mcgonagle, A, Somervaille, T, Spencer, G, Turlais, F & Ogilvie, D 2017, ' Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1 ', Journal of Medicinal Chemistry . https://doi.org/10.1021/acs.jmedchem.7b00462
Inhibition of lysine specific demethylase 1 (LSD1) has been shown to induce the differentiation of leukemia stem cells in acute myeloid leukaemia (AML). Irreversible inhibitors developed from the non-specific inhibitor tranylcypromine have entered cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1d2604e30d84808470c33b378f0fae
https://doi.org/10.1021/acs.jmedchem.7b00462
https://doi.org/10.1021/acs.jmedchem.7b00462
Autor:
Alison E. McGonagle, Graeme J. Thomson, Paul Depledge, Gemma Hopkins, Bohdan Waszkowycz, Mathew Rushbrooke, Nicola Hamilton, Allan M. Jordan, Kate M. Smith, James R. Hitchin, Daniel P. Mould, Helen F. Small, Fabrice Turlais, Ian D. Waddell, Amanda J. Watson, Laura A. Maguire, Donald J. Ogilvie, Niall M. Hamilton, Ali Raoof
Publikováno v:
Journal of Medicinal Chemistry. 56:6352-6370
The recently discovered enzyme tyrosyl-DNA phosphodiesterase 2 (TDP2) has been implicated in the topoisomerase-mediated repair of DNA damage. In the clinical setting, it has been hypothesized that TDP2 may mediate drug resistance to topoisomerase II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd406774930ae07cfd5c692dcb66382
https://doi.org/10.1021/jm400568p
https://doi.org/10.1021/jm400568p
Autor:
Susanne, Scheipl, Michelle, Barnard, Lucia, Cottone, Mette, Jorgensen, David H, Drewry, William J, Zuercher, Fabrice, Turlais, Hongtao, Ye, Ana P, Leite, James A, Smith, Andreas, Leithner, Peter, Möller, Silke, Brüderlein, Naomi, Guppy, Fernanda, Amary, Roberto, Tirabosco, Sandra J, Strauss, Nischalan, Pillay, Adrienne M, Flanagan
Publikováno v:
The Journal of pathology. 239(3)
Chordoma is a rare malignant bone tumour with a poor prognosis and limited therapeutic options. We undertook a focused compound screen (FCS) against 1097 compounds on three well-characterized chordoma cell lines; 154 compounds were selected from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6434cfd43da6f88f8f3e4be88365a03
https://pubmed.ncbi.nlm.nih.gov/27538356
https://pubmed.ncbi.nlm.nih.gov/27538356
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 11:16-22
We describe a system for collecting usage metrics from widely distributed automation systems. An application that records and stores usage data centrally, calculates run times, and charts the data was developed. Data were collected over 20 months fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d427b52f7cbf76224cb9b215d52e9b5d
https://doi.org/10.1016/j.jala.2005.09.001
https://doi.org/10.1016/j.jala.2005.09.001
Autor:
Siobhan M. Hughes, Patricia Haus, Vanessa Petrucci, Thomas Leiser, Matthew J. Fuchter, S.S. Samlal, Andrew J. P. White, Robert J.K. Wood, Stephen Neidle, Fabrice Turlais, Matthias G. J. Baud, Ai Ching Wong, Lakjaya Buluwela, Franz-Josef Meyer-Almes, Mekala Gunaratnam
Publikováno v:
Journal of medicinal chemistry. 55(4)
Psammaplin A (11c) is a marine metabolite previously reported to be a potent inhibitor of two classes of epigenetic enzymes: histone deacetylases and DNA methyltransferases. The design and synthesis of a focused library based on the psammaplin A core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746e44178705daaa043dcd345e13d517
https://pubmed.ncbi.nlm.nih.gov/22280363
https://pubmed.ncbi.nlm.nih.gov/22280363
Autor:
James R. Hitchin, Graeme J. Thomson, Mandy Watson, Mathew Rushbrooke, Laura A. Maguire, Gemma Hopkins, Nicola Hamilton, Ian D. Waddell, James W. Smith, Donald J. Ogilvie, Ali Raoof, Alison E. McGonagle, Daniel P. Mould, Kate Smilth, Paul Depledge, Allan M. Jordan, Fabrice Turlais
Publikováno v:
Cancer Research. 73:3324-3324
Topoisomerases (topo) regulate DNA topology by the transient cleavage and re-ligation of DNA during transcription and replication. Topo II poisons such as etoposide can induce abortive DNA strand breaks in which topo II remains covalently bound to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7030a4699256ed6b417e10e30de111
https://doi.org/10.1158/1538-7445.am2013-3324
https://doi.org/10.1158/1538-7445.am2013-3324
Autor:
Siobhan M. Hughes, Thomas Leiser, Mekala Gunaratnam, S.S. Samlal, Franz-Josef Meyer-Almes, Fabrice Turlais, Ai Ching Wong, Robert J.K. Wood, Stephen Neidle, Matthias G. J. Baud, Lakjaya Buluwela, Matthew J. Fuchter
Publikováno v:
Molecular Cancer Therapeutics. 10:B166-B166
Naturally isolated products continue to play a significant role in anticancer drug discovery. In line with our interest in small molecule compounds which effect epigenetic gene regulation, we are interested in the structural and biological properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19b546df9e0869de1d670de99e2b238
https://doi.org/10.1158/1535-7163.targ-11-b166
https://doi.org/10.1158/1535-7163.targ-11-b166