Zobrazeno 1 - 10 of 74 pro vyhledávání: '"Fabrice Morel"'
1
Akademický článek
Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity
Autor: Manuel Vlach, Nicolas Quesnot, Hélène Dubois-Pot-Schneider, Catherine Ribault, Yann Verres, Kilian Petitjean, Claudine Rauch, Fabrice Morel, Marie-Anne Robin, Anne Corlu, Pascal Loyer
Publikováno v: Sensors, Vol 19, Iss 10, p 2245 (2019)
Human hepatoma HepaRG cells express most drug metabolizing enzymes and constitute a pertinent in vitro alternative cell system to primary cultures of human hepatocytes in order to determine drug metabolism and evaluate the toxicity of xenobiotics. In
Externí odkaz: https://doaj.org/article/798c9c749f6646ef8bc3f35efb143899
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2
Akademický článek
The rs3957357C>T SNP in GSTA1 Is Associated with a Higher Risk of Occurrence of Hepatocellular Carcinoma in European Individuals.
Autor: Hanane Akhdar, Said El Shamieh, Orlando Musso, Romain Désert, Wissam Joumaa, Dominique Guyader, Caroline Aninat, Anne Corlu, Fabrice Morel
Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167543 (2016)
Glutathione S-transferases (GSTs) detoxify toxic molecules by conjugation with reduced glutathione and regulate cell signaling. Single nucleotide polymorphisms (SNPs) of GST genes have been suggested to affect GST functions and thus to increase the r
Externí odkaz: https://doaj.org/article/06bf2c0e15e94a8f97aa2dba313e1a19
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3
Akademický článek
Regulation of Signal Transduction by Glutathione Transferases
Autor: Julie Pajaud, Sandeep Kumar, Claudine Rauch, Fabrice Morel, Caroline Aninat
Publikováno v: International Journal of Hepatology, Vol 2012 (2012)
Glutathione transferases (GST) are essentially known as enzymes that catalyse the conjugation of glutathione to various electrophilic compounds such as chemical carcinogens, environmental pollutants, and antitumor agents. However, this protein family
Externí odkaz: https://doaj.org/article/bb8efc0684fc4d4799923a833c9c5d06
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4
Akademický článek
Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat.
Autor: Ismail Ben Mosbah, Yann Mouchel, Julie Pajaud, Catherine Ribault, Catherine Lucas, Alexis Laurent, Karim Boudjema, Fabrice Morel, Anne Corlu, Philippe Compagnon
Publikováno v: PLoS ONE, Vol 7, Iss 11, p e50235 (2012)
Ischemia/reperfusion injury occurring during liver transplantation is mainly due to the generation of reactive oxygen species (ROS) upon revascularization. Thus, delivery of antioxidant enzymes might reduce the deleterious effects of ROS and improve
Externí odkaz: https://doaj.org/article/952e8421d6f1408eadfd6984eb1b75fd
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6
Data from Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance
Autor: Anne Corlu, Florian Cabillic, Orlando Musso, Bernard Fromenty, Fabrice Morel, Claudine Rauch, Denise Glaise, Yoann Daniel, Romain Désert, Hélène Dubois-Pot-Schneider, Karim Fekir
Human hepatocellular carcinoma (HCC) heterogeneity promotes recurrence and therapeutic resistance. We recently demonstrated that inflammation favors hepatocyte retrodifferentiation into progenitor cells. Here, we identify the molecular effectors that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27c25ecda1bad6a4344a49c70c81091d
https://doi.org/10.1158/0008-5472.c.6511617.v1
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7
Retrodifferentiation of human tumor hepatocytes to stem cells leads to metabolic reprogramming and chemoresistance
Autor: Orlando Musso, Anne Corlu, Bernard Fromenty, Karim Fekir, Florian Cabillic, Hélène Dubois-Pot-Schneider, Fabrice Morel, Romain Desert, Yoann Daniel, Claudine Rauch, Denise Glaise
Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2019, 79 (8), pp.1869-1883. ⟨10.1158/0008-5472.CAN-18-2110⟩
Cancer Research, 2019, 79 (8), pp.1869-1883. ⟨10.1158/0008-5472.CAN-18-2110⟩
Human hepatocellular carcinoma (HCC) heterogeneity promotes recurrence and therapeutic resistance. We recently demonstrated that inflammation favors hepatocyte retrodifferentiation into progenitor cells. Here, we identify the molecular effectors that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da331cf1b7393a29d80ac9b4ca8ee627
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02087900/document
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8
Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation
Autor: Anne Corlu, Sandrine Bruel, Nicolas J. Cabaton, Fabien Jourdan, Florence Vinson, Hélène Dubois-Pot-Schneider, Clément Frainay, Cécile Canlet, Daniel Zalko, Elodie Person, Fabrice Morel, Marie-Anne Robin, Florence Maurier, Nathalie Poupin, Bernard Fromenty
Publikováno v: Journal of Proteome Research
Journal of Proteome Research, American Chemical Society, 2019, 18 (1), pp.204-216. ⟨10.1021/acs.jproteome.8b00524⟩
Journal of Proteome Research, 2019, 18 (1), pp.204-216. ⟨10.1021/acs.jproteome.8b00524⟩
International audience; Being able to explore the metabolism of broad metabolizing cells is of critical importance in many research fields. This article presents an original modeling solution combining metabolic network and omics data to identify mod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1770ff94b676a0f76495f7be94eb31
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01937261
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9
Efficient transfection of Xenobiotic Responsive Element-biosensor plasmid using diether lipid and phosphatidylcholine liposomes in differentiated HepaRG cells
Autor: Nicolas Quesnot, Jelena Jeftić, Nicolas Ripoche, Maxime Demazeau, Fabrice Morel, Fabienne Gauffre, Thierry Benvegnu, Pascal Loyer, Claudine Rauch
Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2017, 524 (1-2), pp.268-278. ⟨10.1016/j.ijpharm.2017.03.080⟩
International Journal of Pharmaceutics, 2017, 524 (1-2), pp.268-278. ⟨10.1016/j.ijpharm.2017.03.080⟩
International audience; In this study, we evaluated cationic liposomes prepared from diether-NH2 and egg phosphatidylcholine (EPC) for in vitro gene delivery. The impact of the lipid composition, i.e. the EPC and Diether-NH2 molar ratio, on in vitro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee258a14ed83e9bc3dca3155890970e2
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01518045/document
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10
Evaluation of genotoxicity using automated detection of γH2AX in metabolically competent HepaRG cells
Autor: Pascal Loyer, Sophie Martinais, Marie-Anne Robin, Nicolas Quesnot, Fabrice Morel, Denise Glaise, Karine Rondel, Marc Audebert
Publikováno v: Mutagenesis
Mutagenesis, 2016, 31 (1), pp.43-50. ⟨10.1093/mutage/gev059⟩
Mutagenesis, Oxford University Press (OUP), 2016, 31 (1), pp.43-50. ⟨10.1093/mutage/gev059⟩
International audience; The in situ detection of γH2AX was recently reported to be a promising biomarker of genotoxicity. In addition, the human HepaRG hepatoma cells appear to be relevant for investigating hepatic genotoxicity since they express mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33df8b516017e07ba351764b0b103b44
https://univ-rennes.hal.science/hal-01187325
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