APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

Autor: Sophie Uzureau, Laurence Lecordier, Pierrick Uzureau, Dorle Hennig, Jonas H. Graversen, Fabrice Homblé, Pepe Ekulu Mfutu, Fanny Oliveira Arcolino, Ana Raquel Ramos, Rita M. La Rovere, Tomas Luyten, Marjorie Vermeersch, Patricia Tebabi, Marc Dieu, Bart Cuypers, Stijn Deborggraeve, Marion Rabant, Christophe Legendre, Søren K. Moestrup, Elena Levtchenko, Geert Bultynck, Christophe Erneux, David Pérez-Morga, Etienne Pays

Publikováno v: Cell Reports, Vol 30, Iss 11, Pp 3821-3836.e13 (2020)

Summary: The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins

Externí odkaz: https://doaj.org/article/3266daf22f2c432796add4a1fbe1a576

Dual mechanism of ion permeation through VDAC revealed with inorganic phosphate ions and phosphate metabolites.

Autor: Eva-Maria Krammer, Giang Thi Vu, Fabrice Homblé, Martine Prévost

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0121746 (2015)

In the exchange of metabolites and ions between the mitochondrion and the cytosol, the voltage-dependent anion channel (VDAC) is a key element, as it forms the major transport pathway for these compounds through the mitochondrial outer membrane. Nume

Externí odkaz: https://doaj.org/article/48048029e50441009c96eda55983d6a2

Improvement of Diabetes Symptoms and Complications by an Aqueous Extract ofLinum usitatissimum(L.) Seeds in Alloxan-Induced Diabetic Mice

Autor: Fabrice Homblé, Samia Bouzghaya, Mohamed Amri

Publikováno v: Journal of medicinal food, 23 (10

Although progress has been made to show the role of raw flaxseed and flaxseed extracts in health promotion, identification of mechanism(s) of action and molecule(s) underpinning beneficial effects largely remain unknown. The present study evaluated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3485ec7fe3cd6b02d0bebe6d092a90bd
https://doi.org/10.1089/jmf.2019.0205

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

Autor: Geert Bultynck, Laurence Lecordier, Ana Raquel Ramos, Stijn Deborggraeve, Marjorie Vermeersch, Patricia Tebabi, Elena Levtchenko, Christophe Legendre, Søren K. Moestrup, Pepe Ekulu Mfutu, Tomas Luyten, Sophie Uzureau, Christophe Erneux, Marc Dieu, Dorle Hennig, David Perez-Morga, Pierrick Uzureau, Rita Rm La Rovere, Etienne Pays, Bart Cuypers, Jonas Graversen, Marion Rabant, Fanny Oliveira Arcolino, Fabrice Homblé

Publikováno v: Uzureau, S, Lecordier, L, Uzureau, P, Hennig, D, Graversen, J H, Homblé, F, Mfutu, P E, Oliveira Arcolino, F, Ramos, A R, La Rovere, R M, Luyten, T, Vermeersch, M, Tebabi, P, Dieu, M, Cuypers, B, Deborggraeve, S, Rabant, M, Legendre, C, Moestrup, S K, Levtchenko, E, Bultynck, G, Erneux, C, Pérez-Morga, D & Pays, E 2020, ' APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin ', Cell Reports, vol. 30, no. 11, pp. 3821-3836 . https://doi.org/10.1016/j.celrep.2020.02.064
Cell Reports
Uzureau, S, Lecordier, L, Uzureau, P, Hennig, D, Graversen, J H, Homblé, F, Mfutu, P E, Oliveira Arcolino, F, Ramos, A R, La Rovere, R M, Luyten, T, Vermeersch, M, Tebabi, P, Dieu, M, Cuypers, B, Deborggraeve, S, Rabant, M, Legendre, C, Moestrup, S K, Levtchenko, E, Bultynck, G, Erneux, C, Pérez-Morga, D & Pays, E 2020, ' APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin ', Cell Reports, vol. 30, no. 11, pp. 3821-3836.e13 . https://doi.org/10.1016/j.celrep.2020.02.064
Cell reports, 30 (11
Cell Reports, Vol 30, Iss 11, Pp 3821-3836.e13 (2020)
Cell reports

Summary The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb521d30392cbb871aac6dc615d4c993
https://findresearcher.sdu.dk:8443/ws/files/168815992/Open_Access_Version.pdf

Towards understanding of plant mitochondrial VDAC proteins: an overview of bean (Phaseolus) VDAC proteins

Autor: Daria Grobys, Hanna Kmita, Fabrice Homblé, Hayet Saidani, Marc Leonetti

Publikováno v: AIMS Biophysics. 4:43-62

As the main grain legume consumed worldwide, the common bean (Phaseolus vulgaris) is generally considered as a model for food legumes. The mitochondrial voltage-dependent anion-selective channel (VDAC) is the major transport pathway for inorganic ion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0a8a16f15bbe791710ae8dfe347ec0b
https://doi.org/10.3934/biophy.2017.1.43