The Amaryllidaceae Isocarbostyril Narciclasine Induces Apoptosis By Activation of the Death Receptor and/or Mitochondrial Pathways in Cancer Cells But Not in Normal Fibroblasts

Autor: Patrick Dumont, Laurent Ingrassia, Sébastien Rouzeau, Fabrice Ribaucour, Stéphanie Thomas, Isabelle Roland, Francis Darro, Florence Lefranc, Robert Kiss

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 9, Pp 766-776 (2007)

Our study has shown that the Amaryllidaceae isocarbostyril narciclasine induces marked apoptosismediated cytotoxic effects in human cancer cells but not in normal fibroblasts by triggering the activation of the initiator caspases of the death recepto

Externí odkaz: https://doaj.org/article/ca80f17552de41f8b34ab1b87db31a05

2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a Novel Nonhematotoxic Naphthalimide Derivative with Potent Antitumor Activity

Autor: Florence Lefranc, Tine Mahieu, Jean-François Gaussin, Mohamed El Yazidi, Sébastien Sauvage, Jerome Tuti, Janique Dewelle, Tatjana Mijatovic, Robert Kiss, Francis Darro, Fabrice Ribaucour, Eric Van Quaquebeke, Gentiane Simon, Patrick Dumont, Frank Van Vynckt

Publikováno v: Journal of Medicinal Chemistry. 50:4122-4134

Amonafide (1), a naphthalimide which binds to DNA by intercalation and poisons topoisomerase IIalpha, has demonstrated activity in phase II breast cancer trials, but has failed thus far to enter clinical phase III because of dose-limiting bone marrow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c38f4299aaccb6644f857048f70a3ca
https://doi.org/10.1021/jm070315q

Influence of antral follicle size on oocyte characteristics and embryo development in the bovine

Autor: Rozenn Dalbies-Tran, Anne-Sophie Lequarré, Henrik Callesen, Céline Vigneron, Pascal Mermillod, Peter Holm, Fabrice Ribaucour, Isabelle Donnay

Publikováno v: Theriogenology
Theriogenology, Elsevier, 2005, 63, pp.841-859
Lequarré, A S, Vigneron, C, Holm, P, Donnay, I, Dalbiès-Tran, R, Callesen, H & Mermillod, P 2005, ' Influence of antral follicle size on oocyte characteristics and embryo development in the bovine ', Theriogenology, vol. 63, no. 3, pp. 841-859 . https://doi.org/10.1016/j.theriogenology.2004.05.015

The developmental competence of bovine oocytes isolated from antral follicles of different sizes was assessed in three European laboratories (Belgium, UCL; Denmark, DIAS; France, INRA). Using the same protocol for in vitro production of embryos, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0411b93e7cbe2f68eff6809ec850367
https://doi.org/10.1016/j.theriogenology.2004.05.015

The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts

Autor: Francis Darro, Robert Kiss, Fabrice Ribaucour, Patrick Dumont, Florence Lefranc, Isabelle Roland, Laurent Ingrassia, Stéphanie Thomas, Sébastien Rouzeau

Publikováno v: NeoPlasia : an international journal of oncology research, Vol. 9, no. 9, p. 766-776 (2007)
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 9, Pp 766-776 (2007)

Our study has shown that the Amaryllidaceae isocarbostyril narciclasine induces marked apoptosismediated cytotoxic effects in human cancer cells but not in normal fibroblasts by triggering the activation of the initiator caspases of the death recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877d4a9d4a9b3b4c340eeb576cc8f6ac
https://hdl.handle.net/2078.1/89964

2,2,2-Trichloro-N-(2-2-(dimethylamino)ethyl-1,3-dioxo-2,3-dihydro-1H-benzodeisoquinolin- 5-ylcarbamoyl)acetamide (UNBS3157), a Novel Nonhematotoxic Naphthalimide Derivative with Potent Antitumor Activity.

Autor: Eric Van Quaquebeke, Tine Mahieu, Patrick Dumont, Janique Dewelle, Fabrice Ribaucour, Gentiane Simon, Sébastien Sauvage, Jean-François Gaussin, Jérôme Tuti, Mohamed El Yazidi, Frank Van Vynckt, Tatjana Mijatovic, Florence Lefranc, Francis Darro, Robert Kiss

Publikováno v: Journal of Medicinal Chemistry; Aug2007, Vol. 50 Issue 17, p4122-4134, 13p